Low Density Lipoprotein Receptor-Related Protein-5
"Low Density Lipoprotein Receptor-Related Protein-5" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
LDL-receptor related protein that combines with FRIZZLED RECEPTORS at the cell surface to form receptors that bind WNT PROTEINS. The protein plays an important role in the WNT SIGNALING PATHWAY in OSTEOBLASTS and during EMBRYONIC DEVELOPMENT.
| Descriptor ID |
D060492
|
| MeSH Number(s) |
D12.776.526.500 D12.776.543.750.710.450.500.400 D12.776.543.750.850.687
|
| Concept/Terms |
Low Density Lipoprotein Receptor-Related Protein-5- Low Density Lipoprotein Receptor-Related Protein-5
- Low Density Lipoprotein Receptor Related Protein 5
- Low Density Lipoprotein Receptor-Related Protein 5
- Lipoprotein Receptor-Related Protein 5
- Lipoprotein Receptor Related Protein 5
|
Below are MeSH descriptors whose meaning is more general than "Low Density Lipoprotein Receptor-Related Protein-5".
Below are MeSH descriptors whose meaning is more specific than "Low Density Lipoprotein Receptor-Related Protein-5".
This graph shows the total number of publications written about "Low Density Lipoprotein Receptor-Related Protein-5" by people in this website by year, and whether "Low Density Lipoprotein Receptor-Related Protein-5" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2004 | 0 | 1 | 1 |
| 2006 | 0 | 1 | 1 |
| 2007 | 0 | 1 | 1 |
| 2010 | 0 | 1 | 1 |
| 2012 | 1 | 1 | 2 |
| 2015 | 0 | 1 | 1 |
| 2020 | 1 | 0 | 1 |
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Below are the most recent publications written about "Low Density Lipoprotein Receptor-Related Protein-5" by people in Profiles.
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Suppression of Membranous LRP5 Recycling, Wnt/?-Catenin Signaling, and Colon Carcinogenesis by 15-LOX-1 Peroxidation of Linoleic Acid in PI3P. Cell Rep. 2020 08 18; 32(7):108049.
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JAM3 maintains leukemia-initiating cell self-renewal through LRP5/AKT/?-catenin/CCND1 signaling. J Clin Invest. 2018 05 01; 128(5):1737-1751.
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Stearoyl-CoA Desaturase Promotes Liver Fibrosis and Tumor Development in Mice via a Wnt Positive-Signaling Loop by Stabilization of Low-Density Lipoprotein-Receptor-Related Proteins 5 and 6. Gastroenterology. 2017 05; 152(6):1477-1491.
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Next-generation sequencing and novel variant determination in a cohort of 92 familial exudative vitreoretinopathy patients. Invest Ophthalmol Vis Sci. 2015 Feb 24; 56(3):1937-46.
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FOXO1 orchestrates the bone-suppressing function of gut-derived serotonin. J Clin Invest. 2012 Oct; 122(10):3490-503.
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Activation of Wnt signaling by chemically induced dimerization of LRP5 disrupts cellular homeostasis. PLoS One. 2012; 7(1):e30814.
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Wnt and mammary stem cells: hormones cannot fly wingless. Curr Opin Pharmacol. 2010 Dec; 10(6):643-9.
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Low-density lipoprotein receptor-related protein 5 (LRP5) mediates the prostate cancer-induced formation of new bone. Oncogene. 2008 Jan 24; 27(5):596-603.
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The Wnt signaling receptor Lrp5 is required for mammary ductal stem cell activity and Wnt1-induced tumorigenesis. J Biol Chem. 2006 Nov 17; 281(46):35081-7.
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The ins and outs of Wingless signaling. Trends Cell Biol. 2004 Jan; 14(1):45-53.