MAP Kinase Kinase Kinase 1
"MAP Kinase Kinase Kinase 1" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A 195-kDa zinc finger motif-containing MAP kinase kinase kinase with broad specificity for MAP KINASE KINASES. It localizes to the CYTOSKELETON and can activate a variety of MAP kinase-dependent pathways.
| Descriptor ID |
D048728
|
| MeSH Number(s) |
D08.811.913.696.620.682.700.559.100 D12.644.360.400.100 D12.776.476.400.100
|
| Concept/Terms |
MAP Kinase Kinase Kinase 1- MAP Kinase Kinase Kinase 1
- MEKK1 Protein
- Mitogen-Activated Protein Kinase Kinase Kinase 1
- Mitogen Activated Protein Kinase Kinase Kinase 1
- MEKK-1 Protein Kinase
- MEKK 1 Protein Kinase
- Protein Kinase, MEKK-1
- MEK Kinase 1
- MEKK1 Protein Kinase
- MAP3K1 Protein
- MAP ERK Kinase Kinase 1
|
Below are MeSH descriptors whose meaning is more general than "MAP Kinase Kinase Kinase 1".
Below are MeSH descriptors whose meaning is more specific than "MAP Kinase Kinase Kinase 1".
This graph shows the total number of publications written about "MAP Kinase Kinase Kinase 1" by people in this website by year, and whether "MAP Kinase Kinase Kinase 1" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2000 | 1 | 0 | 1 |
| 2002 | 3 | 0 | 3 |
| 2007 | 0 | 1 | 1 |
| 2011 | 0 | 1 | 1 |
| 2012 | 0 | 1 | 1 |
| 2013 | 0 | 1 | 1 |
| 2018 | 1 | 2 | 3 |
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Below are the most recent publications written about "MAP Kinase Kinase Kinase 1" by people in Profiles.
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The prognostic effects of somatic mutations in ER-positive breast cancer. Nat Commun. 2018 09 04; 9(1):3476.
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The MAPK Kinase Kinase GmMEKK1 Regulates Cell Death and Defense Responses. Plant Physiol. 2018 10; 178(2):907-922.
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CD271+ Cells Are Diagnostic and Prognostic and Exhibit Elevated MAPK Activity in SHH Medulloblastoma. Cancer Res. 2018 08 15; 78(16):4745-4759.
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Differential regulation of c-Jun protein plays an instrumental role in chemoresistance of cancer cells. J Biol Chem. 2013 Jul 05; 288(27):19321-9.
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Comprehensive molecular portraits of human breast tumours. Nature. 2012 Oct 04; 490(7418):61-70.
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Whole-genome analysis informs breast cancer response to aromatase inhibition. Nature. 2012 Jun 10; 486(7403):353-60.
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Functional genomic screen and network analysis reveal novel modifiers of tauopathy dissociated from tau phosphorylation. Hum Mol Genet. 2011 Dec 15; 20(24):4947-77.
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Induction of COX-2 by acrolein in rat lung epithelial cells. Mol Cell Biochem. 2007 Jul; 301(1-2):191-9.
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MEKK1 mediates the ubiquitination and degradation of c-Jun in response to osmotic stress. Mol Cell Biol. 2007 Jan; 27(2):510-7.
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A role for the mitogen-activated protein kinase kinase kinase 1 in epithelial wound healing. Mol Biol Cell. 2006 Aug; 17(8):3446-55.