"c-Mer Tyrosine Kinase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A receptor tyrosine kinase that transduces signals from EXTRACELLULAR MATRIX to the CYTOPLASM by binding ligands such as GALECTIN 3. It regulates many physiologic processes that include cell survival, migration, differentiation, and PHAGOCYTOSIS of apoptotic cells and ROD PHOTORECEPTORS in the RETINAL PIGMENT EPITHELIUM. Mutations in the MERTK gene are associated with type 38 RETINITIS PIGMENTOSA; it also plays a critical role as an inhibitor of TOLL-LIKE RECEPTORS signaling.
| Descriptor ID |
D000076202
|
| MeSH Number(s) |
D08.811.913.696.620.682.725.400.003 D12.776.543.750.630.003 D12.776.624.664.700.037
|
| Concept/Terms |
c-Mer Tyrosine Kinase- c-Mer Tyrosine Kinase
- Kinase, c-Mer Tyrosine
- Tyrosine Kinase, c-Mer
- c Mer Tyrosine Kinase
- c-Mer Proto-Oncogene Tyrosine Kinase
- c Mer Proto Oncogene Tyrosine Kinase
- MERTK
|
Below are MeSH descriptors whose meaning is more general than "c-Mer Tyrosine Kinase".
Below are MeSH descriptors whose meaning is more specific than "c-Mer Tyrosine Kinase".
This graph shows the total number of publications written about "c-Mer Tyrosine Kinase" by people in this website by year, and whether "c-Mer Tyrosine Kinase" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2008 | 0 | 2 | 2 |
| 2015 | 0 | 1 | 1 |
| 2017 | 0 | 1 | 1 |
| 2018 | 1 | 0 | 1 |
| 2019 | 1 | 0 | 1 |
| 2020 | 0 | 2 | 2 |
| 2022 | 1 | 0 | 1 |
| 2024 | 0 | 2 | 2 |
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Below are the most recent publications written about "c-Mer Tyrosine Kinase" by people in Profiles.
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Inhibition of MER proto-oncogene tyrosine kinase by an antisense oligonucleotide enhances treatment efficacy of immunoradiotherapy. J Exp Clin Cancer Res. 2024 Mar 06; 43(1):70.
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CADHERIN-11 regulation of myeloid phagocytes and autoimmune inflammation in murine lupus. J Autoimmun. 2024 05; 145:103197.
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AXL/MERTK inhibitor ONO-7475 potently synergizes with venetoclax and overcomes venetoclax resistance to kill FLT3-ITD acute myeloid leukemia. Haematologica. 2022 06 01; 107(6):1311-1322.
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TAM kinase inhibition and immune checkpoint blockade- a winning combination in cancer treatment? Expert Opin Ther Targets. 2021 02; 25(2):141-151.
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Microglia Actively Remodel Adult Hippocampal Neurogenesis through the Phagocytosis Secretome. J Neurosci. 2020 02 12; 40(7):1453-1482.
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Triple Therapy with MerTK and PD1 Inhibition Plus Radiotherapy Promotes Abscopal Antitumor Immune Responses. Clin Cancer Res. 2019 12 15; 25(24):7576-7584.
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The Cardiac Microenvironment Instructs Divergent Monocyte Fates and Functions in Myocarditis. Cell Rep. 2019 07 02; 28(1):172-189.e7.
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MerTK as a therapeutic target in glioblastoma. Neuro Oncol. 2018 01 10; 20(1):92-102.
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TAM Receptors Are Not Required for Zika Virus Infection in Mice. Cell Rep. 2017 04 18; 19(3):558-568.
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Monocyte and plasma expression of TAM ligand and receptor in renal failure: Links to unregulated immunity and chronic inflammation. Clin Immunol. 2015 Jun; 158(2):231-41.