"Protein Kinase C" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An serine-threonine protein kinase that requires the presence of physiological concentrations of CALCIUM and membrane PHOSPHOLIPIDS. The additional presence of DIACYLGLYCEROLS markedly increases its sensitivity to both calcium and phospholipids. The sensitivity of the enzyme can also be increased by PHORBOL ESTERS and it is believed that protein kinase C is the receptor protein of tumor-promoting phorbol esters.
| Descriptor ID |
D011493
|
| MeSH Number(s) |
D08.811.913.696.620.682.700.725
|
| Concept/Terms |
Protein Kinase C- Protein Kinase C
- Calcium-Activated Phospholipid-Dependent Kinase
- Calcium Activated Phospholipid Dependent Kinase
- Phospholipid-Dependent Kinase, Calcium-Activated
- PKC Serine-Threonine Kinase
- PKC Serine Threonine Kinase
- Serine-Threonine Kinase, PKC
- Calcium Phospholipid-Dependent Protein Kinase
- Calcium Phospholipid Dependent Protein Kinase
- Phospholipid-Sensitive Calcium-Dependent Protein Kinase
- Phospholipid Sensitive Calcium Dependent Protein Kinase
|
Below are MeSH descriptors whose meaning is more general than "Protein Kinase C".
Below are MeSH descriptors whose meaning is more specific than "Protein Kinase C".
This graph shows the total number of publications written about "Protein Kinase C" by people in this website by year, and whether "Protein Kinase C" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1998 | 4 | 0 | 4 |
| 1999 | 2 | 2 | 4 |
| 2000 | 2 | 0 | 2 |
| 2001 | 1 | 5 | 6 |
| 2002 | 4 | 1 | 5 |
| 2003 | 1 | 4 | 5 |
| 2004 | 1 | 3 | 4 |
| 2005 | 4 | 4 | 8 |
| 2006 | 2 | 2 | 4 |
| 2007 | 0 | 2 | 2 |
| 2008 | 3 | 2 | 5 |
| 2009 | 2 | 6 | 8 |
| 2010 | 2 | 0 | 2 |
| 2011 | 2 | 3 | 5 |
| 2012 | 1 | 1 | 2 |
| 2013 | 2 | 3 | 5 |
| 2014 | 2 | 2 | 4 |
| 2016 | 1 | 0 | 1 |
| 2017 | 2 | 0 | 2 |
| 2018 | 1 | 1 | 2 |
| 2019 | 0 | 4 | 4 |
| 2020 | 0 | 2 | 2 |
| 2021 | 1 | 1 | 2 |
| 2022 | 0 | 1 | 1 |
| 2023 | 0 | 1 | 1 |
| 2024 | 0 | 1 | 1 |
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Below are the most recent publications written about "Protein Kinase C" by people in Profiles.
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PKC-mediated phosphorylation governs the stability and function of CELF1 as a driver of EMT in breast epithelial cells. J Biol Chem. 2024 11; 300(11):107826.
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Activation of Munc13-1 by Diacylglycerol (DAG)-Lactones. Biochemistry. 2023 09 19; 62(18):2717-2726.
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Depletion of the apical endosome in response to viruses and bacterial toxins provides cell-autonomous host defense at mucosal surfaces. Cell Host Microbe. 2022 02 09; 30(2):216-231.e5.
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Voluntary oral methamphetamine increases memory deficits and contextual sensitization during abstinence associated with decreased PKM? and increased ?OR in the hippocampus of female mice. J Psychopharmacol. 2021 Oct; 35(10):1240-1252.
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TLR2 dimer-specific ligands selectively activate protein kinase C isoforms in Leishmania infection. Immunology. 2021 10; 164(2):318-331.
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Legumain Induces Oral Cancer Pain by Biased Agonism of Protease-Activated Receptor-2. J Neurosci. 2021 01 06; 41(1):193-210.
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Inhibitors of metalloprotease, ?-sectretase, protein kinase C and Rho kinase inhibit wild-type adenoviral replication. PLoS One. 2020; 15(7):e0236175.
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Naturally-derived diterpenoid sphaeropsidin C as an activator of Nrf2/ARE pathway and its potential capability of relieving intracellular oxidative stress in human lung epithelial cells. Biomed Pharmacother. 2020 Jan; 121:109669.
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Proteomics in gastroparesis: unique and overlapping protein signatures in diabetic and idiopathic gastroparesis. Am J Physiol Gastrointest Liver Physiol. 2019 11 01; 317(5):G716-G726.
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Absence of gravin-mediated signaling inhibits development of high-fat diet-induced hyperlipidemia and atherosclerosis. Am J Physiol Heart Circ Physiol. 2019 10 01; 317(4):H793-H810.