"Protein Kinase C-delta" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A ubiquitously expressed protein kinase that is involved in a variety of cellular SIGNAL PATHWAYS. Its activity is regulated by a variety of signaling protein tyrosine kinase.
| Descriptor ID |
D051745
|
| MeSH Number(s) |
D08.811.913.696.620.682.700.725.400
|
| Concept/Terms |
Protein Kinase C-delta- Protein Kinase C-delta
- Kinase C-delta, Protein
- Protein Kinase C delta
- PKC-delta Serine-Threonine Kinase
- PKC delta Serine Threonine Kinase
- Serine-Threonine Kinase, PKC-delta
|
Below are MeSH descriptors whose meaning is more general than "Protein Kinase C-delta".
Below are MeSH descriptors whose meaning is more specific than "Protein Kinase C-delta".
This graph shows the total number of publications written about "Protein Kinase C-delta" by people in this website by year, and whether "Protein Kinase C-delta" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2003 | 0 | 1 | 1 |
| 2004 | 0 | 1 | 1 |
| 2005 | 0 | 1 | 1 |
| 2006 | 1 | 0 | 1 |
| 2009 | 2 | 0 | 2 |
| 2010 | 1 | 0 | 1 |
| 2011 | 1 | 0 | 1 |
| 2012 | 1 | 0 | 1 |
| 2013 | 0 | 1 | 1 |
| 2014 | 2 | 0 | 2 |
| 2015 | 0 | 1 | 1 |
| 2022 | 0 | 1 | 1 |
To return to the timeline,
click here.
Below are the most recent publications written about "Protein Kinase C-delta" by people in Profiles.
-
CGRP-dependent sensitization of PKC-d positive neurons in central amygdala mediates chronic migraine. J Headache Pain. 2022 Dec 12; 23(1):157.
-
PKCd-mediated SGLT1 upregulation confers the acquired resistance of NSCLC to EGFR TKIs. Oncogene. 2021 Jul; 40(29):4796-4808.
-
Targeting PKCd as a Therapeutic Strategy against Heterogeneous Mechanisms of EGFR Inhibitor Resistance in EGFR-Mutant Lung Cancer. Cancer Cell. 2018 12 10; 34(6):954-969.e4.
-
Protein kinase Cd upregulation in microglia drives neuroinflammatory responses and dopaminergic neurodegeneration in experimental models of Parkinson's disease. Neurobiol Dis. 2016 09; 93:96-114.
-
Inactivation of PNKP by mutant ATXN3 triggers apoptosis by activating the DNA damage-response pathway in SCA3. PLoS Genet. 2015 Jan; 11(1):e1004834.
-
Prenatal testosterone exposure induces hypertension in adult females via androgen receptor-dependent protein kinase Cd-mediated mechanism. Hypertension. 2015 Mar; 65(3):683-690.
-
Histone hyperacetylation up-regulates protein kinase Cd in dopaminergic neurons to induce cell death: relevance to epigenetic mechanisms of neurodegeneration in Parkinson disease. J Biol Chem. 2014 Dec 12; 289(50):34743-67.
-
API5 confers tumoral immune escape through FGF2-dependent cell survival pathway. Cancer Res. 2014 Jul 01; 74(13):3556-66.
-
Protein kinase C delta modulates endothelial nitric oxide synthase after cardiac arrest. J Cereb Blood Flow Metab. 2014 Apr; 34(4):613-20.
-
Nicotine potentiates proatherogenic effects of oxLDL by stimulating and upregulating macrophage CD36 signaling. Am J Physiol Heart Circ Physiol. 2013 Aug 15; 305(4):H563-74.