Receptor Tyrosine Kinase-like Orphan Receptors
"Receptor Tyrosine Kinase-like Orphan Receptors" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A family of cell surface receptors that were originally identified by their structural homology to neurotropic TYROSINE KINASES and referred to as orphan receptors because the associated ligand and signaling pathways were unknown. Evidence for the functionality of these proteins has been established by experiments showing that disruption of the orphan receptor genes results in developmental defects.
| Descriptor ID |
D057050
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| MeSH Number(s) |
D08.811.913.696.620.682.725.400.093 D12.776.543.750.630.233
|
| Concept/Terms |
Receptor Tyrosine Kinase-like Orphan Receptors- Receptor Tyrosine Kinase-like Orphan Receptors
- Receptor Tyrosine Kinase like Orphan Receptors
- Neurotrophic Tyrosine Kinase, Receptor-related Proteins
- Neurotrophic Tyrosine Kinase, Receptor related Proteins
- NTRKR Receptors
- ROR Tyrosine Kinase Receptors
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Below are MeSH descriptors whose meaning is more general than "Receptor Tyrosine Kinase-like Orphan Receptors".
Below are MeSH descriptors whose meaning is more specific than "Receptor Tyrosine Kinase-like Orphan Receptors".
This graph shows the total number of publications written about "Receptor Tyrosine Kinase-like Orphan Receptors" by people in this website by year, and whether "Receptor Tyrosine Kinase-like Orphan Receptors" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2007 | 0 | 1 | 1 |
| 2008 | 0 | 1 | 1 |
| 2009 | 0 | 1 | 1 |
| 2013 | 0 | 1 | 1 |
| 2015 | 1 | 0 | 1 |
| 2016 | 1 | 1 | 2 |
| 2017 | 1 | 0 | 1 |
| 2019 | 0 | 1 | 1 |
| 2020 | 2 | 1 | 3 |
| 2021 | 0 | 1 | 1 |
| 2022 | 2 | 0 | 2 |
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Below are the most recent publications written about "Receptor Tyrosine Kinase-like Orphan Receptors" by people in Profiles.
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Noncanonical Wnt/Ror2 signaling regulates cell-matrix adhesion to prompt directional tumor cell invasion in breast cancer. Mol Biol Cell. 2022 09 15; 33(11):ar103.
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Phenotypic and mutational spectrum of ROR2-related Robinow syndrome. Hum Mutat. 2022 07; 43(7):900-918.
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A proteogenomic portrait of lung squamous cell carcinoma. Cell. 2021 08 05; 184(16):4348-4371.e40.
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The Cell Surface Receptors Ror1/2 Control Cardiac Myofibroblast Differentiation. J Am Heart Assoc. 2021 07 06; 10(13):e019904.
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Loss of expression of both miR-15/16 loci in CML transition to blast crisis. Proc Natl Acad Sci U S A. 2021 03 16; 118(11).
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Conditional Ror1 knockout reveals crucial involvement in lung adenocarcinoma development and identifies novel HIF-1a regulator. Cancer Sci. 2021 Apr; 112(4):1614-1623.
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Inhibition of heat shock protein 90 destabilizes receptor tyrosine kinase ROR1 in lung adenocarcinoma. Cancer Sci. 2021 Mar; 112(3):1225-1234.
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Novel pathogenic genomic variants leading to autosomal dominant and recessive Robinow syndrome. Am J Med Genet A. 2021 12; 185(12):3593-3600.
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Characterization of the Robinow syndrome skeletal phenotype, bone micro-architecture, and genotype-phenotype correlations with the osteosclerotic form. Am J Med Genet A. 2020 11; 182(11):2632-2640.
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The receptor tyrosine kinase Ror is required for dendrite regeneration in Drosophila neurons. PLoS Biol. 2020 03; 18(3):e3000657.