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ROBERT CABRERA

TitleAssociate Professor
InstitutionBaylor College of Medicine
DepartmentDepartment of Molecular & Cellular Biology
Address6501 Fannin St
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    Other Positions
    TitleAssociate Professor
    InstitutionBaylor College of Medicine
    DepartmentCenter for Precision Environmental Health
    DivisionCenter for Precision Env Health


    Collapse Research 
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    R21MH122252     (CABRERA, ROBERT M)Sep 24, 2019 - Jul 31, 2021
    NIH/NIMH
    Pathogenic Linking of HIV Integrase Inhibitors, Folate Receptors, and Cerebral Folate Deficiency
    Role: Principal Investigator
    R01HD100229     (CABRERA, ROBERT M)Sep 18, 2019 - Jul 31, 2024
    NIH
    Plausible Causative Mechanism for Dolutegravir Developmental Toxicity
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Maier SE, Cabrera RM, Chen Y, Vargesson N, Maier SE, Cabrera RM, Chen Y. Emerging and novel technologies in reproductive and developmental toxicology. Reprod Toxicol. 2024 Dec; 130:108705. PMID: 39222888.
      Citations:    Fields:    
    2. Caiaffa CD, Tukeman G, Delgado CZ, Ambekar YS, Mekonnen TT, Singh M, Rodriguez V, Ricco E, Kraushaar D, Aglyamov SR, Scarcelli G, Larin KV, Finnell RH, Cabrera RM. Dolutegravir induces FOLR1 expression during brain organoid development. Front Mol Neurosci. 2024; 17:1394058. PMID: 38828282; PMCID: PMC11140035.
      Citations: 2     
    3. Tukeman GL, Wei H, Lin YL, Wlodarczyk BJ, Finnell RH, Cabrera RM. Dolutegravir-induced neural tube defects in mice are folate responsive. AIDS. 2024 03 15; 38(4):439-446. PMID: 37382903; PMCID: PMC10755062.
      Citations: 1     Fields:    Translation:HumansAnimals
    4. Han X, Cao X, Cabrera RM, Ramirez PAP, Lin YL, Wlodarczyk BJ, Zhang C, Finnell RH, Lei Y. Folate regulation of planar cell polarity pathway and F-actin through folate receptor alpha. FASEB J. 2024 01; 38(1):e23346. PMID: 38095297; PMCID: PMC10754249.
      Citations: 1     Fields:    Translation:AnimalsCells
    5. Cao X, Xu J, Lin YL, Cabrera RM, Chen Q, Zhang C, Steele JW, Han X, Gross SS, Wlodarczyk BJ, Lupski JR, Li W, Wang H, Finnell RH, Lei Y. Excess folic acid intake increases DNA de novo point mutations. Cell Discov. 2023 Feb 28; 9(1):22. PMID: 36849450; PMCID: PMC9970956.
      Citations: 4     
    6. Han X, Cao X, Cabrera RM, Pimienta Ramirez PA, Zhang C, Ramaekers VT, Finnell RH, Lei Y. KDM6B Variants May Contribute to the Pathophysiology of Human Cerebral Folate Deficiency. Biology (Basel). 2022 Dec 31; 12(1). PMID: 36671766; PMCID: PMC9855468.
      Citations: 3     
    7. Han X, Cao X, Aguiar-Pulido V, Yang W, Karki M, Ramirez PAP, Cabrera RM, Lin YL, Wlodarczyk BJ, Shaw GM, Ross ME, Zhang C, Finnell RH, Lei Y. CIC missense variants contribute to susceptibility for spina bifida. Hum Mutat. 2022 12; 43(12):2021-2032. PMID: 36054333; PMCID: PMC9772115.
      Citations:    
    8. Palacios AM, Feiner RA, Cabrera RM. Characterization of folic acid, 5-methyltetrahydrofolate and synthetic folinic acid in the high-affinity folate transporters: impact on pregnancy and development. Reprod Dev Med. 2023 Jun; 7(2):102-107. PMID: 37313449; PMCID: PMC10259187.
      Citations:    
    9. Steele JW, Lin YL, Chen N, Wlodarczyk BJ, Chen Q, Attarwala N, Venkatesalu M, Cabrera RM, Gross SS, Finnell RH. Embryonic Hypotaurine Levels Contribute to Strain-Dependent Susceptibility in Mouse Models of Valproate-Induced Neural Tube Defects. Front Cell Dev Biol. 2022; 10:832492. PMID: 35265619; PMCID: PMC8898900.
      Citations:    
    10. Finnell RH, Caiaffa CD, Kim SE, Lei Y, Steele J, Cao X, Tukeman G, Lin YL, Cabrera RM, Wlodarczyk BJ. Gene Environment Interactions in the Etiology of Neural Tube Defects. Front Genet. 2021; 12:659612. PMID: 34040637; PMCID: PMC8143787.
      Citations: 5     
    11. Tian T, Lai X, Xiang K, Han X, Yin S, Cabrera RM, Steele JW, Lei Y, Cao X, Finnell RH, Wang L, Ren A. Hypermethylation of PI3K-AKT signalling pathway genes is associated with human neural tube defects. Epigenetics. 2022 Jan-Feb; 17(2):133-146. PMID: 33491544; PMCID: PMC8865305.
      Citations:    Fields:    Translation:HumansCells
    12. Tian T, Cao X, Kim SE, Lin YL, Steele JW, Cabrera RM, Karki M, Yang W, Marini NJ, Hoffman EN, Han X, Hu C, Wang L, Wlodarczyk BJ, Shaw GM, Ren A, Finnell RH, Lei Y. FKBP8 variants are risk factors for spina bifida. Hum Mol Genet. 2020 11 04; 29(18):3132-3144. PMID: 32969478; PMCID: PMC7645715.
      Citations: 3     Fields:    Translation:HumansAnimals
    13. Cao X, Kim SE, Cabrera RM, Wlodarczyk BJ, Zhu H, Parker M, Lin Y, Steele JW, Han X, Finnell RH, Lei Y, Wolf A, Ramaekers VT, Steinfeld R. CIC de novo loss of function variants contribute to cerebral folate deficiency by downregulating FOLR1 expression. J Med Genet. 2021 07; 58(7):484-494. PMID: 32820034; PMCID: PMC7895856.
      Citations: 3     Fields:    Translation:HumansCells
    14. Taiwo TE, Cao X, Cabrera RM, Lei Y, Finnell RH. Approaches to studying the genomic architecture of complex birth defects. Prenat Diagn. 2020 08; 40(9):1047-1055. PMID: 32468575; PMCID: PMC8117178.
      Citations: 2     Fields:    Translation:HumansAnimals
    15. Cabrera RM, Linda Lin Y, Law E, Kim J, Wlodarczyk BJ. The teratogenic effects of sertraline in mice. Birth Defects Res. 2020 08; 112(13):1014-1024. PMID: 32077266.
      Citations: 2     Fields:    Translation:HumansAnimals
    16. Cao X, Tian T, Steele JW, Cabrera RM, Aguiar-Pulido V, Wadhwa S, Bhavani N, Bi P, Gargurevich NH, Hoffman EN, Cai CQ, Marini NJ, Yang W, Shaw GM, Ross ME, Finnell RH, Lei Y. Loss of RAD9B impairs early neural development and contributes to the risk for human spina bifida. Hum Mutat. 2020 04; 41(4):786-799. PMID: 31898828; PMCID: PMC7185173.
      Citations: 8     Fields:    Translation:HumansCells
    17. Katz TA, Grimm SL, Kaushal A, Dong J, Jangid RK, Bertocchio JP, Guan Y, Robertson MJ, Cabrera RM, Finegold MJ, Foulds CE, Coarfa C, Walker CL, Trevi?o LS, Gait?n AV. Hepatic Tumor Formation in Adult Mice Developmentally Exposed to Organotin. Environ Health Perspect. 2020 01; 128(1):17010. PMID: 31939706; PMCID: PMC7015627.
      Citations: 2     Fields:    Translation:HumansAnimals
    18. Cabrera RM, Souder JP, Steele JW, Yeo L, Tukeman G, Gorelick DA, Finnell RH. The antagonism of folate receptor by dolutegravir: developmental toxicity reduction by supplemental folic acid. AIDS. 2019 11 01; 33(13):1967-1976. PMID: 31259764; PMCID: PMC6774845.
      Citations: 7     Fields:    Translation:HumansAnimalsCells
    19. Steele JW, Bayliss S, Bayliss J, Lin YL, Wlodarczyk BJ, Cabrera RM, Asfaw YG, Cummings TJ, Finnell RH, George TM. Heritable spina bifida in sheep: A potential model for fetal repair of myelomeningocele. J Pediatr Surg. 2020 Mar; 55(3):475-481. PMID: 31301886; PMCID: PMC6935438.
      Citations: 4     Fields:    Translation:Animals
    20. Lin YL, Bialer M, Cabrera RM, Finnell RH, Wlodarczyk BJ. Teratogenicity of valproic acid and its constitutional isomer, amide derivative valnoctamide in mice. Birth Defects Res. 2019 08 15; 111(14):1013-1023. PMID: 30325584.
      Citations: 5     Fields:    Translation:Animals
    21. Conde-Vancells J, Vazquez-Chantada M, McCollum CW, Bondesson M, Kalasekar SM, Wlodarczyk BJ, Cabrera RM, Finnell RH, Gustafsson J?. Combining mouse embryonic stem cells and zebrafish embryos to evaluate developmental toxicity of chemical exposure. Reprod Toxicol. 2018 10; 81:220-228. PMID: 30103011.
      Citations:    Fields:    Translation:AnimalsCells
    22. Dong Y, Wang L, Lei Y, Yang N, Cabrera RM, Finnell RH, Ren A. Gene variants in the folate pathway are associated with increased levels of folate receptor autoantibodies. Birth Defects Res. 2018 07 17; 110(12):973-981. PMID: 29732742; PMCID: PMC6276117.
      Citations: 4     Fields:    Translation:Humans
    23. Kim J, Lei Y, Guo J, Kim SE, Wlodarczyk BJ, Cabrera RM, Lin YL, Nilsson TK, Zhang T, Ren A, Wang L, Yuan Z, Zheng YF, Wang HY, Finnell RH. Formate rescues neural tube defects caused by mutations in Slc25a32. Proc Natl Acad Sci U S A. 2018 05 01; 115(18):4690-4695. PMID: 29666258; PMCID: PMC5939102.
      Citations: 17     Fields:    Translation:HumansAnimals
    24. Vichier-Guerre C, Parker M, Pomerantz Y, Finnell RH, Cabrera RM. Impact of selective serotonin reuptake inhibitors on neural crest stem cell formation. Toxicol Lett. 2017 Nov 05; 281:20-25. PMID: 28844482.
      Citations: 7     Fields:    Translation:HumansCells
    25. Yang N, Wang L, Finnell RH, Li Z, Jin L, Zhang L, Cabrera RM, Ye R, Ren A. Corrigendum for: Levels of folate receptor autoantibodies in maternal and cord blood and risk of neural tube defects in a Chinese population, 106:685-695 (10.1002/bdra.23517). Birth Defects Res A Clin Mol Teratol. 2016 12; 106(12):1062. PMID: 28000437.
      Citations:    Fields:    
    26. Wilkerson JL, Ghosh S, Mustafa M, Abdullah RA, Niphakis MJ, Cabrera R, Maldonado RL, Cravatt BF, Lichtman AH. The endocannabinoid hydrolysis inhibitor SA-57: Intrinsic antinociceptive effects, augmented morphine-induced antinociception, and attenuated heroin seeking behavior in mice. Neuropharmacology. 2017 03 01; 114:156-167. PMID: 27890602; PMCID: PMC5289715.
      Citations: 32     Fields:    Translation:AnimalsCells
    27. McCollum CW, Conde-Vancells J, Hans C, Vazquez-Chantada M, Kleinstreuer N, Tal T, Knudsen T, Shah SS, Merchant FA, Finnell RH, Cabrera R, Bondesson M, Gustafsson J?. Identification of vascular disruptor compounds by analysis in zebrafish embryos and mouse embryonic endothelial cells. Reprod Toxicol. 2017 06; 70:60-69. PMID: 27838387; PMCID: PMC5425326.
      Citations: 8     Fields:    Translation:AnimalsCells
    28. Yang N, Wang L, Finnell RH, Li Z, Jin L, Zhang L, Cabrera RM, Ye R, Ren A. Levels of folate receptor autoantibodies in maternal and cord blood and risk of neural tube defects in a Chinese population. Birth Defects Res A Clin Mol Teratol. 2016 Aug; 106(8):685-95. PMID: 27166990; PMCID: PMC4983204.
      Citations: 7     Fields:    Translation:Humans
    29. Denny KJ, Kelly CF, Kumar V, Witham KL, Cabrera RM, Finnell RH, Taylor SM, Jeanes A, Woodruff TM. Autoantibodies against homocysteinylated protein in a mouse model of folate deficiency-induced neural tube defects. Birth Defects Res A Clin Mol Teratol. 2016 Mar; 106(3):201-7. PMID: 26900104; PMCID: PMC4801756.
      Citations: 7     Fields:    Translation:HumansAnimalsCells
    30. Cabrera R, Maldonado R, Rodr?guez-Arias M, Montagud-Romero S, Rubio-Araiz A, Aguilar MA, Mart?n-Garc?a E, Porcu F, Colado MI, Mi?arro J. Effects of repeated social defeat on adolescent mice on cocaine-induced CPP and self-administration in adulthood: integrity of the blood-brain barrier. Addict Biol. 2017 Jan; 22(1):129-141. PMID: 26374627.
      Citations: 25     Fields:    Translation:Animals
    31. Cabrera RM, Kur E, Mecklenburg N, Willnow TE, Hammes A. LRP2 mediates folate uptake in the developing neural tube. J Cell Sci. 2014 May 15; 127(Pt 10):2261-8. PMID: 24639464.
      Citations: 19     Fields:    Translation:Animals
    32. Gulvady AA, Ciolino HP, Cabrera RM, Jolly CA. Resveratrol inhibits the deleterious effects of diet-induced obesity on thymic function. J Nutr Biochem. 2013 Sep; 24(9):1625-33. PMID: 23561698.
      Citations: 6     Fields:    Translation:AnimalsCells
    33. Lai SC, Nakayama Y, Sequeira JM, Wlodarczyk BJ, Cabrera RM, Finnell RH, Bottiglieri T, Quadros EV. The transcobalamin receptor knockout mouse: a model for vitamin B12 deficiency in the central nervous system. FASEB J. 2013 Jun; 27(6):2468-75. PMID: 23430977; PMCID: PMC3659357.
      Citations: 14     Fields:    Translation:HumansAnimals
    34. Wang X, Cabrera RM, Li Y, Miller DS, Finnell RH. Functional regulation of P-glycoprotein at the blood-brain barrier in proton-coupled folate transporter (PCFT) mutant mice. FASEB J. 2013 Mar; 27(3):1167-75. PMID: 23212123; PMCID: PMC3574287.
      Citations: 10     Fields:    Translation:AnimalsCells
    35. Gulvady AA, Murphy EJ, Ciolino HP, Cabrera RM, Jolly CA. Glycerol-3-phosphate acyltransferase-1 gene ablation results in altered thymocyte lipid content and reduces thymic T cell production in mice. Lipids. 2013 Jan; 48(1):3-12. PMID: 23179391.
      Citations: 5     Fields:    Translation:HumansAnimalsCells
    36. Cabrera RM, Finnell RH, Zhu H, Shaw GM, Wlodarczyk BJ. Transcriptional analyses of two mouse models of spina bifida. Birth Defects Res A Clin Mol Teratol. 2012 Oct; 94(10):782-9. PMID: 23024056; PMCID: PMC3505988.
      Citations:    Fields:    Translation:HumansAnimalsCells
    37. Gallego X, Molas S, Amador-Arjona A, Marks MJ, Murtra P, Cabrera R, Maldonado R, Estivill X, Dierssen M, Robles N, Armengol L, Fern?ndez-Montes RD, Gratac?s M, Pumarola M, Sabri? J. Overexpression of the CHRNA5/A3/B4 genomic cluster in mice increases the sensitivity to nicotine and modifies its reinforcing effects. Amino Acids. 2012 Aug; 43(2):897-909. PMID: 22101982.
      Citations: 21     Fields:    Translation:HumansAnimalsCells
    38. Boyles AL, Ballard JL, Gorman EB, McConnaughey DR, Cabrera RM, Wilcox AJ, Lie RT, Finnell RH. Association between inhibited binding of folic acid to folate receptor alpha in maternal serum and folate-related birth defects in Norway. Hum Reprod. 2011 Aug; 26(8):2232-8. PMID: 21576080; PMCID: PMC3137385.
      Citations: 13     Fields:    Translation:Humans
    39. Salojin KV, Cabrera RM, Sun W, Chang WC, Lin C, Duncan L, Platt KA, Read R, Vogel P, Liu Q, Finnell RH, Oravecz T. A mouse model of hereditary folate malabsorption: deletion of the PCFT gene leads to systemic folate deficiency. Blood. 2011 May 05; 117(18):4895-904. PMID: 21346251.
      Citations: 29     Fields:    Translation:HumansAnimalsCells
    40. Bille C, Pedersen DA, Andersen AM, Mansilla MA, Murray JC, Christensen K, Ballard JL, Gorman EB, Cabrera RM, Finnell RH. Autoantibodies to folate receptor alpha during early pregnancy and risk of oral clefts in Denmark. Pediatr Res. 2010 Mar; 67(3):274-9. PMID: 19952865; PMCID: PMC2909840.
      Citations: 8     Fields:    Translation:Humans
    41. Jakubowski H, Finnell RH, Cabrera RM, Wang H, Gupta S, Kruger WD, Kraus JP, Shih DM, Perla-Kaj?n J. Genetic or nutritional disorders in homocysteine or folate metabolism increase protein N-homocysteinylation in mice. FASEB J. 2009 Jun; 23(6):1721-7. PMID: 19204075; PMCID: PMC3221610.
      Citations: 33     Fields:    Translation:HumansAnimals
    42. Cabrera RM, Shaw GM, Ballard JL, Carmichael SL, Yang W, Lammer EJ, Finnell RH. Autoantibodies to folate receptor during pregnancy and neural tube defect risk. J Reprod Immunol. 2008 Oct; 79(1):85-92. PMID: 18804286; PMCID: PMC3998370.
      Citations: 23     Fields:    Translation:Humans
    43. Zhu H, Cabrera RM, Wlodarczyk BJ, Bozinov D, Wang D, Schwartz RJ, Finnell RH. Differentially expressed genes in embryonic cardiac tissues of mice lacking Folr1 gene activity. BMC Dev Biol. 2007 Nov 20; 7:128. PMID: 18028541; PMCID: PMC2206038.
      Citations: 17     Fields:    Translation:Animals
    44. Wlodarczyk BJ, Cabrera RM, Hill DS, Bozinov D, Zhu H, Finnell RH. Arsenic-induced gene expression changes in the neural tube of folate transport defective mouse embryos. Neurotoxicology. 2006 Jul; 27(4):547-57. PMID: 16620997.
      Citations: 12     Fields:    Translation:Animals
    45. Massa V, Cabrera RM, Menegola E, Giavini E, Finnell RH. Valproic acid-induced skeletal malformations: associated gene expression cascades. Pharmacogenet Genomics. 2005 Nov; 15(11):787-800. PMID: 16220111.
      Citations: 12     Fields:    Translation:HumansAnimals
    46. Cabrera RM, Hill DS, Etheredge AJ, Finnell RH. Investigations into the etiology of neural tube defects. Birth Defects Res C Embryo Today. 2004 Dec; 72(4):330-44. PMID: 15662706.
      Citations: 18     Fields:    Translation:Humans
    47. Spiegelstein O, Cabrera RM, Bozinov D, Wlodarczyk B, Finnell RH. Folate-regulated changes in gene expression in the anterior neural tube of folate binding protein-1 (Folbp1)-deficient murine embryos. Neurochem Res. 2004 Jun; 29(6):1105-12. PMID: 15176467.
      Citations: 8     Fields:    Translation:AnimalsCells
    48. Lundberg YW, Cabrera RM, Greer KA, Zhao J, Garg R, Finnell RH. Mapping a chromosomal locus for valproic acid-induced exencephaly in mice. Mamm Genome. 2004 May; 15(5):361-9. PMID: 15170225.
      Citations: 7     Fields:    Translation:AnimalsPHPublic Health
    49. Finnell RH, Junker WM, Wadman LK, Cabrera RM. Gene expression profiling within the developing neural tube. Neurochem Res. 2002 Oct; 27(10):1165-80. PMID: 12462415.
      Citations: 4     Fields:    Translation:Animals
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