WNK Lysine-Deficient Protein Kinase 1
"WNK Lysine-Deficient Protein Kinase 1" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A serine-threonine kinase which plays an important role in the regulation of electrolyte homeostasis, cell signaling, survival, and proliferation. It functions as an activator and inhibitor of sodium-coupled chloride co-transporters and as an inhibitor of potassium-coupled chloride co-transporters. Mutations in the WNK1 gene are associated with type 2C PSEUDOHYPOALDOSTERONISM and type 2A HEREDITARY SENSORY AND AUTONOMIC NEUROPATHIES.
| Descriptor ID |
D000076204
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| MeSH Number(s) |
D08.811.913.696.620.682.700.982 D12.644.360.975 D12.776.476.944 D23.050.301.500.600.962 D23.050.705.552.600.925
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "WNK Lysine-Deficient Protein Kinase 1".
Below are MeSH descriptors whose meaning is more specific than "WNK Lysine-Deficient Protein Kinase 1".
This graph shows the total number of publications written about "WNK Lysine-Deficient Protein Kinase 1" by people in this website by year, and whether "WNK Lysine-Deficient Protein Kinase 1" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2003 | 0 | 1 | 1 |
| 2005 | 0 | 1 | 1 |
| 2014 | 0 | 1 | 1 |
| 2017 | 1 | 0 | 1 |
| 2020 | 1 | 0 | 1 |
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Below are the most recent publications written about "WNK Lysine-Deficient Protein Kinase 1" by people in Profiles.
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WNK1 regulates uterine homeostasis and its ability to support pregnancy. JCI Insight. 2020 11 19; 5(22).
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WNK lysine deficient protein kinase 1 regulates human endometrial stromal cell decidualization, proliferation, and migration in part through mitogen-activated protein kinase 7. Biol Reprod. 2017 Sep 01; 97(3):400-412.
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The epidermal growth factor receptor critically regulates endometrial function during early pregnancy. PLoS Genet. 2014 Jun; 10(6):e1004451.
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WNK1 kinase polymorphism and blood pressure response to a thiazide diuretic. Hypertension. 2005 Oct; 46(4):758-65.
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Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Proc Natl Acad Sci U S A. 2003 Nov 25; 100(24):14109-14.