"Glutaredoxins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A family of thioltransferases that contain two active site CYSTEINE residues, which either form a disulfide (oxidized form) or a dithiol (reduced form). They function as an electron carrier in the GLUTHIONE-dependent synthesis of deoxyribonucleotides by RIBONUCLEOTIDE REDUCTASES and may play a role in the deglutathionylation of protein thiols. The oxidized forms of glutaredoxins are directly reduced by the GLUTATHIONE.
| Descriptor ID |
D054477
|
| MeSH Number(s) |
D08.811.682.667.084
|
| Concept/Terms |
Glutaredoxin 1- Glutaredoxin 1
- TTase-1
- TTase 1
- Thioltransferase-1
- Thioltransferase 1
|
Below are MeSH descriptors whose meaning is more general than "Glutaredoxins".
Below are MeSH descriptors whose meaning is more specific than "Glutaredoxins".
This graph shows the total number of publications written about "Glutaredoxins" by people in this website by year, and whether "Glutaredoxins" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2005 | 0 | 1 | 1 |
| 2011 | 1 | 0 | 1 |
| 2012 | 1 | 0 | 1 |
| 2013 | 1 | 0 | 1 |
| 2016 | 1 | 0 | 1 |
| 2017 | 1 | 0 | 1 |
| 2019 | 1 | 0 | 1 |
| 2020 | 1 | 0 | 1 |
| 2021 | 1 | 0 | 1 |
| 2023 | 1 | 1 | 2 |
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Below are the most recent publications written about "Glutaredoxins" by people in Profiles.
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Liver specific disruption of Glutaredoxin 3 leads to iron accumulation and impaired cellular iron homeostasis. Biochem Biophys Res Commun. 2023 03 15; 649:39-46.
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Crucial role of Arabidopsis glutaredoxin S17 in heat stress response revealed by transcriptome analysis. Funct Plant Biol. 2023 01; 50(1):58-70.
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Crucial Role of Mammalian Glutaredoxin 3 in Cardiac Energy Metabolism in Diet-induced Obese Mice Revealed by Transcriptome Analysis. Int J Biol Sci. 2021; 17(11):2871-2883.
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Alteration of iron responsive gene expression in Arabidopsis glutaredoxin S17 loss of function plants with or without iron stress. Plant Signal Behav. 2020 06 02; 15(6):1758455.
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Cardiac-specific ablation of glutaredoxin 3 leads to cardiac hypertrophy and heart failure. Physiol Rep. 2019 04; 7(8):e14071.
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PPARa-Target Gene Expression Requires TIS21/BTG2 Gene in Liver of the C57BL/6 Mice under Fasting Condition. Mol Cells. 2018 Feb 28; 41(2):140-149.
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Expression of a monothiol glutaredoxin, AtGRXS17, in tomato (Solanum lycopersicum) enhances drought tolerance. Biochem Biophys Res Commun. 2017 09 30; 491(4):1034-1039.
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Loss of glutaredoxin 3 impedes mammary lobuloalveolar development during pregnancy and lactation. Am J Physiol Endocrinol Metab. 2017 03 01; 312(3):E136-E149.
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Structural insights into the N-terminal GIY-YIG endonuclease activity of Arabidopsis glutaredoxin AtGRXS16 in chloroplasts. Proc Natl Acad Sci U S A. 2013 Jun 04; 110(23):9565-70.
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Ectopic expression of Arabidopsis glutaredoxin AtGRXS17 enhances thermotolerance in tomato. Plant Biotechnol J. 2012 Oct; 10(8):945-55.