"Receptor, trkA" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A protein-tyrosine kinase receptor that is specific for NERVE GROWTH FACTOR; NEUROTROPHIN 3; neurotrophin 4, neurotrophin 5. It plays a crucial role in pain sensation and thermoregulation in humans. Gene mutations that cause loss of receptor function are associated with CONGENITAL INSENSITIVITY TO PAIN WITH ANHIDROSIS, while gene rearrangements that activate the protein-tyrosine kinase function are associated with tumorigenesis.
| Descriptor ID |
D020917
|
| MeSH Number(s) |
D08.811.913.696.620.682.725.400.660 D12.776.543.750.630.496 D12.776.543.750.750.400.550.550
|
| Concept/Terms |
Receptor, trkA- Receptor, trkA
- Proto-Oncogene Protein trk
- Proto Oncogene Protein trk
- trk, Proto-Oncogene Protein
- gp140(c-TRK)
- trk Proto-Oncogene Protein
- Proto-Oncogene Protein, trk
- trk Proto Oncogene Protein
- NTRK1 Receptor
- Receptor, NTRK1
- Proto-Oncogene Products c-trk
- Proto Oncogene Products c trk
- c-trk, Proto-Oncogene Products
- c-trk Protein
- c trk Protein
- gp140 c-trk
- c-trk, gp140
- gp140 c trk
- p140-trkA
- p140 trkA
- trk1 Transforming Tryrosine Kinase
- Neurotrophic Tyrosine Kinase Receptor Type 1
- trkA Receptor
- Receptor, Neurotrophic Tyrosine Kinase Type 1
|
Below are MeSH descriptors whose meaning is more general than "Receptor, trkA".
Below are MeSH descriptors whose meaning is more specific than "Receptor, trkA".
This graph shows the total number of publications written about "Receptor, trkA" by people in this website by year, and whether "Receptor, trkA" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2001 | 0 | 3 | 3 |
| 2004 | 1 | 0 | 1 |
| 2007 | 2 | 0 | 2 |
| 2018 | 1 | 0 | 1 |
| 2022 | 1 | 1 | 2 |
| 2025 | 1 | 0 | 1 |
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Below are the most recent publications written about "Receptor, trkA" by people in Profiles.
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Clinical Characteristics and Outcomes of Central Nervous System Tumors Harboring NTRK Gene Fusions. Clin Cancer Res. 2025 Feb 03; 31(3):561-572.
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Q&A: Barriers to testing for NTRK fusions in metastatic lung and thyroid cancer. Clin Adv Hematol Oncol. 2024 Jul-Aug; 22 Suppl 5(6):16.
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Diagnosing NTRK fusions in lung and thyroid cancer. Clin Adv Hematol Oncol. 2024 Jul-Aug; 22 Suppl 5(6):2-5.
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Efficacy and safety of NTRK inhibitors in patients with NTRK fusion-positive lung and thyroid cancers. Clin Adv Hematol Oncol. 2024 Jul-Aug; 22 Suppl 5(6):1-20.
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Larotrectinib efficacy and safety in adult patients with tropomyosin receptor kinase fusion sarcomas. Cancer. 2023 12 01; 129(23):3772-3782.
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Diagnosis and Management of Tropomyosin Receptor Kinase Fusion-Positive Thyroid Carcinomas: A Review. JAMA Oncol. 2023 08 01; 9(8):1132-1141.
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A, B, C's of Trk Receptors and Their Ligands in Ocular Repair. Int J Mol Sci. 2022 Nov 15; 23(22).
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Standardized evidence-based approach for assessment of oncogenic and clinical significance of NTRK fusions. Cancer Genet. 2022 06; 264-265:50-59.
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NTRK Fusions Detection in Paediatric Sarcomas to Expand the Morphological Spectrum and Clinical Relevance of Selected Entities. Pathol Oncol Res. 2022; 28:1610237.
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Diagnostic testing approaches for the identification of patients with TRK fusion cancer prior to enrollment in clinical trials investigating larotrectinib. Cancer Genet. 2022 01; 260-261:46-52.