Low Density Lipoprotein Receptor-Related Protein-2
"Low Density Lipoprotein Receptor-Related Protein-2" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An LDL-RECEPTOR RELATED PROTEIN found in the neuroepithelium and in proximal tubular cells of the kidney. It is considered a multiligand receptor in that it binds to a variety of ligands with relatively high affinity and may function in mediating the uptake and lysosomal degradation of macromolecules such as: LIPOPROTEINS; ENDOPEPTIDASES; and PROTEASE INHIBITORS.
| Descriptor ID |
D026561
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| MeSH Number(s) |
D12.776.526.200 D12.776.543.750.710.450.500.200 D23.050.422.500.500
|
| Concept/Terms |
Low Density Lipoprotein Receptor-Related Protein-2- Low Density Lipoprotein Receptor-Related Protein-2
- Low Density Lipoprotein Receptor Related Protein 2
- LDL-Receptor Related Protein 2
- LDL Receptor Related Protein 2
- Low-Density Lipoprotein Receptor-Related Protein-2
- LRP-2 Receptor
- LRP 2 Receptor
- Megalin
- Heyman's Nephritis Antigen GP330
- Renal Glycoprotein GP330
- GP330, Renal Glycoprotein
- Glycoprotein GP330, Renal
- Antigen GP 330, Nephritis
- Glycoprotein 330
- GP330 Antigen
- Heymann Nephritis Antigen GP330
- Nephritis Antigen (GP330)
|
Below are MeSH descriptors whose meaning is more general than "Low Density Lipoprotein Receptor-Related Protein-2".
Below are MeSH descriptors whose meaning is more specific than "Low Density Lipoprotein Receptor-Related Protein-2".
This graph shows the total number of publications written about "Low Density Lipoprotein Receptor-Related Protein-2" by people in this website by year, and whether "Low Density Lipoprotein Receptor-Related Protein-2" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2008 | 1 | 0 | 1 |
| 2012 | 0 | 1 | 1 |
| 2014 | 3 | 0 | 3 |
| 2018 | 1 | 0 | 1 |
| 2022 | 1 | 0 | 1 |
| 2023 | 1 | 0 | 1 |
| 2024 | 0 | 1 | 1 |
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Below are the most recent publications written about "Low Density Lipoprotein Receptor-Related Protein-2" by people in Profiles.
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Mechanisms of gelofusine protection in an in vitro model of polymyxin B-associated renal injury. Am J Physiol Renal Physiol. 2024 Jul 01; 327(1):F137-F145.
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Angiotensin II type 2 receptor activation preserves megalin in the kidney and prevents proteinuria in high salt diet fed rats. Sci Rep. 2023 03 15; 13(1):4277.
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Interactions between leucines within the signal peptides of megalin and stanniocalcin-1 are crucial for regulation of mitochondrial metabolism. Lab Invest. 2022 05; 102(5):534-544.
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Megalin mediates plasma membrane to mitochondria cross-talk and regulates mitochondrial metabolism. Cell Mol Life Sci. 2018 Nov; 75(21):4021-4040.
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Reply to "measuring polymyxin uptake by renal tubular cells: is BODIPY-polymyxin B an appropriate probe?". Antimicrob Agents Chemother. 2014 Oct; 58(10):6339.
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Uptake of polymyxin B into renal cells. Antimicrob Agents Chemother. 2014 Jul; 58(7):4200-2.
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LRP2 mediates folate uptake in the developing neural tube. J Cell Sci. 2014 May 15; 127(Pt 10):2261-8.
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Broadening the phenotype of LRP2 mutations: a new mutation in LRP2 causes a predominantly ocular phenotype suggestive of Stickler syndrome. Clin Genet. 2014 Sep; 86(3):282-6.
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Integration of genome-wide association studies with biological knowledge identifies six novel genes related to kidney function. Hum Mol Genet. 2012 Dec 15; 21(24):5329-43.
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Microarray analysis of E9.5 reduced folate carrier (RFC1; Slc19a1) knockout embryos reveals altered expression of genes in the cubilin-megalin multiligand endocytic receptor complex. BMC Genomics. 2008 Apr 09; 9:156.