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JOSEPH DUMAN

TitleAssociate Professor
InstitutionBaylor College of Medicine
DepartmentDepartment of Neuroscience
AddressOne Baylor Plaza
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    Collapse Research 
    Collapse research activities and funding
    R01CA283569     (DUMAN, JOSEPH G)Mar 1, 2024 - Feb 28, 2029
    NIH
    Molecular and cellular mechanisms of neuronal damage caused by anticancer therapies
    Role: Principal Investigator
    R01CA219667     (DUMAN, JOSEPH G)Sep 1, 2017 - Jul 31, 2022
    NIH
    (PQ9) Directed and unbiased studies of synaptic injuries as sequelae of radiotherapy: mapping, sex-dependence, and reversal
    Role: Principal Investigator
    K01MH086119     (DUMAN, JOSEPH G)Apr 1, 2010 - Feb 28, 2015
    NIH
    Mechanism of Brain-Specific Angiogenesis Inhibitor 1 (BAI1) in Neural Development
    Role: Principal Investigator
    F32DK068982     (DUMAN, JOSEPH G)Dec 1, 2005 - Nov 30, 2008
    NIH
    Calcium dynamics in secretory granule-containing cells
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Grosshans D, Thomas R, Zhang D, Cronkite C, Thomas R, Singh S, Bronk L, Morales R, Duman J. Subcellular functions of tau mediates repair response and synaptic homeostasis in injury. Res Sq. 2024 Feb 29. PMID: 38464175; PMCID: PMC10925419.
      Citations:    
    2. Duman JG, Blanco FA, Cronkite CA, Ru Q, Erikson KC, Mulherkar S, Saifullah AB, Firozi K, Tolias KF. Rac-maninoff and Rho-vel: The symphony of Rho-GTPase signaling at excitatory synapses. Small GTPases. 2022 01; 13(1):14-47. PMID: 33955328; PMCID: PMC9707551.
      Citations: 1     Fields:    
    3. Cheng J, Scala F, Blanco FA, Niu S, Firozi K, Keehan L, Mulherkar S, Froudarakis E, Li L, Duman JG, Jiang X, Tolias KF. The Rac-GEF Tiam1 Promotes Dendrite and Synapse Stabilization of Dentate Granule Cells and Restricts Hippocampal-Dependent Memory Functions. J Neurosci. 2021 02 10; 41(6):1191-1206. PMID: 33328293; PMCID: PMC7888217.
      Citations: 3     Fields:    Translation:AnimalsCells
    4. Zhang D, Zhou W, Lam TT, Li Y, Duman JG, Dougherty PM, Grosshans DR. Cranial irradiation induces axon initial segment dysfunction and neuronal injury in the prefrontal cortex and impairs hippocampal coupling. Neurooncol Adv. 2020 Jan-Dec; 2(1):vdaa058. PMID: 32642710; PMCID: PMC7260696.
      Citations: 1     
    5. Duman JG, Mulherkar S, Tu YK, Erikson KC, Tzeng CP, Mavratsas VC, Ho TS, Tolias KF. The adhesion-GPCR BAI1 shapes dendritic arbors via Bcr-mediated RhoA activation causing late growth arrest. Elife. 2019 08 28; 8. PMID: 31461398; PMCID: PMC6713510.
      Citations: 8     Fields:    Translation:AnimalsCells
    6. Wang L, Pang K, Han K, Adamski CJ, Wang W, He L, Lai JK, Bondar VV, Duman JG, Richman R, Tolias KF, Barth P, Palzkill T, Liu Z, Holder JL, Zoghbi HY. An autism-linked missense mutation in SHANK3 reveals the modularity of Shank3 function. Mol Psychiatry. 2020 10; 25(10):2534-2555. PMID: 30610205; PMCID: PMC6609509.
      Citations: 25     Fields:    Translation:HumansAnimalsCells
    7. Grosshans DR, Duman JG, Gaber MW, Sawakuchi G. Particle Radiation Induced Neurotoxicity in the Central Nervous System. Int J Part Ther. 2018; 5(1):74-83. PMID: 31773021; PMCID: PMC6871599.
      Citations: 3     
    8. Tu YK, Duman JG, Tolias KF. The Adhesion-GPCR BAI1 Promotes Excitatory Synaptogenesis by Coordinating Bidirectional Trans-synaptic Signaling. J Neurosci. 2018 09 26; 38(39):8388-8406. PMID: 30120207; PMCID: PMC6158688.
      Citations: 17     Fields:    Translation:AnimalsCells
    9. Zhang D, Zhou W, Lam TT, Weng C, Bronk L, Ma D, Wang Q, Duman JG, Dougherty PM, Grosshans DR. Radiation induces age-dependent deficits in cortical synaptic plasticity. Neuro Oncol. 2018 08 02; 20(9):1207-1214. PMID: 29660023; PMCID: PMC6107999.
      Citations: 9     Fields:    Translation:AnimalsCellsPHPublic Health
    10. Wilke C, Grosshans D, Duman J, Brown P, Li J. Radiation-induced cognitive toxicity: pathophysiology and interventions to reduce toxicity in adults. Neuro Oncol. 2018 04 09; 20(5):597-607. PMID: 29045710; PMCID: PMC5892147.
      Citations: 14     Fields:    Translation:HumansPHPublic Health
    11. Duman JG, Dinh J, Zhou W, Cham H, Mavratsas VC, Mulherkar S, McGovern SL, Tolias KF, Grosshans DR, Pave?kovic M. Memantine prevents acute radiation-induced toxicities at hippocampal excitatory synapses. Neuro Oncol. 2018 04 09; 20(5):655-665. PMID: 29112734; PMCID: PMC5892158.
      Citations: 15     Fields:    Translation:AnimalsCellsPHPublic Health
    12. Duman JG, Tolias KF. RhoGTPases Spread the Word for Synaptic Crosstalk. Dev Cell. 2016 10 24; 39(2):136-138. PMID: 27780038.
      Citations: 1     Fields:    Translation:HumansCells
    13. Duman JG, Tu YK, Tolias KF. Emerging Roles of BAI Adhesion-GPCRs in Synapse Development and Plasticity. Neural Plast. 2016; 2016:8301737. PMID: 26881134; PMCID: PMC4736325.
      Citations: 17     Fields:    Translation:HumansAnimalsCells
    14. Duman JG, Mulherkar S, Tu YK, X Cheng J, Tolias KF. Mechanisms for spatiotemporal regulation of Rho-GTPase signaling at synapses. Neurosci Lett. 2015 Aug 05; 601:4-10. PMID: 26003445; PMCID: PMC4513188.
      Citations: 27     Fields:    Translation:HumansAnimalsCells
    15. Liebscher I, Ackley B, Ariestanti DM, Aust G, Bae BI, Bista BR, Bridges JP, Duman JG, Engel FB, Giera S, Hall RA, Hartmann N, Lin HH, Liu M, Luo R, Mogha A, Monk KR, Peeters MC, Ressl S, Song H, Talbot WS, Tall GG, White JP, Wolfrum U, Xu L, Piao X, Ara? D, Goffinet AM, Hamann J, Pr?mel S, Schi?th HB, Sigoillot SM. New functions and signaling mechanisms for the class of adhesion G protein-coupled receptors. Ann N Y Acad Sci. 2014 Dec; 1333:43-64. PMID: 25424900; PMCID: PMC4278406.
      Citations: 9     Fields:    Translation:HumansAnimalsCells
    16. Um K, Niu S, Duman JG, Tu YK, Schwechter B, Liu F, Hiles L, Ash RT, Mulherkar S, Smirnakis SM, Cheng JX, Narayanan AS, Alpadi K, Tolias KF. Dynamic control of excitatory synapse development by a Rac1 GEF/GAP regulatory complex. Dev Cell. 2014 Jun 23; 29(6):701-15. PMID: 24960694; PMCID: PMC4111230.
      Citations: 41     Fields:    Translation:AnimalsCells
    17. Duman JG, Tzeng CP, Tu YK, Munjal T, Schwechter B, Ho TS, Tolias KF. The adhesion-GPCR BAI1 regulates synaptogenesis by controlling the recruitment of the Par3/Tiam1 polarity complex to synaptic sites. J Neurosci. 2013 Apr 17; 33(16):6964-78. PMID: 23595754; PMCID: PMC3670686.
      Citations: 64     Fields:    Translation:HumansAnimalsCells
    18. Dickson EJ, Duman JG, Moody MW, Chen L, Hille B. Orai-STIM-mediated Ca2+ release from secretory granules revealed by a targeted Ca2+ and pH probe. Proc Natl Acad Sci U S A. 2012 Dec 18; 109(51):E3539-48. PMID: 23184982; PMCID: PMC3529049.
      Citations: 27     Fields:    Translation:HumansCells
    19. Sathyanesan M, Girgenti MJ, Banasr M, Stone K, Bruce C, Guilchicek E, Wilczak-Havill K, Nairn A, Williams K, Sass S, Duman JG, Newton SS. A molecular characterization of the choroid plexus and stress-induced gene regulation. Transl Psychiatry. 2012 Jul 10; 2:e139. PMID: 22781172; PMCID: PMC3410626.
      Citations:    
    20. Tolias KF, Duman JG, Um K. Control of synapse development and plasticity by Rho GTPase regulatory proteins. Prog Neurobiol. 2011 Jul; 94(2):133-48. PMID: 21530608; PMCID: PMC3129138.
      Citations: 134     Fields:    Translation:HumansAnimalsCells
    21. Duman JG, Chen L, Hille B. Calcium transport mechanisms of PC12 cells. J Gen Physiol. 2008 Apr; 131(4):307-23. PMID: 18347082; PMCID: PMC2279173.
      Citations: 27     Fields:    Translation:AnimalsCells
    22. Duman JG, Chen L, Palmer AE, Hille B. Contributions of intracellular compartments to calcium dynamics: implicating an acidic store. Traffic. 2006 Jul; 7(7):859-72. PMID: 16787398.
      Citations: 18     Fields:    Translation:AnimalsCells
    23. Duman JG, Lee E, Lee GY, Singh G, Forte JG. Membrane fusion correlates with surface charge in exocytic vesicles. Biochemistry. 2004 Jun 22; 43(24):7924-39. PMID: 15196037.
      Citations:    
    24. Duman JG, Forte JG. What is the role of SNARE proteins in membrane fusion? Am J Physiol Cell Physiol. 2003 Aug; 285(2):C237-49. PMID: 12842832.
      Citations: 47     Fields:    Translation:HumansAnimalsCells
    25. Karvar S, Yao X, Duman JG, Hybiske K, Liu Y, Forte JG. Intracellular distribution and functional importance of vesicle-associated membrane protein 2 in gastric parietal cells. Gastroenterology. 2002 Jul; 123(1):281-90. PMID: 12105856.
      Citations: 9     Fields:    Translation:AnimalsCells
    26. Duman JG, Pathak NJ, Ladinsky MS, McDonald KL, Forte JG. Three-dimensional reconstruction of cytoplasmic membrane networks in parietal cells. J Cell Sci. 2002 Mar 15; 115(Pt 6):1251-8. PMID: 11884524.
      Citations: 15     Fields:    Translation:AnimalsCells
    27. Duman JG, Singh G, Lee GY, Machen TE, Forte JG. Ca(2+) and Mg(2+)/ATP independently trigger homotypic membrane fusion in gastric secretory membranes. Traffic. 2002 Mar; 3(3):203-17. PMID: 11886591.
      Citations: 3     Fields:    Translation:AnimalsCells
    28. Okamoto CT, Duman JG, Tyagarajan K, McDonald KL, Jeng YY, McKinney J, Forte TM, Forte JG. Clathrin in gastric acid secretory (parietal) cells: biochemical characterization and subcellular localization. Am J Physiol Cell Physiol. 2000 Sep; 279(3):C833-51. PMID: 10942733.
      Citations: 7     Fields:    Translation:AnimalsCells
    29. Duman JG, Tyagarajan K, Kolsi MS, Moore HP, Forte JG. Expression of rab11a N124I in gastric parietal cells inhibits stimulatory recruitment of the H+-K+-ATPase. Am J Physiol. 1999 09; 277(3):C361-72. PMID: 10484323.
      Citations: 23     Fields:    Translation:HumansAnimalsCells
    30. Agnew BJ, Duman JG, Watson CL, Coling DE, Forte JG. Cytological transformations associated with parietal cell stimulation: critical steps in the activation cascade. J Cell Sci. 1999 Aug; 112 ( Pt 16):2639-46. PMID: 10413672.
      Citations: 20     Fields:    Translation:AnimalsCells
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