"Phorbol 12,13-Dibutyrate" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A phorbol ester found in CROTON OIL which, in addition to being a potent skin tumor promoter, is also an effective activator of calcium-activated, phospholipid-dependent protein kinase (protein kinase C). Due to its activation of this enzyme, phorbol 12,13-dibutyrate profoundly affects many different biological systems.
| Descriptor ID |
D015240
|
| MeSH Number(s) |
D02.455.849.291.500.510.700
|
| Concept/Terms |
Phorbol 12,13-Dibutyrate- Phorbol 12,13-Dibutyrate
- 12,13-Dibutyrate, Phorbol
- Phorbol-12,13-Dibutyrate
- Phorbol 12,13 Dibutyrate
|
Below are MeSH descriptors whose meaning is more general than "Phorbol 12,13-Dibutyrate".
Below are MeSH descriptors whose meaning is more specific than "Phorbol 12,13-Dibutyrate".
This graph shows the total number of publications written about "Phorbol 12,13-Dibutyrate" by people in this website by year, and whether "Phorbol 12,13-Dibutyrate" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1995 | 0 | 1 | 1 |
| 1998 | 0 | 1 | 1 |
| 2001 | 0 | 2 | 2 |
| 2005 | 0 | 2 | 2 |
| 2010 | 0 | 1 | 1 |
| 2018 | 0 | 1 | 1 |
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Below are the most recent publications written about "Phorbol 12,13-Dibutyrate" by people in Profiles.
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Critical Role of Trp-588 of Presynaptic Munc13-1 for Ligand Binding and Membrane Translocation. Biochemistry. 2018 02 06; 57(5):732-741.
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Raf-1 kinase regulates smooth muscle contraction in the rat mesenteric arteries. J Vasc Res. 2010; 47(5):384-98.
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Effect of fluvastatin on apoptosis in human CD4+ T cells. Cell Immunol. 2005 Jun; 235(2):136-44.
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Mechanism by which peripheral galanin increases acute inflammatory pain. Brain Res. 2005 Sep 21; 1056(2):113-7.
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Insulin increases the turnover rate of Na+-K+-ATPase in human fibroblasts. Am J Physiol Cell Physiol. 2001 Apr; 280(4):C912-9.
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Hyperphosphorylation of Na-pump contributes to defective renal dopamine response in old rats. J Am Soc Nephrol. 2001 Feb; 12(2):226-232.
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Loss of inositol 1,4,5-trisphosphate receptor sites and decreased PKC levels correlate with staging of Alzheimer's disease neurofibrillary pathology. Brain Res. 1998 Jun 15; 796(1-2):209-21.
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Effects of modulators of protein kinases on taxol-induced apoptosis of human leukemic cells possessing disparate levels of p26BCL-2 protein. Clin Cancer Res. 1995 Nov; 1(11):1399-406.
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The in vivo effects of rhIL-1 alpha therapy on human monocyte activity. J Leukoc Biol. 1993 Oct; 54(4):314-21.
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Secretory processing of the Alzheimer amyloid beta/A4 protein precursor is increased by protein phosphorylation. Biochem Biophys Res Commun. 1992 Sep 30; 187(3):1285-90.