MAP Kinase Kinase Kinase 2
"MAP Kinase Kinase Kinase 2" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A 70-kDa MAP kinase kinase kinase with specificity for MAP KINASE KINASE 5. It is activated during the cellular response to GROWTH FACTORS, oxidative stress, and hyperosmotic conditions.
| Descriptor ID |
D048730
|
| MeSH Number(s) |
D08.811.913.696.620.682.700.559.200 D12.644.360.400.200 D12.776.476.400.200
|
| Concept/Terms |
MAP Kinase Kinase Kinase 2- MAP Kinase Kinase Kinase 2
- MEKK-2 Protein Kinase
- MEKK 2 Protein Kinase
- Protein Kinase, MEKK-2
- MEKK2 Protein Kinase
- Protein Kinase, MEKK2
- MAP3K2 Protein Kinase
- Protein Kinase, MAP3K2
- MEKK2 Protein
- MEK Kinase 2
|
Below are MeSH descriptors whose meaning is more general than "MAP Kinase Kinase Kinase 2".
Below are MeSH descriptors whose meaning is more specific than "MAP Kinase Kinase Kinase 2".
This graph shows the total number of publications written about "MAP Kinase Kinase Kinase 2" by people in this website by year, and whether "MAP Kinase Kinase Kinase 2" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2002 | 0 | 1 | 1 |
| 2003 | 0 | 2 | 2 |
| 2014 | 1 | 0 | 1 |
| 2017 | 0 | 1 | 1 |
| 2021 | 1 | 0 | 1 |
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Below are the most recent publications written about "MAP Kinase Kinase Kinase 2" by people in Profiles.
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A mitochondrial contribution to anti-inflammatory shear stress signaling in vascular endothelial cells. J Cell Biol. 2022 07 04; 221(7).
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Mass-spectrometry-based proteomic correlates of grade and stage reveal pathways and kinases associated with aggressive human cancers. Oncogene. 2021 03; 40(11):2081-2095.
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Phase I trial of MEK 1/2 inhibitor pimasertib combined with mTOR inhibitor temsirolimus in patients with advanced solid tumors. Invest New Drugs. 2017 10; 35(5):616-626.
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Cancer signaling: when phosphorylation meets methylation. Cell Res. 2014 Nov; 24(11):1282-3.
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Identification of MEKK2/3 serine phosphorylation site targeted by the Toll-like receptor and stress pathways. EMBO J. 2006 Jan 11; 25(1):97-107.
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Mechanisms of proinflammatory cytokine-induced biphasic NF-kappaB activation. Mol Cell. 2003 Nov; 12(5):1287-300.
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Translation inhibitors sensitize prostate cancer cells to apoptosis induced by tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) by activating c-Jun N-terminal kinase. J Biol Chem. 2003 Jun 06; 278(23):20593-602.
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Disruption of Mekk2 in mice reveals an unexpected role for MEKK2 in modulating T-cell receptor signal transduction. Mol Cell Biol. 2002 Aug; 22(16):5761-8.
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MEKK2 is required for T-cell receptor signals in JNK activation and interleukin-2 gene expression. J Biol Chem. 2001 May 04; 276(18):14784-90.
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Synergistic interaction of MEK kinase 2, c-Jun N-terminal kinase (JNK) kinase 2, and JNK1 results in efficient and specific JNK1 activation. Mol Cell Biol. 2000 Apr; 20(7):2334-42.