"Protein Kinase C" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An serine-threonine protein kinase that requires the presence of physiological concentrations of CALCIUM and membrane PHOSPHOLIPIDS. The additional presence of DIACYLGLYCEROLS markedly increases its sensitivity to both calcium and phospholipids. The sensitivity of the enzyme can also be increased by PHORBOL ESTERS and it is believed that protein kinase C is the receptor protein of tumor-promoting phorbol esters.
| Descriptor ID |
D011493
|
| MeSH Number(s) |
D08.811.913.696.620.682.700.725
|
| Concept/Terms |
Protein Kinase C- Protein Kinase C
- Calcium-Activated Phospholipid-Dependent Kinase
- Calcium Activated Phospholipid Dependent Kinase
- Phospholipid-Dependent Kinase, Calcium-Activated
- PKC Serine-Threonine Kinase
- PKC Serine Threonine Kinase
- Serine-Threonine Kinase, PKC
- Calcium Phospholipid-Dependent Protein Kinase
- Calcium Phospholipid Dependent Protein Kinase
- Phospholipid-Sensitive Calcium-Dependent Protein Kinase
- Phospholipid Sensitive Calcium Dependent Protein Kinase
|
Below are MeSH descriptors whose meaning is more general than "Protein Kinase C".
Below are MeSH descriptors whose meaning is more specific than "Protein Kinase C".
This graph shows the total number of publications written about "Protein Kinase C" by people in this website by year, and whether "Protein Kinase C" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1994 | 1 | 4 | 5 |
| 1995 | 3 | 4 | 7 |
| 1996 | 2 | 1 | 3 |
| 1997 | 3 | 6 | 9 |
| 1998 | 6 | 4 | 10 |
| 1999 | 3 | 3 | 6 |
| 2000 | 7 | 1 | 8 |
| 2001 | 4 | 12 | 16 |
| 2002 | 9 | 8 | 17 |
| 2003 | 5 | 7 | 12 |
| 2004 | 3 | 10 | 13 |
| 2005 | 10 | 15 | 25 |
| 2006 | 7 | 9 | 16 |
| 2007 | 6 | 8 | 14 |
| 2008 | 7 | 8 | 15 |
| 2009 | 4 | 11 | 15 |
| 2010 | 5 | 1 | 6 |
| 2011 | 4 | 7 | 11 |
| 2012 | 3 | 2 | 5 |
| 2013 | 2 | 3 | 5 |
| 2014 | 2 | 4 | 6 |
| 2015 | 1 | 0 | 1 |
| 2016 | 3 | 1 | 4 |
| 2017 | 6 | 1 | 7 |
| 2018 | 2 | 1 | 3 |
| 2019 | 1 | 6 | 7 |
| 2020 | 0 | 2 | 2 |
| 2021 | 2 | 1 | 3 |
| 2022 | 0 | 3 | 3 |
| 2023 | 0 | 1 | 1 |
| 2024 | 0 | 1 | 1 |
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Below are the most recent publications written about "Protein Kinase C" by people in Profiles.
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PKC-mediated phosphorylation governs the stability and function of CELF1 as a driver of EMT in breast epithelial cells. J Biol Chem. 2024 Nov; 300(11):107826.
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Activation of Munc13-1 by Diacylglycerol (DAG)-Lactones. Biochemistry. 2023 09 19; 62(18):2717-2726.
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Brief Opioid Exposure Paradoxically Augments Primary Afferent Input to Spinal Excitatory Neurons via a2d-1-Dependent Presynaptic NMDA Receptors. J Neurosci. 2022 12 14; 42(50):9315-9329.
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Muscarinic receptor activation in colon cancer selectively augments pro-proliferative microRNA-21, microRNA-221 and microRNA-222 expression. PLoS One. 2022; 17(6):e0269618.
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Depletion of the apical endosome in response to viruses and bacterial toxins provides cell-autonomous host defense at mucosal surfaces. Cell Host Microbe. 2022 02 09; 30(2):216-231.e5.
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Voluntary oral methamphetamine increases memory deficits and contextual sensitization during abstinence associated with decreased PKM? and increased ?OR in the hippocampus of female mice. J Psychopharmacol. 2021 Oct; 35(10):1240-1252.
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Protein Kinase C-Mediated Phosphorylation and a2d-1 Interdependently Regulate NMDA Receptor Trafficking and Activity. J Neurosci. 2021 07 28; 41(30):6415-6429.
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TLR2 dimer-specific ligands selectively activate protein kinase C isoforms in Leishmania infection. Immunology. 2021 10; 164(2):318-331.
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Inhibitors of metalloprotease, ?-sectretase, protein kinase C and Rho kinase inhibit wild-type adenoviral replication. PLoS One. 2020; 15(7):e0236175.
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DGK? Knock-Out Mice Show Impairments in Cerebellar Motor Coordination, LTD, and the Dendritic Development of Purkinje Cells through the Activation of PKC?. eNeuro. 2020 Mar/Apr; 7(2).