"Phorbol Esters" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Tumor-promoting compounds obtained from CROTON OIL (Croton tiglium). Some of these are used in cell biological experiments as activators of protein kinase C.
| Descriptor ID |
D010703
|
| MeSH Number(s) |
D02.455.849.291.500.510
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "Phorbol Esters".
Below are MeSH descriptors whose meaning is more specific than "Phorbol Esters".
This graph shows the total number of publications written about "Phorbol Esters" by people in this website by year, and whether "Phorbol Esters" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1994 | 1 | 2 | 3 |
| 1999 | 0 | 2 | 2 |
| 2003 | 1 | 0 | 1 |
| 2005 | 0 | 2 | 2 |
| 2006 | 1 | 1 | 2 |
| 2013 | 0 | 1 | 1 |
| 2014 | 1 | 1 | 2 |
| 2016 | 0 | 1 | 1 |
| 2017 | 0 | 1 | 1 |
| 2018 | 1 | 0 | 1 |
| 2019 | 0 | 2 | 2 |
| 2020 | 0 | 1 | 1 |
| 2021 | 2 | 1 | 3 |
| 2023 | 1 | 0 | 1 |
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Below are the most recent publications written about "Phorbol Esters" by people in Profiles.
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Comparison of the ligand binding site of C1 domains: a molecular dynamics simulation study of the C1 domain-phorbol 13-acetate-membrane system. J Biomol Struct Dyn. 2023; 41(21):11796-11809.
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Molecular dynamics simulation studies on binding of activator and inhibitor to Munc13-1 C1 in the presence of membrane. J Biomol Struct Dyn. 2022; 40(24):14160-14175.
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Megakaryoblastic leukemia: a study on novel role of clinically significant long non-coding RNA signatures in megakaryocyte development during treatment with phorbol ester. Cancer Immunol Immunother. 2021 Dec; 70(12):3477-3488.
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Probing the Diacylglycerol Binding Site of Presynaptic Munc13-1. Biochemistry. 2021 Apr 27; 60(16):1286-1298.
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Effect of ethanol on Munc13-1 C1 in Membrane: A Molecular Dynamics Simulation Study. Alcohol Clin Exp Res. 2020 07; 44(7):1344-1355.
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Munc13 Is a Molecular Target of Bryostatin 1. Biochemistry. 2019 07 09; 58(27):3016-3030.
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The expression and function of TRPV4 channels in primate retinal ganglion cells and bipolar cells. Cell Death Dis. 2019 05 07; 10(5):364.
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Structural determinants of phorbol ester binding activity of the C1a and C1b domains of protein kinase C theta. Biochim Biophys Acta Biomembr. 2018 May; 1860(5):1046-1056.
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Resveratrol inhibits phorbol ester-induced membrane translocation of presynaptic Munc13-1. Biochim Biophys Acta Gen Subj. 2017 Nov; 1861(11 Pt A):2640-2651.
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Curcumin Inhibits Protein Kinase Ca Activity by Binding to Its C1 Domain. Biochemistry. 2016 Nov 15; 55(45):6327-6336.