MAP Kinase Kinase Kinase 3
"MAP Kinase Kinase Kinase 3" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A 70-kDa MAPK kinase kinase with specificity for MAP KINASE KINASE 5.
| Descriptor ID |
D048748
|
| MeSH Number(s) |
D08.811.913.696.620.682.700.559.300 D12.644.360.400.300 D12.776.476.400.300
|
| Concept/Terms |
MAP Kinase Kinase Kinase 3- MAP Kinase Kinase Kinase 3
- MAPK-ERK Kinase Kinase 3
- MAPK ERK Kinase Kinase 3
- MEK Kinase 3
- MEKK3 Protein Kinase
- Protein Kinase, MEKK3
- Mitogen-Activated Protein Kinase Kinase Kinase 3
- Mitogen Activated Protein Kinase Kinase Kinase 3
- MAP3K3 Protein Kinase
- Protein Kinase, MAP3K3
- ERK Kinase Kinase 3
|
Below are MeSH descriptors whose meaning is more general than "MAP Kinase Kinase Kinase 3".
Below are MeSH descriptors whose meaning is more specific than "MAP Kinase Kinase Kinase 3".
This graph shows the total number of publications written about "MAP Kinase Kinase Kinase 3" by people in this website by year, and whether "MAP Kinase Kinase Kinase 3" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2002 | 0 | 1 | 1 |
| 2003 | 0 | 3 | 3 |
| 2004 | 1 | 0 | 1 |
| 2005 | 1 | 0 | 1 |
| 2006 | 1 | 0 | 1 |
| 2009 | 2 | 0 | 2 |
| 2010 | 1 | 1 | 2 |
| 2013 | 0 | 1 | 1 |
| 2014 | 1 | 1 | 2 |
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Below are the most recent publications written about "MAP Kinase Kinase Kinase 3" by people in Profiles.
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A mitochondrial contribution to anti-inflammatory shear stress signaling in vascular endothelial cells. J Cell Biol. 2022 07 04; 221(7).
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Brominated flame retardants, tetrabromobisphenol A and hexabromocyclododecane, activate mitogen-activated protein kinases (MAPKs) in human natural killer cells. Cell Biol Toxicol. 2014 Dec; 30(6):345-60.
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Amplification and over-expression of MAP3K3 gene in human breast cancer promotes formation and survival of breast cancer cells. J Pathol. 2014 Jan; 232(1):75-86.
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IRAK-M mediates Toll-like receptor/IL-1R-induced NF?B activation and cytokine production. EMBO J. 2013 Feb 20; 32(4):583-96.
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Protein phosphatase 2A acts as a mitogen-activated protein kinase kinase kinase 3 (MEKK3) phosphatase to inhibit lysophosphatidic acid-induced IkappaB kinase beta/nuclear factor-kappaB activation. J Biol Chem. 2010 Jul 09; 285(28):21341-8.
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Vasculogenesis driven by bone marrow-derived cells is essential for growth of Ewing's sarcomas. Cancer Res. 2010 Feb 15; 70(4):1334-43.
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Phosphorylation of Thr-516 and Ser-520 in the kinase activation loop of MEKK3 is required for lysophosphatidic acid-mediated optimal IkappaB kinase beta (IKKbeta)/nuclear factor-kappaB (NF-kappaB) activation. J Biol Chem. 2010 Mar 12; 285(11):7911-8.
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MEKK3 expression correlates with nuclear factor kappa B activity and with expression of antiapoptotic genes in serous ovarian carcinoma. Cancer. 2009 Sep 01; 115(17):3897-908.
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MEKK3 is required for lysophosphatidic acid-induced NF-kappaB activation. Cell Signal. 2009 Oct; 21(10):1488-94.
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MEKK3 is required for endothelium function but is not essential for tumor growth and angiogenesis. Am J Physiol Cell Physiol. 2007 Oct; 293(4):C1404-11.