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PAUL PFAFFINGER

TitleProfessor
InstitutionBaylor College of Medicine
DepartmentDepartment of Neuroscience
AddressOne Baylor Plaza
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    Other Positions
    TitleInterim Chair
    InstitutionBaylor College of Medicine
    DepartmentDepartment of Neuroscience
    DivisionNeuroscience


    Collapse Research 
    Collapse research activities and funding
    U01NS111692     (PFAFFINGER, PAUL)May 15, 2019 - Apr 30, 2022
    NIH/NINDS
    Multilevel Analysis of Neuronal Computations Underlying the Robust Encoding of Sensory Information in the Mammalian Olfactory System
    Role: Principal Investigator
    UF1NS111692     (PFAFFINGER, PAUL)May 15, 2019 - Apr 30, 2022
    NIH
    Multilevel Analysis of Neuronal Computations Underlying the Robust Encoding of Sensory Information in the Mammalian Olfactory System
    Role: Principal Investigator
    R01NS076708     (PFAFFINGER, PAUL)Mar 15, 2012 - Mar 31, 2026
    NIH
    The integrated stress response in cognitive disorders
    Role: Principal Investigator
    R01GM090029     (PFAFFINGER, PAUL)Jan 1, 2010 - Dec 31, 2015
    NIH
    A Current Regulation by Dipeptidyl Peptidase-Like Proteins
    Role: Principal Investigator
    R01NS031583     (PFAFFINGER, PAUL)May 1, 1993 - Nov 30, 2004
    NIH
    FUNCTIONAL DOMAINS OF K+ CHANNEL SUBUNIT PROTEINS
    Role: Principal Investigator
    P30HD024064     (ZOGHBI, HUDA Y)Aug 1, 1988 - Dec 30, 2014
    NIH
    Baylor Intellectual and Developmental Disabilities Research Center
    Role: Co-Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Jerng HH, Silva-P?rez M, David LS, Chin J, Krishnan V, Pfaffinger PJ. Kv4.2V404M Mutation Induces Epileptiform Activity and Multiple Behavioral Abnormalities in Heterozygous Knock-in Mice. J Neurosci. 2026 02 11; 46(6). PMID: 41554648; PMCID: PMC12896680.
      Citations:    Fields:    Translation:Animals
    2. Jerng HH, Patel JM, Khan TA, Arenkiel BR, Pfaffinger PJ. Light-regulated voltage-gated potassium channels for acute interrogation of channel function in neurons and behavior. PLoS One. 2021; 16(3):e0248688. PMID: 33755670; PMCID: PMC7987177.
      Citations:    Fields:    Translation:HumansAnimalsCells
    3. Jerng HH, Pfaffinger PJ. Modulatory mechanisms and multiple functions of somatodendritic A-type K (+) channel auxiliary subunits. Front Cell Neurosci. 2014; 8:82. PMID: 24723849; PMCID: PMC3973911.
      Citations: 31     
    4. Jerng HH, Pfaffinger PJ. S-glutathionylation of an auxiliary subunit confers redox sensitivity to Kv4 channel inactivation. PLoS One. 2014; 9(3):e93315. PMID: 24675763; PMCID: PMC3968176.
      Citations: 6     Fields:    Translation:HumansAnimalsCells
    5. Pfaffinger PJ. A conserved pre-block interaction motif regulates potassium channel activation and N-type inactivation. PLoS One. 2013; 8(11):e79891. PMID: 24236164; PMCID: PMC3827413.
      Citations:    Fields:    Translation:AnimalsCells
    6. Kunjilwar K, Qian Y, Pfaffinger PJ. Functional stoichiometry underlying KChIP regulation of Kv4.2 functional expression. J Neurochem. 2013 Aug; 126(4):462-72. PMID: 23692269; PMCID: PMC3737270.
      Citations: 7     Fields:    Translation:AnimalsCells
    7. Prince A, Pfaffinger PJ. Conserved N-terminal negative charges support optimally efficient N-type inactivation of Kv1 channels. PLoS One. 2013; 8(4):e62695. PMID: 23638135; PMCID: PMC3634772.
      Citations: 2     Fields:    Translation:AnimalsCells
    8. Nadin BM, Pfaffinger PJ. A new TASK for Dipeptidyl Peptidase-like Protein 6. PLoS One. 2013; 8(4):e60831. PMID: 23593319; PMCID: PMC3621905.
      Citations: 5     Fields:    Translation:AnimalsCells
    9. Jerng HH, Pfaffinger PJ. Incorporation of DPP6a and DPP6K variants in ternary Kv4 channel complex reconstitutes properties of A-type K current in rat cerebellar granule cells. PLoS One. 2012; 7(6):e38205. PMID: 22675523; PMCID: PMC3366920.
      Citations: 11     Fields:    Translation:AnimalsCells
    10. Nadin BM, Pfaffinger PJ. Dipeptidyl peptidase-like protein 6 is required for normal electrophysiological properties of cerebellar granule cells. J Neurosci. 2010 Jun 23; 30(25):8551-65. PMID: 20573902; PMCID: PMC2916862.
      Citations: 21     Fields:    Translation:HumansCells
    11. Jerng HH, Dougherty K, Covarrubias M, Pfaffinger PJ. A novel N-terminal motif of dipeptidyl peptidase-like proteins produces rapid inactivation of KV4.2 channels by a pore-blocking mechanism. Channels (Austin). 2009 Nov; 3(6):448-61. PMID: 19901547; PMCID: PMC3607289.
      Citations: 17     Fields:    Translation:AnimalsCells
    12. Prince-Carter A, Pfaffinger PJ. Multiple intermediate states precede pore block during N-type inactivation of a voltage-gated potassium channel. J Gen Physiol. 2009 Jul; 134(1):15-34. PMID: 19528261; PMCID: PMC2712980.
      Citations: 8     Fields:    Translation:AnimalsCells
    13. Jerng HH, Pfaffinger PJ. Multiple Kv channel-interacting proteins contain an N-terminal transmembrane domain that regulates Kv4 channel trafficking and gating. J Biol Chem. 2008 Dec 19; 283(51):36046-59. PMID: 18957440; PMCID: PMC2602920.
      Citations: 22     Fields:    Translation:HumansAnimalsCells
    14. Jerng HH, Lauver AD, Pfaffinger PJ. DPP10 splice variants are localized in distinct neuronal populations and act to differentially regulate the inactivation properties of Kv4-based ion channels. Mol Cell Neurosci. 2007 Aug; 35(4):604-24. PMID: 17475505; PMCID: PMC3674967.
      Citations: 26     Fields:    Translation:HumansAnimalsCells
    15. Wang G, Strang C, Pfaffinger PJ, Covarrubias M. Zn2+-dependent redox switch in the intracellular T1-T1 interface of a Kv channel. J Biol Chem. 2007 May 04; 282(18):13637-47. PMID: 17331952; PMCID: PMC2211274.
      Citations: 19     Fields:    Translation:AnimalsCells
    16. Lauver A, Yuan LL, Jeromin A, Nadin BM, Davies HA, Stewart MG, Wu GY, Pfaffinger PJ, Rodr?guez JJ. Manipulating Kv4.2 identifies a specific component of hippocampal pyramidal neuron A-current that depends upon Kv4.2 expression. J Neurochem. 2006 Nov; 99(4):1207-23. PMID: 17026528; PMCID: PMC3583589.
      Citations: 13     Fields:    Translation:AnimalsCells
    17. Lu CW, Lin JH, Rajawat YS, Jerng H, Rami TG, Sanchez X, DeFreitas G, Carabello B, DeMayo F, Kearney DL, Miller G, Li H, Pfaffinger PJ, Bowles NE, Khoury DS, Towbin JA. Functional and clinical characterization of a mutation in KCNJ2 associated with Andersen-Tawil syndrome. J Med Genet. 2006 Aug; 43(8):653-9. PMID: 16571646; PMCID: PMC2564587.
      Citations: 12     Fields:    Translation:HumansAnimalsCells
    18. Ren Y, Barnwell LF, Alexander JC, Lubin FD, Adelman JP, Pfaffinger PJ, Schrader LA, Anderson AE. Regulation of surface localization of the small conductance Ca2+-activated potassium channel, Sk2, through direct phosphorylation by cAMP-dependent protein kinase. J Biol Chem. 2006 Apr 28; 281(17):11769-79. PMID: 16513649.
      Citations: 48     Fields:    Translation:AnimalsCells
    19. Baker KA, Hilty C, Peti W, Prince A, Pfaffinger PJ, Wider G, Choe S, W?thrich K. NMR-derived dynamic aspects of N-type inactivation of a Kv channel suggest a transient interaction with the T1 domain. Biochemistry. 2006 Feb 14; 45(6):1663-72. PMID: 16460013; PMCID: PMC3508000.
      Citations: 12     Fields:    Translation:HumansAnimalsCells
    20. Yuan LL, Chen X, Kunjilwar K, Pfaffinger P, Johnston D. Acceleration of K+ channel inactivation by MEK inhibitor U0126. Am J Physiol Cell Physiol. 2006 Jan; 290(1):C165-71. PMID: 16135544.
      Citations: 10     Fields:    Translation:AnimalsCells
    21. Jerng HH, Kunjilwar K, Pfaffinger PJ. Multiprotein assembly of Kv4.2, KChIP3 and DPP10 produces ternary channel complexes with ISA-like properties. J Physiol. 2005 Nov 01; 568(Pt 3):767-88. PMID: 16123112; PMCID: PMC1464192.
      Citations: 81     Fields:    Translation:AnimalsCells
    22. Wang G, Shahidullah M, Rocha CA, Strang C, Pfaffinger PJ, Covarrubias M. Functionally active t1-t1 interfaces revealed by the accessibility of intracellular thiolate groups in kv4 channels. J Gen Physiol. 2005 Jul; 126(1):55-69. PMID: 15955876; PMCID: PMC2266617.
      Citations: 19     Fields:    Translation:AnimalsCells
    23. Jerng HH, Pfaffinger PJ, Covarrubias M. Molecular physiology and modulation of somatodendritic A-type potassium channels. Mol Cell Neurosci. 2004 Dec; 27(4):343-69. PMID: 15555915.
      Citations: 161     Fields:    Translation:HumansAnimalsCells
    24. Kunjilwar K, Strang C, DeRubeis D, Pfaffinger PJ. KChIP3 rescues the functional expression of Shal channel tetramerization mutants. J Biol Chem. 2004 Dec 24; 279(52):54542-51. PMID: 15485870.
      Citations: 27     Fields:    Translation:AnimalsCells
    25. Jerng HH, Qian Y, Pfaffinger PJ. Modulation of Kv4.2 channel expression and gating by dipeptidyl peptidase 10 (DPP10). Biophys J. 2004 Oct; 87(4):2380-96. PMID: 15454437; PMCID: PMC1304660.
      Citations: 62     Fields:    Translation:HumansAnimalsCells
    26. Zhou W, Qian Y, Kunjilwar K, Pfaffinger PJ, Choe S. Structural insights into the functional interaction of KChIP1 with Shal-type K(+) channels. Neuron. 2004 Feb 19; 41(4):573-86. PMID: 14980206.
      Citations: 57     Fields:    Translation:AnimalsCells
    27. Jeromin A, Yuan LL, Frick A, Pfaffinger P, Johnston D. A modified Sindbis vector for prolonged gene expression in neurons. J Neurophysiol. 2003 Oct; 90(4):2741-5. PMID: 12853440.
      Citations: 19     Fields:    Translation:AnimalsCells
    28. Nanao MH, Zhou W, Pfaffinger PJ, Choe S. Determining the basis of channel-tetramerization specificity by x-ray crystallography and a sequence-comparison algorithm: Family Values (FamVal). Proc Natl Acad Sci U S A. 2003 Jul 22; 100(15):8670-5. PMID: 12835418; PMCID: PMC166370.
      Citations: 20     Fields:    Translation:AnimalsCells
    29. Strang C, Kunjilwar K, DeRubeis D, Peterson D, Pfaffinger PJ. The role of Zn2+ in Shal voltage-gated potassium channel formation. J Biol Chem. 2003 Aug 15; 278(33):31361-71. PMID: 12754210.
      Citations: 10     Fields:    Translation:AnimalsCells
    30. Schrader LA, Anderson AE, Mayne A, Pfaffinger PJ, Sweatt JD. PKA modulation of Kv4.2-encoded A-type potassium channels requires formation of a supramolecular complex. J Neurosci. 2002 Dec 01; 22(23):10123-33. PMID: 12451113; PMCID: PMC6758737.
      Citations: 47     Fields:    Translation:AnimalsCells
    31. Jahng AW, Strang C, Kaiser D, Pollard T, Pfaffinger P, Choe S. Zinc mediates assembly of the T1 domain of the voltage-gated K channel 4.2. J Biol Chem. 2002 Dec 06; 277(49):47885-90. PMID: 12372826.
      Citations: 17     Fields:    Translation:Cells
    32. Choe S, Cushman S, Baker KA, Pfaffinger P. Excitability is mediated by the T1 domain of the voltage-gated potassium channel. Novartis Found Symp. 2002; 245:169-75; discussion 175-7, 261-4. PMID: 12027006.
      Citations: 3     Fields:    Translation:AnimalsCells
    33. Strang C, Cushman SJ, DeRubeis D, Peterson D, Pfaffinger PJ. A central role for the T1 domain in voltage-gated potassium channel formation and function. J Biol Chem. 2001 Jul 27; 276(30):28493-502. PMID: 11312262.
      Citations: 24     Fields:    Translation:AnimalsCells
    34. Adams JP, Anderson AE, Varga AW, Dineley KT, Cook RG, Pfaffinger PJ, Sweatt JD. The A-type potassium channel Kv4.2 is a substrate for the mitogen-activated protein kinase ERK. J Neurochem. 2000 Dec; 75(6):2277-87. PMID: 11080179.
      Citations: 108     Fields:    Translation:AnimalsCells
    35. Cushman SJ, Nanao MH, Jahng AW, DeRubeis D, Choe S, Pfaffinger PJ. Voltage dependent activation of potassium channels is coupled to T1 domain structure. Nat Struct Biol. 2000 May; 7(5):403-7. PMID: 10802739.
      Citations: 45     Fields:    Translation:AnimalsCells
    36. Anderson AE, Adams JP, Qian Y, Cook RG, Pfaffinger PJ, Sweatt JD. Kv4.2 phosphorylation by cyclic AMP-dependent protein kinase. J Biol Chem. 2000 Feb 25; 275(8):5337-46. PMID: 10681507.
      Citations: 54     Fields:    Translation:AnimalsCells
    37. Choe S, Kreusch A, Pfaffinger PJ. Towards the three-dimensional structure of voltage-gated potassium channels. Trends Biochem Sci. 1999 Sep; 24(9):345-9. PMID: 10470033.
      Citations: 16     Fields:    Translation:AnimalsCells
    38. Sutherland ML, Williams SH, Abedi R, Overbeek PA, Pfaffinger PJ, Noebels JL. Overexpression of a Shaker-type potassium channel in mammalian central nervous system dysregulates native potassium channel gene expression. Proc Natl Acad Sci U S A. 1999 Mar 02; 96(5):2451-5. PMID: 10051663; PMCID: PMC26805.
      Citations: 13     Fields:    Translation:HumansAnimalsCells
    39. Bixby KA, Nanao MH, Shen NV, Kreusch A, Bellamy H, Pfaffinger PJ, Choe S. Zn2+-binding and molecular determinants of tetramerization in voltage-gated K+ channels. Nat Struct Biol. 1999 Jan; 6(1):38-43. PMID: 9886290.
      Citations: 74     Fields:    Translation:HumansAnimalsCells
    40. Kreusch A, Pfaffinger PJ, Stevens CF, Choe S. Crystal structure of the tetramerization domain of the Shaker potassium channel. Nature. 1998 Apr 30; 392(6679):945-8. PMID: 9582078.
      Citations: 90     Fields:    Translation:Cells
    41. Pfaffinger PJ, DeRubeis D. Shaker K+ channel T1 domain self-tetramerizes to a stable structure. J Biol Chem. 1995 Dec 01; 270(48):28595-600. PMID: 7499375.
      Citations: 14     Fields:    
    42. Shen NV, Pfaffinger PJ. Molecular recognition and assembly sequences involved in the subfamily-specific assembly of voltage-gated K+ channel subunit proteins. Neuron. 1995 Mar; 14(3):625-33. PMID: 7695909.
      Citations: 67     Fields:    Translation:AnimalsCells
    43. Shen NV, Chen X, Boyer MM, Pfaffinger PJ. Deletion analysis of K+ channel assembly. Neuron. 1993 Jul; 11(1):67-76. PMID: 8338669.
      Citations: 63     Fields:    Translation:AnimalsCells
    44. Furukawa Y, Kandel ER, Pfaffinger P. Three types of early transient potassium currents in Aplysia neurons. J Neurosci. 1992 Mar; 12(3):989-1000. PMID: 1545247; PMCID: PMC6576028.
      Citations: 9     Fields:    Translation:AnimalsCells
    45. Kaang BK, Pfaffinger PJ, Grant SG, Kandel ER, Furukawa Y. Overexpression of an Aplysia shaker K+ channel gene modifies the electrical properties and synaptic efficacy of identified Aplysia neurons. Proc Natl Acad Sci U S A. 1992 Feb 01; 89(3):1133-7. PMID: 1310540; PMCID: PMC48400.
      Citations: 24     Fields:    Translation:AnimalsCells
    46. Pfaffinger PJ, Furukawa Y, Zhao B, Dugan D, Kandel ER. Cloning and expression of an Aplysia K+ channel and comparison with native Aplysia K+ currents. J Neurosci. 1991 Apr; 11(4):918-27. PMID: 2010814; PMCID: PMC6575383.
      Citations: 21     Fields:    Translation:AnimalsCells
    47. Bosma MM, Bernheim L, Leibowitz MD, Pfaffinger PJ, Hille B. Modulation of M current in frog sympathetic ganglion cells. Soc Gen Physiol Ser. 1990; 45:43-59. PMID: 2165636.
      Citations: 5     Fields:    Translation:AnimalsCells
    48. Pfaffinger P. Muscarine and t-LHRH suppress M-current by activating an IAP-insensitive G-protein. J Neurosci. 1988 Sep; 8(9):3343-53. PMID: 3139847; PMCID: PMC6569448.
      Citations: 32     Fields:    Translation:AnimalsCells
    49. Pfaffinger PJ, Leibowitz MD, Subers EM, Nathanson NM, Almers W, Hille B. Agonists that suppress M-current elicit phosphoinositide turnover and Ca2+ transients, but these events do not explain M-current suppression. Neuron. 1988 Aug; 1(6):477-84. PMID: 2483099.
      Citations: 39     Fields:    Translation:AnimalsCells
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