Mitogen-Activated Protein Kinases
"Mitogen-Activated Protein Kinases" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A superfamily of PROTEIN-SERINE-THREONINE KINASES that are activated by diverse stimuli via protein kinase cascades. They are the final components of the cascades, activated by phosphorylation by MITOGEN-ACTIVATED PROTEIN KINASE KINASES, which in turn are activated by mitogen-activated protein kinase kinase kinases (MAP KINASE KINASE KINASES).
| Descriptor ID |
D020928
|
| MeSH Number(s) |
D08.811.913.696.620.682.700.567 D12.644.360.450 D12.776.476.450
|
| Concept/Terms |
Mitogen-Activated Protein Kinases- Mitogen-Activated Protein Kinases
- Kinases, Mitogen-Activated Protein
- Mitogen Activated Protein Kinases
- Protein Kinases, Mitogen-Activated
|
Below are MeSH descriptors whose meaning is more general than "Mitogen-Activated Protein Kinases".
Below are MeSH descriptors whose meaning is more specific than "Mitogen-Activated Protein Kinases".
This graph shows the total number of publications written about "Mitogen-Activated Protein Kinases" by people in this website by year, and whether "Mitogen-Activated Protein Kinases" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1998 | 1 | 0 | 1 |
| 1999 | 8 | 0 | 8 |
| 2000 | 5 | 6 | 11 |
| 2001 | 6 | 6 | 12 |
| 2002 | 6 | 9 | 15 |
| 2003 | 8 | 8 | 16 |
| 2004 | 6 | 6 | 12 |
| 2005 | 2 | 2 | 4 |
| 2006 | 3 | 7 | 10 |
| 2007 | 1 | 4 | 5 |
| 2008 | 1 | 6 | 7 |
| 2009 | 1 | 1 | 2 |
| 2010 | 1 | 1 | 2 |
| 2011 | 4 | 3 | 7 |
| 2012 | 2 | 2 | 4 |
| 2013 | 4 | 1 | 5 |
| 2014 | 0 | 5 | 5 |
| 2015 | 1 | 0 | 1 |
| 2016 | 2 | 2 | 4 |
| 2017 | 0 | 1 | 1 |
| 2018 | 0 | 3 | 3 |
| 2019 | 1 | 0 | 1 |
| 2020 | 0 | 1 | 1 |
| 2021 | 0 | 1 | 1 |
| 2022 | 2 | 6 | 8 |
| 2023 | 1 | 1 | 2 |
| 2024 | 1 | 1 | 2 |
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Below are the most recent publications written about "Mitogen-Activated Protein Kinases" by people in Profiles.
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Phase II Study of Ulixertinib in Children and Young Adults With Tumors Harboring Activating Mitogen-Activated Protein Kinase Pathway Alterations: APEC1621J of the National Cancer Institute-Children's Oncology Group Pediatric MATCH Trial. JCO Precis Oncol. 2024 Jun; 8:e2400103.
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Leishmania donovani mitogen-activated protein kinases as a host-parasite interaction interface. Cytokine. 2024 07; 179:156627.
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Convergent MAPK pathway alterations mediate acquired?resistance to FGFR inhibitors in FGFR2 fusion-positive cholangiocarcinoma. J Hepatol. 2024 02; 80(2):322-334.
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A novel small molecule inhibitor of p38? MAP kinase augments cardiomyocyte cell cycle entry in response to direct cell cycle stimulation. Br J Pharmacol. 2023 12; 180(24):3271-3289.
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Cooperative activation of PDK1 and AKT by MAPK4 enhances cancer growth and resistance to therapy. PLoS Biol. 2023 08; 21(8):e3002227.
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The Next Generation of KRAS Targeting: Reasons for Excitement and Concern. Mol Cancer Ther. 2022 11 03; 21(11):1645-1651.
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Paediatric Strategy Forum for medicinal product development in mitogen-activated protein kinase pathway inhibitors: ACCELERATE in collaboration with the European Medicines Agency with participation of the Food and Drug Administration. Eur J Cancer. 2022 12; 177:120-142.
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Prospective, Multi-Institutional, Real-Time Next-Generation Sequencing of Pancreatic Cyst Fluid Reveals Diverse Genomic Alterations That Improve the Clinical Management of Pancreatic Cysts. Gastroenterology. 2023 01; 164(1):117-133.e7.
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Histiocytic Disorders of Childhood. Pediatr Rev. 2022 Oct 01; 43(10):561-571.
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Environmental oxygen affects ex vivo growth and proliferation of mesenchymal progenitors by modulating mitogen-activated protein kinase and mammalian target of rapamycin signaling. Cytotherapy. 2022 12; 24(12):1201-1210.