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PETER SAGGAU

TitleProfessor Emeritus
InstitutionBaylor College of Medicine
DepartmentDepartment of Neuroscience
AddressOne Baylor Plaza
Houston, TX 77030
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    Collapse Research 
    Collapse research activities and funding
    R21EB016223     (TOLIAS, ANDREAS)Jul 1, 2013 - Jun 30, 2015
    NIH
    ALL-OPTICAL HIGH-THROUGHPUT FUNCTIONAL CONNECTIVITY MAPPING USING ADVANCED MICROS
    Role: Co-Principal Investigator
    R21RR025365     (SAGGAU, PETER)Sep 1, 2010 - Aug 31, 2013
    NIH
    Super-resolution Workstation for Imaging Live Biological Nanostructure
    Role: Principal Investigator
    R01DA028525     (SAGGAU, PETER)Aug 15, 2009 - Jul 31, 2012
    NIH
    Optogenetic Tools for in vivo Analysis of Cortical Circuit Plasticity
    Role: Principal Investigator
    T32EB006350     (SAGGAU, PETER)Jul 1, 2007 - Jun 30, 2013
    NIH
    Training in Theoretical and Computational Neuroscience
    Role: Principal Investigator
    R01AG027577     (SAGGAU, PETER)Sep 15, 2005 - Jul 31, 2010
    NIH
    Computational and Optical Studies of Neural Input/Output Relationship
    Role: Principal Investigator
    R01EB001048     (SAGGAU, PETER)Sep 30, 2002 - Aug 31, 2006
    NIH
    Reconstruction &Imaging of Living Nerve Cells
    Role: Principal Investigator
    R01NS033147     (SAGGAU, PETER)Aug 1, 1995 - Mar 31, 2004
    NIH
    CA++ &PRESYNAPTIC MODULATION--SYNAPTIC TRANSMISSION
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Marchese A, Ricci P, Saggau P, Duocastella M. Scan-less microscopy based on acousto-optic encoded illumination. Nanophotonics. 2024 Jan; 13(1):63-73. PMID: 38235070; PMCID: PMC10790963.
      Citations:    
    2. Liu R, Ball N, Brockill J, Kuan L, Millman D, White C, Leon A, Williams D, Nishiwaki S, de Vries S, Larkin J, Sullivan D, Slaughterbeck C, Farrell C, Saggau P. Aberration-free multi-plane imaging of neural activity from the mammalian brain using a fast-switching liquid crystal spatial light modulator. Biomed Opt Express. 2019 Oct 01; 10(10):5059-5080. PMID: 31646030; PMCID: PMC6788611.
      Citations: 10     
    3. Tsyboulski D, Orlova N, Ledochowitsch P, Saggau P. Two-photon frequency division multiplexing for functional in vivo imaging: a feasibility study. Opt Express. 2019 Feb 18; 27(4):4488-4503. PMID: 30876067.
      Citations: 1     Fields:    Translation:AnimalsCells
    4. Long B, Zhou Z, Cetin A, Ting J, Gwinn R, Tasic B, Daigle T, Lein E, Zeng H, Saggau P, Hawrylycz M, Peng H. SmartScope2: Simultaneous Imaging and Reconstruction of Neuronal Morphology. Sci Rep. 2017 08 24; 7(1):9325. PMID: 28839271; PMCID: PMC5571186.
      Citations: 3     Fields:    Translation:HumansAnimalsCells
    5. Tsyboulski D, Orlova N, Saggau P. Amplitude modulation of femtosecond laser pulses in the megahertz range for frequency-multiplexed two-photon imaging. Opt Express. 2017 Apr 17; 25(8):9435-9442. PMID: 28437905.
      Citations: 3     Fields:    
    6. Quast KB, Ung K, Froudarakis E, Huang L, Herman I, Addison AP, Ortiz-Guzman J, Cordiner K, Saggau P, Tolias AS, Arenkiel BR. Developmental broadening of inhibitory sensory maps. Nat Neurosci. 2017 02; 20(2):189-199. PMID: 28024159; PMCID: PMC5510602.
      Citations: 22     Fields:    Translation:AnimalsCells
    7. Huang L, Ung K, Garcia I, Quast KB, Cordiner K, Saggau P, Arenkiel BR. Task Learning Promotes Plasticity of Interneuron Connectivity Maps in the Olfactory Bulb. J Neurosci. 2016 08 24; 36(34):8856-71. PMID: 27559168; PMCID: PMC4995301.
      Citations: 24     Fields:    Translation:AnimalsCells
    8. Saggau P, Arenkiel BR, Soiza-Reilly M. Neural circuits revealed. Front Neural Circuits. 2015; 9:35. PMID: 26283927; PMCID: PMC4516880.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    9. Hernandez-Herrera P, Papadakis M, Saggau P, Kakadiaris IA, Santamar?a-Pang A. Automatic Morphological Reconstruction of Neurons from Multiphoton and Confocal Microscopy Images Using 3D Tubular Models. Neuroinformatics. 2015 Jul; 13(3):297-320. PMID: 25631538.
      Citations: 18     Fields:    Translation:HumansAnimalsCells
    10. Jaafari N, Vogt KE, Saggau P, Leslie LM, Zecevic D, Canepari M. Combining Membrane Potential Imaging with Other Optical Techniques. Adv Exp Med Biol. 2015; 859:103-25. PMID: 26238050; PMCID: PMC5675139.
      Citations: 4     Fields:    Translation:AnimalsCells
    11. Reddy GD, Cotton RJ, Tolias AS, Saggau P. Random-Access Multiphoton Microscopy for Fast Three-Dimensional Imaging. Adv Exp Med Biol. 2015; 859:455-72. PMID: 26238064.
      Citations: 2     Fields:    Translation:AnimalsCells
    12. Matias CM, Saggau P, Quinta-Ferreira ME, Dion?sio JC. Activation of group II metabotropic glutamate receptors blocks zinc release from hippocampal mossy fibers. Biol Res. 2014 Dec 18; 47:73. PMID: 25723955; PMCID: PMC4289587.
      Citations:    Fields:    Translation:AnimalsCells
    13. Froudarakis E, Cotton RJ, Yatsenko D, Saggau P, Berens P, Ecker AS, Sinz FH, Bethge M, Tolias AS. Population code in mouse V1 facilitates readout of natural scenes through increased sparseness. Nat Neurosci. 2014 Jun; 17(6):851-7. PMID: 24747577; PMCID: PMC4106281.
      Citations: 74     Fields:    Translation:Animals
    14. Cotton RJ, Froudarakis E, Storer P, Saggau P, Tolias AS. Three-dimensional mapping of microcircuit correlation structure. Front Neural Circuits. 2013; 7:151. PMID: 24133414; PMCID: PMC3794294.
      Citations: 30     Fields:    Translation:AnimalsCells
    15. Bansal V, Saggau P. Digital micromirror devices: principles and applications in imaging. Cold Spring Harb Protoc. 2013 May 01; 2013(5):404-11. PMID: 23637366.
      Citations: 4     Fields:    
    16. Reddy GD, Saggau P. High-speed two-photon imaging. Cold Spring Harb Protoc. 2013 Jan 01; 2013(1). PMID: 23282635.
      Citations: 1     Fields:    
    17. Losavio BE, Iyer V, Patel S, Saggau P. Acousto-optic laser scanning for multi-site photo-stimulation of single neurons in vitro. J Neural Eng. 2010 Aug; 7(4):045002. PMID: 20644249.
      Citations: 6     Fields:    Translation:AnimalsCells
    18. Matias CM, Saggau P, Quinta-Ferreira ME. Blockade of presynaptic K ATP channels reduces the zinc-mediated posttetanic depression at hippocampal mossy fiber synapses. Brain Res. 2010 Mar 12; 1320:22-7. PMID: 20097182.
      Citations: 2     Fields:    Translation:AnimalsCells
    19. Yuan T, Gao SS, Saggau P, Oghalai JS. Calcium imaging of inner ear hair cells within the cochlear epithelium of mice using two-photon microscopy. J Biomed Opt. 2010 Jan-Feb; 15(1):016002. PMID: 20210449; PMCID: PMC2821419.
      Citations: 10     Fields:    Translation:AnimalsCells
    20. Losavio BE, Iyer V, Saggau P. Two-photon microscope for multisite microphotolysis of caged neurotransmitters in acute brain slices. J Biomed Opt. 2009 Nov-Dec; 14(6):064033. PMID: 20059271; PMCID: PMC2809696.
      Citations: 5     Fields:    Translation:AnimalsCells
    21. Gliko O, Saggau P, Brownell WE. Compartmentalization of the outer hair cell demonstrated by slow diffusion in the extracisternal space. Biophys J. 2009 Aug 19; 97(4):1215-24. PMID: 19686670; PMCID: PMC2726316.
      Citations:    Fields:    Translation:Cells
    22. Mancuso JJ, Larson AM, Wensel TG, Saggau P. Multiphoton adaptation of a commercial low-cost confocal microscope for live tissue imaging. J Biomed Opt. 2009 May-Jun; 14(3):034048. PMID: 19566340; PMCID: PMC3651892.
      Citations: 6     Fields:    Translation:HumansAnimalsCells
    23. Gliko O, Brownell WE, Saggau P. Fast two-dimensional standing-wave total-internal-reflection fluorescence microscopy using acousto-optic deflectors. Opt Lett. 2009 Mar 15; 34(6):836-8. PMID: 19282949.
      Citations: 1     Fields:    
    24. Losavio BE, Liang Y, Kakadiaris IA, Colbert CM, Saggau P, Santamar?a-Pang A. Live neuron morphology automatically reconstructed from multiphoton and confocal imaging data. J Neurophysiol. 2008 Oct; 100(4):2422-9. PMID: 18701753.
      Citations: 16     Fields:    Translation:AnimalsCells
    25. Duemani Reddy G, Kelleher K, Fink R, Saggau P. Three-dimensional random access multiphoton microscopy for functional imaging of neuronal activity. Nat Neurosci. 2008 Jun; 11(6):713-20. PMID: 18432198; PMCID: PMC2747788.
      Citations: 136     Fields:    Translation:AnimalsCells
    26. Colbert CM, Saggau P, Kakadiaris IA, Santamar?a-Pang A. Automatic centerline extraction of irregular tubular structures using probability volumes from multiphoton imaging. Med Image Comput Comput Assist Interv. 2007; 10(Pt 2):486-94. PMID: 18044604.
      Citations: 10     Fields:    Translation:HumansCells
    27. Gliko O, Reddy GD, Anvari B, Brownell WE, Saggau P. Standing wave total internal reflection fluorescence microscopy to measure the size of nanostructures in living cells. J Biomed Opt. 2006 Nov-Dec; 11(6):064013. PMID: 17212536.
      Citations: 6     Fields:    Translation:Cells
    28. Saggau P. New methods and uses for fast optical scanning. Curr Opin Neurobiol. 2006 Oct; 16(5):543-50. PMID: 16962769.
      Citations: 14     Fields:    Translation:HumansAnimalsCells
    29. Bansal V, Patel S, Saggau P. High-speed addressable confocal microscopy for functional imaging of cellular activity. J Biomed Opt. 2006 May-Jun; 11(3):34003. PMID: 16822053.
      Citations: 3     Fields:    Translation:AnimalsCells
    30. Nakagawa T, Oghalai JS, Saggau P, Rabbitt RD, Brownell WE. Photometric recording of transmembrane potential in outer hair cells. J Neural Eng. 2006 Jun; 3(2):79-86. PMID: 16705263; PMCID: PMC2716392.
      Citations: 8     Fields:    Translation:AnimalsCells
    31. Losavio BE, Reddy GD, Colbert CM, Kakadiaris IA, Saggau P. Combining optical imaging and computational modeling to analyze structure and function of living neurons. Conf Proc IEEE Eng Med Biol Soc. 2006; 2006:668-70. PMID: 17946849.
      Citations: 2     Fields:    Translation:AnimalsCells
    32. Reddy GD, Saggau P. Fast three-dimensional laser scanning scheme using acousto-optic deflectors. J Biomed Opt. 2005 Nov-Dec; 10(6):064038. PMID: 16409103.
      Citations: 42     Fields:    
    33. Iyer V, Hoogland TM, Saggau P. Fast functional imaging of single neurons using random-access multiphoton (RAMP) microscopy. J Neurophysiol. 2006 Jan; 95(1):535-45. PMID: 16221746.
      Citations: 46     Fields:    Translation:AnimalsCells
    34. Hoogland TM, Saggau P. Facilitation of L-type Ca2+ channels in dendritic spines by activation of beta2 adrenergic receptors. J Neurosci. 2004 Sep 29; 24(39):8416-27. PMID: 15456814; PMCID: PMC6729902.
      Citations: 47     Fields:    Translation:AnimalsCells
    35. Uehara C, Colbert C, Saggau P, Kakadiaris I. Towards automatic reconstruction of dendrite morphology from live neurons. Conf Proc IEEE Eng Med Biol Soc. 2004; 2004:1798-801. PMID: 17272057.
      Citations: 2     Fields:    
    36. Iyer V, Losavio BE, Saggau P. Compensation of spatial and temporal dispersion for acousto-optic multiphoton laser-scanning microscopy. J Biomed Opt. 2003 Jul; 8(3):460-71. PMID: 12880352.
      Citations: 26     Fields:    
    37. McQuiston AR, Saggau P. Mu-opioid receptors facilitate the propagation of excitatory activity in rat hippocampal area CA1 by disinhibition of all anatomical layers. J Neurophysiol. 2003 Sep; 90(3):1936-48. PMID: 12750411.
      Citations: 24     Fields:    Translation:Animals
    38. Levy M, Faas GC, Saggau P, Craigen WJ, Sweatt JD. Mitochondrial regulation of synaptic plasticity in the hippocampus. J Biol Chem. 2003 May 16; 278(20):17727-34. PMID: 12604600.
      Citations: 72     Fields:    Translation:AnimalsCells
    39. Faas GC, Adwanikar H, Gereau RW, Saggau P. Modulation of presynaptic calcium transients by metabotropic glutamate receptor activation: a differential role in acute depression of synaptic transmission and long-term depression. J Neurosci. 2002 Aug 15; 22(16):6885-90. PMID: 12177186; PMCID: PMC6757876.
      Citations: 45     Fields:    Translation:AnimalsCells
    40. Sinha SR, Saggau P. Imaging of 4-AP-induced, GABA(A)-dependent spontaneous synchronized activity mediated by the hippocampal interneuron network. J Neurophysiol. 2001 Jul; 86(1):381-91. PMID: 11431518.
      Citations: 7     Fields:    Translation:AnimalsCells
    41. Godbey WT, Barry MA, Saggau P, Wu KK, Mikos AG. Poly(ethylenimine)-mediated transfection: a new paradigm for gene delivery. J Biomed Mater Res. 2000 Sep 05; 51(3):321-8. PMID: 10880073.
      Citations: 62     Fields:    Translation:HumansAnimalsCells
    42. Xiong ZQ, Saggau P, Stringer JL. Activity-dependent intracellular acidification correlates with the duration of seizure activity. J Neurosci. 2000 Feb 15; 20(4):1290-6. PMID: 10662818; PMCID: PMC6772378.
      Citations: 49     Fields:    Translation:AnimalsCells
    43. Qian J, Saggau P. Activity-dependent modulation of K+ currents at presynaptic terminals of mammalian central synapses. J Physiol. 1999 Sep 01; 519 Pt 2:427-37. PMID: 10457060; PMCID: PMC2269500.
      Citations: 7     Fields:    Translation:AnimalsCells
    44. Sinha SR, Saggau P. Simultaneous optical recording of membrane potential and intracellular calcium from brain slices. Methods. 1999 Jun; 18(2):204-14, 175. PMID: 10356352.
      Citations: 6     Fields:    Translation:AnimalsCells
    45. Bullen A, Saggau P. High-speed, random-access fluorescence microscopy: II. Fast quantitative measurements with voltage-sensitive dyes. Biophys J. 1999 Apr; 76(4):2272-87. PMID: 10096922; PMCID: PMC1300200.
      Citations: 36     Fields:    Translation:AnimalsCells
    46. Saggau P, Gray R, Dani JA. Optical measurements of calcium signals in mammalian presynaptic terminals. Methods Enzymol. 1999; 294:3-19. PMID: 9916220.
      Citations: 1     Fields:    Translation:AnimalsCells
    47. Qian J, Saggau P. Modulation of transmitter release by action potential duration at the hippocampal CA3-CA1 synapse. J Neurophysiol. 1999 Jan; 81(1):288-98. PMID: 9914289.
      Citations: 24     Fields:    Translation:AnimalsCells
    48. Bullen A, Saggau P. Indicators and optical configuration for simultaneous high-resolution recording of membrane potential and intracellular calcium using laser scanning microscopy. Pflugers Arch. 1998 Oct; 436(5):788-96. PMID: 9716714.
      Citations: 7     Fields:    Translation:AnimalsCells
    49. Saggau P, Bullen A, Patel SS. Acousto-optic random-access laser scanning microscopy: fundamentals and applications to optical recording of neuronal activity. Cell Mol Biol (Noisy-le-grand). 1998 Jul; 44(5):827-46. PMID: 9764750.
      Citations: 2     Fields:    Translation:AnimalsCells
    50. Qian J, Colmers WF, Saggau P. Inhibition of synaptic transmission by neuropeptide Y in rat hippocampal area CA1: modulation of presynaptic Ca2+ entry. J Neurosci. 1997 Nov 01; 17(21):8169-77. PMID: 9334392; PMCID: PMC6573734.
      Citations: 65     Fields:    Translation:AnimalsCells
    51. Qian J, Saggau P. Presynaptic inhibition of synaptic transmission in the rat hippocampus by activation of muscarinic receptors: involvement of presynaptic calcium influx. Br J Pharmacol. 1997 Oct; 122(3):511-9. PMID: 9351508; PMCID: PMC1564959.
      Citations: 25     Fields:    Translation:AnimalsCells
    52. Bullen A, Patel SS, Saggau P. High-speed, random-access fluorescence microscopy: I. High-resolution optical recording with voltage-sensitive dyes and ion indicators. Biophys J. 1997 Jul; 73(1):477-91. PMID: 9199810; PMCID: PMC1180947.
      Citations: 28     Fields:    Translation:AnimalsCells
    53. Saggau P, Wu LG. Presynaptic inhibition of elicited neurotransmitter release. Trends Neurosci. 1997 May; 20(5):204-12. PMID: 9141196.
      Citations: 207     Fields:    Translation:HumansAnimalsCells
    54. Sinha SR, Wu LG, Saggau P. Presynaptic calcium dynamics and transmitter release evoked by single action potentials at mammalian central synapses. Biophys J. 1997 Feb; 72(2 Pt 1):637-51. PMID: 9017193; PMCID: PMC1185591.
      Citations: 33     Fields:    Translation:AnimalsCells
    55. Sinha SR, Patel SS, Saggau P. Simultaneous optical recording of evoked and spontaneous transients of membrane potential and intracellular calcium concentration with high spatio-temporal resolution. J Neurosci Methods. 1995 Aug; 60(1-2):49-60. PMID: 8544487.
      Citations: 4     Fields:    Translation:AnimalsCells
    56. Wu LG, Saggau P. GABAB receptor-mediated presynaptic inhibition in guinea-pig hippocampus is caused by reduction of presynaptic Ca2+ influx. J Physiol. 1995 Jun 15; 485 ( Pt 3):649-57. PMID: 7562607; PMCID: PMC1158034.
      Citations: 62     Fields:    Translation:AnimalsCells
    57. Wu LG, Saggau P. Block of multiple presynaptic calcium channel types by omega-conotoxin-MVIIC at hippocampal CA3 to CA1 synapses. J Neurophysiol. 1995 May; 73(5):1965-72. PMID: 7623094.
      Citations: 11     Fields:    Translation:AnimalsCells
    58. Wu LG, Saggau P. Pharmacological identification of two types of presynaptic voltage-dependent calcium channels at CA3-CA1 synapses of the hippocampus. J Neurosci. 1994 Sep; 14(9):5613-22. PMID: 8083757; PMCID: PMC6577093.
      Citations: 71     Fields:    Translation:AnimalsCells
    59. Wu LG, Saggau P. Adenosine inhibits evoked synaptic transmission primarily by reducing presynaptic calcium influx in area CA1 of hippocampus. Neuron. 1994 May; 12(5):1139-48. PMID: 8185949.
      Citations: 116     Fields:    Translation:Cells
    60. Colom LV, Saggau P. Spontaneous interictal-like activity originates in multiple areas of the CA2-CA3 region of hippocampal slices. J Neurophysiol. 1994 Apr; 71(4):1574-85. PMID: 8035236.
      Citations: 19     Fields:    Translation:AnimalsCells
    61. Wu LG, Saggau P. Presynaptic calcium is increased during normal synaptic transmission and paired-pulse facilitation, but not in long-term potentiation in area CA1 of hippocampus. J Neurosci. 1994 Feb; 14(2):645-54. PMID: 7905515; PMCID: PMC6576817.
      Citations: 100     Fields:    Translation:AnimalsCells
    62. Illert M, de la Motte S, Reeh P, Saggau P, Fritz N. Pattern of monosynaptic Ia connections in the cat forelimb. J Physiol. 1989 Dec; 419:321-51. PMID: 2533610; PMCID: PMC1190010.
      Citations: 23     Fields:    Translation:AnimalsCells
    63. Saggau P, Galvan M, ten Bruggencate G. Long-term potentiation in guinea pig hippocampal slices monitored by optical recording of neuronal activity. Neurosci Lett. 1986 Aug 15; 69(1):53-8. PMID: 3018636.
      Citations: 4     Fields:    Translation:AnimalsCells
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