"Aspartate-Ammonia Ligase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An enzyme that catalyzes the formation of asparagine from ammonia and aspartic acid, in the presence of ATP. EC 6.3.1.1.
| Descriptor ID |
D001217
|
| MeSH Number(s) |
D08.811.464.259.200.200
|
| Concept/Terms |
Aspartate-Ammonia Ligase- Aspartate-Ammonia Ligase
- Aspartate Ammonia Ligase
- Ligase, Aspartate-Ammonia
- Asparagine Synthase
- Synthase, Asparagine
- Asparagine Synthetase
- Synthetase, Asparagine
|
Below are MeSH descriptors whose meaning is more general than "Aspartate-Ammonia Ligase".
Below are MeSH descriptors whose meaning is more specific than "Aspartate-Ammonia Ligase".
This graph shows the total number of publications written about "Aspartate-Ammonia Ligase" by people in this website by year, and whether "Aspartate-Ammonia Ligase" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2006 | 1 | 0 | 1 |
| 2007 | 0 | 1 | 1 |
| 2008 | 1 | 0 | 1 |
| 2009 | 1 | 0 | 1 |
| 2012 | 1 | 0 | 1 |
| 2013 | 1 | 0 | 1 |
| 2014 | 1 | 0 | 1 |
| 2019 | 1 | 0 | 1 |
| 2021 | 1 | 1 | 2 |
| 2024 | 2 | 1 | 3 |
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Below are the most recent publications written about "Aspartate-Ammonia Ligase" by people in Profiles.
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CASPER: A Phase I trial combining calaspargase pegol-mnkl and cobimetinib in pancreatic cancer. Future Oncol. 2024; 20(37):2915-2925.
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Reverse Phase Proteomic Array Profiling of Asparagine Synthetase Expression in Newly Diagnosed Acute Myeloid Leukemia. J Proteome Res. 2024 Jul 05; 23(7):2495-2504.
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Asparagine Synthetase Marks a Distinct Dependency Threshold for Cardiomyocyte Dedifferentiation. Circulation. 2024 Jun 04; 149(23):1833-1851.
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Compound NSC84167 selectively targets NRF2-activated pancreatic cancer by inhibiting asparagine synthesis pathway. Cell Death Dis. 2021 07 10; 12(7):693.
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Prohibitin 1 is essential to preserve mitochondria and myelin integrity in Schwann cells. Nat Commun. 2021 06 02; 12(1):3285.
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Glutaminase Activity of L-Asparaginase Contributes to Durable Preclinical Activity against Acute Lymphoblastic Leukemia. Mol Cancer Ther. 2019 09; 18(9):1587-1592.
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The glutaminase activity of L-asparaginase is not required for anticancer activity against ASNS-negative cells. Blood. 2014 Jun 05; 123(23):3596-606.
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An extracellular bacterial pathogen modulates host metabolism to regulate its own sensing and proliferation. Cell. 2014 Jan 16; 156(1-2):97-108.
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Red blood cell-encapsulated L-asparaginase: potential therapy of patients with asparagine synthetase deficient acute myeloid leukemia. Protein Pept Lett. 2013 Apr; 20(4):392-402.
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Integrative molecular profiling reveals asparagine synthetase is a target in castration-resistant prostate cancer. Am J Pathol. 2012 Mar; 180(3):895-903.