Receptor Tyrosine Kinase-like Orphan Receptors
"Receptor Tyrosine Kinase-like Orphan Receptors" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A family of cell surface receptors that were originally identified by their structural homology to neurotropic TYROSINE KINASES and referred to as orphan receptors because the associated ligand and signaling pathways were unknown. Evidence for the functionality of these proteins has been established by experiments showing that disruption of the orphan receptor genes results in developmental defects.
| Descriptor ID |
D057050
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| MeSH Number(s) |
D08.811.913.696.620.682.725.400.093 D12.776.543.750.630.233
|
| Concept/Terms |
Receptor Tyrosine Kinase-like Orphan Receptors- Receptor Tyrosine Kinase-like Orphan Receptors
- Receptor Tyrosine Kinase like Orphan Receptors
- Neurotrophic Tyrosine Kinase, Receptor-related Proteins
- Neurotrophic Tyrosine Kinase, Receptor related Proteins
- NTRKR Receptors
- ROR Tyrosine Kinase Receptors
|
Below are MeSH descriptors whose meaning is more general than "Receptor Tyrosine Kinase-like Orphan Receptors".
Below are MeSH descriptors whose meaning is more specific than "Receptor Tyrosine Kinase-like Orphan Receptors".
This graph shows the total number of publications written about "Receptor Tyrosine Kinase-like Orphan Receptors" by people in this website by year, and whether "Receptor Tyrosine Kinase-like Orphan Receptors" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2007 | 0 | 1 | 1 |
| 2008 | 0 | 1 | 1 |
| 2009 | 0 | 1 | 1 |
| 2013 | 0 | 1 | 1 |
| 2015 | 1 | 0 | 1 |
| 2016 | 0 | 1 | 1 |
| 2017 | 1 | 0 | 1 |
| 2019 | 0 | 1 | 1 |
| 2020 | 1 | 1 | 2 |
| 2021 | 0 | 1 | 1 |
| 2022 | 2 | 0 | 2 |
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Below are the most recent publications written about "Receptor Tyrosine Kinase-like Orphan Receptors" by people in Profiles.
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Noncanonical Wnt/Ror2 signaling regulates cell-matrix adhesion to prompt directional tumor cell invasion in breast cancer. Mol Biol Cell. 2022 09 15; 33(11):ar103.
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Phenotypic and mutational spectrum of ROR2-related Robinow syndrome. Hum Mutat. 2022 07; 43(7):900-918.
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A proteogenomic portrait of lung squamous cell carcinoma. Cell. 2021 08 05; 184(16):4348-4371.e40.
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Novel pathogenic genomic variants leading to autosomal dominant and recessive Robinow syndrome. Am J Med Genet A. 2021 12; 185(12):3593-3600.
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Characterization of the Robinow syndrome skeletal phenotype, bone micro-architecture, and genotype-phenotype correlations with the osteosclerotic form. Am J Med Genet A. 2020 11; 182(11):2632-2640.
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Histoepigenetic analysis of HPV- and tobacco-associated head and neck cancer identifies both subtype-specific and common therapeutic targets despite divergent microenvironments. Oncogene. 2019 05; 38(19):3551-3568.
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Ror2-mediated alternative Wnt signaling regulates cell fate and adhesion during mammary tumor progression. Oncogene. 2017 10 26; 36(43):5958-5968.
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DVL3 Alleles Resulting in a -1 Frameshift of the Last Exon Mediate Autosomal-Dominant Robinow Syndrome. Am J Hum Genet. 2016 Mar 03; 98(3):553-561.
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Ror2 regulates branching, differentiation, and actin-cytoskeletal dynamics within the mammary epithelium. J Cell Biol. 2015 Feb 02; 208(3):351-66.
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Heterotrimeric G-protein, Ga16, is a critical downstream effector of non-canonical Wnt signaling and a potent inhibitor of transformed cell growth in non small cell lung cancer. PLoS One. 2013; 8(10):e76895.