"Scleroderma, Systemic" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A chronic multi-system disorder of CONNECTIVE TISSUE. It is characterized by SCLEROSIS in the SKIN, the LUNGS, the HEART, the GASTROINTESTINAL TRACT, the KIDNEYS, and the MUSCULOSKELETAL SYSTEM. Other important features include diseased small BLOOD VESSELS and AUTOANTIBODIES. The disorder is named for its most prominent feature (hard skin), and classified into subsets by the extent of skin thickening: LIMITED SCLERODERMA and DIFFUSE SCLERODERMA.
| Descriptor ID |
D012595
|
| MeSH Number(s) |
C17.300.799 C17.800.784
|
| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Scleroderma, Systemic".
Below are MeSH descriptors whose meaning is more specific than "Scleroderma, Systemic".
This graph shows the total number of publications written about "Scleroderma, Systemic" by people in this website by year, and whether "Scleroderma, Systemic" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1997 | 0 | 1 | 1 |
| 1998 | 1 | 0 | 1 |
| 2000 | 1 | 0 | 1 |
| 2004 | 0 | 1 | 1 |
| 2005 | 0 | 1 | 1 |
| 2008 | 2 | 1 | 3 |
| 2009 | 8 | 0 | 8 |
| 2010 | 5 | 0 | 5 |
| 2011 | 9 | 0 | 9 |
| 2012 | 3 | 0 | 3 |
| 2013 | 4 | 0 | 4 |
| 2014 | 6 | 1 | 7 |
| 2015 | 2 | 0 | 2 |
| 2016 | 5 | 0 | 5 |
| 2017 | 4 | 0 | 4 |
| 2018 | 4 | 1 | 5 |
| 2019 | 7 | 1 | 8 |
| 2020 | 3 | 0 | 3 |
| 2021 | 3 | 0 | 3 |
| 2023 | 6 | 0 | 6 |
| 2024 | 2 | 3 | 5 |
| 2025 | 7 | 0 | 7 |
| 2026 | 1 | 0 | 1 |
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Below are the most recent publications written about "Scleroderma, Systemic" by people in Profiles.
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The added value of cardiac MRI in paediatric rheumatologic disorders: a preliminary single-centre experience. Cardiol Young. 2026 Feb; 36(2):386-388.
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Assessment of Skin in Patients With Systemic Sclerosis Using High-Frequency Ultrasound and Shear Wave Elastography: A Comparative Study With Histology, Molecular, and Clinical Parameters. Arthritis Care Res (Hoboken). 2026 May; 78(5):582-590.
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International Investigation of the Gut-Lung Axis in Systemic Sclerosis-Interstitial Lung Disease. Arthritis Care Res (Hoboken). 2026 Mar; 78(3):352-361.
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Racial and ethnic associations with interstitial lung disease and healthcare utilization in patients with systemic sclerosis. Rheumatology (Oxford). 2025 Dec 01; 64(SI):SI131-SI139.
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A composite endpoint for systemic sclerosis-associated interstitial lung disease: association with mortality in two clinical trial cohorts. Respir Res. 2025 Nov 28; 26(1):337.
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Impact of quantitative radiological features of interstitial lung disease on immunomodulatory treatment response in three autoimmune interstitial lung disease cohorts. Thorax. 2025 07 15; 80(8):540-546.
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Integrative exome sequencing and machine learning identify MICB and interferon pathway genes as contributors to SSc risk. Ann Rheum Dis. 2025 Aug; 84(8):1363-1374.
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Assessment of skin fibrosis in a murine model of systemic sclerosis with multifunctional optical coherence tomography. J Biomed Opt. 2025 03; 30(3):036007.
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Exploring the complexity of systemic sclerosis etiology by trio whole genome sequencing. Hum Mol Genet. 2024 09 19; 33(19):1643-1647.
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PIK-III exerts anti-fibrotic effects in activated fibroblasts by regulating p38 activation. PLoS One. 2024; 19(9):e0306624.