"Protein Kinase C-theta" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A calcium-independent, phospholipid- and diacylglycerol-dependent, protein kinase C subtype that contains an N-terminal C2 DOMAIN and two diacylglycerol-binding ZINC FINGERS. It is expressed primarily by T-LYMPHOCYTES and localizes to IMMUNOLOGICAL SYNAPSES where it regulates downstream signaling for the activation, proliferation, and survival of mature T-cells. It plays a critical role in allergic, autoimmune, and alloimmune responses of TH2 CELLS and TH17 CELLS.
| Descriptor ID |
D000074121
|
| MeSH Number(s) |
D08.811.913.696.620.682.700.725.075
|
| Concept/Terms |
Protein Kinase C-theta- Protein Kinase C-theta
- Protein Kinase C, theta
- PRKCQ
- Protein Kinase C theta
- PKC-theta
- PKC theta
|
Below are MeSH descriptors whose meaning is more general than "Protein Kinase C-theta".
Below are MeSH descriptors whose meaning is more specific than "Protein Kinase C-theta".
This graph shows the total number of publications written about "Protein Kinase C-theta" by people in this website by year, and whether "Protein Kinase C-theta" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2013 | 0 | 1 | 1 |
| 2018 | 1 | 0 | 1 |
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Below are the most recent publications written about "Protein Kinase C-theta" by people in Profiles.
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GLK-IKK? signaling induces dimerization and translocation of the AhR-ROR?t complex in IL-17A induction and autoimmune disease. Sci Adv. 2018 09; 4(9):eaat5401.
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Structural determinants of phorbol ester binding activity of the C1a and C1b domains of protein kinase C theta. Biochim Biophys Acta Biomembr. 2018 May; 1860(5):1046-1056.
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Identification of the activator-binding residues in the second cysteine-rich regulatory domain of protein kinase C? (PKC?). Biochem J. 2013 Apr 01; 451(1):33-44.
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Disturbed-flow-mediated vascular reactive oxygen species induce endothelial dysfunction. Circ J. 2011; 75(12):2722-30.
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The kinase GLK controls autoimmunity and NF-?B signaling by activating the kinase PKC-? in T cells. Nat Immunol. 2011 Oct 09; 12(11):1113-8.
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Differential requirement of PKC-theta in the development and function of natural regulatory T cells. Mol Immunol. 2008 Dec; 46(2):213-24.
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Continuous fat oxidation in acetyl-CoA carboxylase 2 knockout mice increases total energy expenditure, reduces fat mass, and improves insulin sensitivity. Proc Natl Acad Sci U S A. 2007 Oct 16; 104(42):16480-5.
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Selective function of PKC-theta in T cells. Cell Mol Immunol. 2006 Aug; 3(4):263-70.
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Protein kinase C-theta-mediated signals enhance CD4+ T cell survival by up-regulating Bcl-xL. J Immunol. 2006 Jun 01; 176(11):6709-16.
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CD3/CD28 costimulation-induced NF-kappaB activation is mediated by recruitment of protein kinase C-theta, Bcl10, and IkappaB kinase beta to the immunological synapse through CARMA1. Mol Cell Biol. 2004 Jan; 24(1):164-71.