"RNA-Binding Protein EWS" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A ubiquitous hnRNP protein that contains an RNA RECOGNITION MOTIF and C-terminal ranBP2-type zinc finger. It localizes to the CELL NUCLEUS and CYTOPLASM and is expressed as different isoforms in various tissues, interacting with CALMODULIN and TUMOR SUPPRESSOR PROTEIN P53 to negatively regulate cell growth. Translocations that result in the formation of fusion proteins containing parts of RNA-binding protein EWS are associated with EWING SARCOMA.
| Descriptor ID |
D034802
|
| MeSH Number(s) |
D12.644.360.650 D12.776.157.142.750 D12.776.157.725.813.750.900 D12.776.476.650 D12.776.624.664.700.913 D12.776.664.962.813.750.900
|
| Concept/Terms |
RNA-Binding Protein EWS- RNA-Binding Protein EWS
- EWS, RNA-Binding Protein
- RNA Binding Protein EWS
- EWSR1 Protein
- Protein, EWSR1
- Ewing Sarcoma Breakpoint Region 1 Protein
- EWS Proto-Oncogene Protein
- EWS Proto Oncogene Protein
- Proto-Oncogene Protein, EWS
- Ewing Sarcoma Breakpointregion 1 Protein
- EWS RNA Binding Protein 1
- EWS Protein
|
Below are MeSH descriptors whose meaning is more general than "RNA-Binding Protein EWS".
Below are MeSH descriptors whose meaning is more specific than "RNA-Binding Protein EWS".
This graph shows the total number of publications written about "RNA-Binding Protein EWS" by people in this website by year, and whether "RNA-Binding Protein EWS" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1996 | 0 | 1 | 1 |
| 1998 | 0 | 1 | 1 |
| 2001 | 0 | 2 | 2 |
| 2003 | 2 | 0 | 2 |
| 2008 | 0 | 4 | 4 |
| 2009 | 0 | 1 | 1 |
| 2010 | 0 | 1 | 1 |
| 2013 | 0 | 1 | 1 |
| 2014 | 0 | 1 | 1 |
| 2015 | 1 | 0 | 1 |
| 2017 | 1 | 1 | 2 |
| 2018 | 0 | 2 | 2 |
| 2019 | 0 | 1 | 1 |
| 2020 | 1 | 0 | 1 |
| 2022 | 0 | 1 | 1 |
| 2023 | 0 | 2 | 2 |
| 2025 | 2 | 1 | 3 |
To return to the timeline,
click here.
Below are the most recent publications written about "RNA-Binding Protein EWS" by people in Profiles.
-
Heterogeneous Folding Intermediates Govern the Conformational Pathway of the RNA Recognition Motif Domain of the Ewing Sarcoma Protein. Biomolecules. 2025 12 24; 16(1).
-
Synthetic ZFTA fusions pinpoint disordered protein domain acquisition as a mechanism of brain tumorigenesis. Nat Cell Biol. 2025 Sep; 27(9):1496-1509.
-
The O-glycosyltransferase C1GALT1 promotes EWSR1::FLI1 expression and is a therapeutic target for Ewing sarcoma. Nat Commun. 2025 Feb 02; 16(1):1267.
-
Targeted long-read sequencing of the Ewing sarcoma 6p25.1 susceptibility locus identifies germline-somatic interactions with EWSR1-FLI1 binding. Am J Hum Genet. 2023 03 02; 110(3):427-441.
-
Modeling Ewing Sarcoma Lung Metastasis. Curr Protoc. 2023 Feb; 3(2):e670.
-
EWSR1-PATZ1 Fusion Gene in Ependymoma: A Report of Two Adult Cases and Systematic Review of Literature. JCO Precis Oncol. 2022 12; 6:e2200312.
-
EWSR1-SMAD3 rearranged fibroblastic tumor: Case series and review. J Cutan Pathol. 2021 Feb; 48(2):255-262.
-
Imatinib revives the therapeutic potential of metformin on ewing sarcoma by attenuating tumor hypoxic response and inhibiting convergent signaling pathways. Cancer Lett. 2020 01 28; 469:195-206.
-
PAX7 expression in sarcomas bearing the EWSR1-NFATC2 translocation. Mod Pathol. 2019 01; 32(1):154-156.
-
Multimodality Treatment of Desmoplastic Small Round Cell Tumor: Chemotherapy and Complete Cytoreductive Surgery Improve Patient Survival. Clin Cancer Res. 2018 10 01; 24(19):4865-4873.