"Receptors, Eph Family" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A large family of receptor protein-tyrosine kinases that are structurally-related. The name of this family of proteins derives from original protein Eph (now called the EPHA1 RECEPTOR), which was named after the cell line it was first discovered in: Erythropoietin-Producing human Hepatocellular carcinoma cell line. Members of this family have been implicated in regulation of cell-cell interactions involved in nervous system patterning and development.
| Descriptor ID |
D036081
|
| MeSH Number(s) |
D08.811.913.696.620.682.725.400.850 D12.776.543.750.630.500
|
| Concept/Terms |
Receptors, Eph Family- Receptors, Eph Family
- Eph Family Receptors
- Ephrin Receptors
- Receptors, Ephrin
- Eph Receptor Tyrosine Kinase
- Eph Receptors
- Receptors, Eph
Ephrin B Receptors- Ephrin B Receptors
- EphB Receptors
- Receptors, EphB
- EphB Receptor
- Ephrin B Receptor
- Receptor, Ephrin B
|
Below are MeSH descriptors whose meaning is more general than "Receptors, Eph Family".
Below are MeSH descriptors whose meaning is more specific than "Receptors, Eph Family".
- Receptors, Eph Family
- Receptor, EphA1
- Receptor, EphA2
- Receptor, EphA3
- Receptor, EphA4
- Receptor, EphA5
- Receptor, EphA6
- Receptor, EphA7
- Receptor, EphA8
- Receptor, EphB1
- Receptor, EphB2
- Receptor, EphB3
- Receptor, EphB4
- Receptor, EphB5
This graph shows the total number of publications written about "Receptors, Eph Family" by people in this website by year, and whether "Receptors, Eph Family" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1996 | 0 | 1 | 1 |
| 1998 | 0 | 1 | 1 |
| 2002 | 0 | 1 | 1 |
| 2004 | 1 | 0 | 1 |
| 2007 | 1 | 0 | 1 |
| 2008 | 1 | 0 | 1 |
| 2010 | 1 | 1 | 2 |
| 2014 | 1 | 0 | 1 |
| 2018 | 0 | 1 | 1 |
| 2022 | 1 | 0 | 1 |
| 2024 | 0 | 1 | 1 |
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Below are the most recent publications written about "Receptors, Eph Family" by people in Profiles.
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Identification of potent pan-ephrin receptor kinase inhibitors using DNA-encoded chemistry technology. Proc Natl Acad Sci U S A. 2024 May 07; 121(19):e2322934121.
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Ephrin receptor A10 monoclonal antibodies and the derived chimeric antigen receptor T cells exert an antitumor response in mouse models of triple-negative breast cancer. J Biol Chem. 2022 04; 298(4):101817.
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Juxtacrine Signaling Inhibits Antitumor Immunity by Upregulating PD-L1 Expression. Cancer Res. 2018 07 15; 78(14):3761-3768.
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Dynamic control of excitatory synapse development by a Rac1 GEF/GAP regulatory complex. Dev Cell. 2014 Jun 23; 29(6):701-15.
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EphB receptor forward signaling regulates area-specific reciprocal thalamic and cortical axon pathfinding. Proc Natl Acad Sci U S A. 2014 Feb 11; 111(6):2188-93.
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A chemical genetic approach reveals distinct EphB signaling mechanisms during brain development. Nat Neurosci. 2012 Dec; 15(12):1645-54.
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EphB-ephrin-B2 interactions are required for thymus migration during organogenesis. Proc Natl Acad Sci U S A. 2010 Jul 27; 107(30):13414-9.
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Aberrant DNA methylation and epigenetic inactivation of Eph receptor tyrosine kinases and ephrin ligands in acute lymphoblastic leukemia. Blood. 2010 Mar 25; 115(12):2412-9.
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The amyotrophic lateral sclerosis 8 protein VAPB is cleaved, secreted, and acts as a ligand for Eph receptors. Cell. 2008 Jun 13; 133(6):963-77.
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The Rac1 guanine nucleotide exchange factor Tiam1 mediates EphB receptor-dependent dendritic spine development. Proc Natl Acad Sci U S A. 2007 Apr 24; 104(17):7265-70.