Activating Transcription Factor 6
"Activating Transcription Factor 6" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
One of the BASIC-LEUCINE ZIPPER TRANSCRIPTION FACTORS that is synthesized as a membrane-bound protein in the ENDOPLASMIC RETICULUM. In response to endoplasmic reticulum stress it translocates to the GOLGI APPARATUS. It is activated by PROTEASES and then moves to the CELL NUCLEUS to regulate GENETIC TRANSCRIPTION of GENES involved in the unfolded protein response.
| Descriptor ID |
D051702
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| MeSH Number(s) |
D12.644.360.011 D12.776.260.108.061.968 D12.776.476.011 D12.776.930.127.061.968
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "Activating Transcription Factor 6".
Below are MeSH descriptors whose meaning is more specific than "Activating Transcription Factor 6".
This graph shows the total number of publications written about "Activating Transcription Factor 6" by people in this website by year, and whether "Activating Transcription Factor 6" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2000 | 0 | 1 | 1 |
| 2008 | 1 | 0 | 1 |
| 2015 | 1 | 1 | 2 |
| 2018 | 1 | 0 | 1 |
| 2019 | 0 | 2 | 2 |
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Below are the most recent publications written about "Activating Transcription Factor 6" by people in Profiles.
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Pluronic block copolymers enhance the anti-myeloma activity of proteasome inhibitors. J Control Release. 2019 07 28; 306:149-164.
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MAGI1 as a link between endothelial activation and ER stress drives atherosclerosis. JCI Insight. 2019 04 04; 4(7).
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Exercise Mitigates Alcohol Induced Endoplasmic Reticulum Stress Mediated Cognitive Impairment through ATF6-Herp Signaling. Sci Rep. 2018 03 26; 8(1):5158.
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Dissection of Thrombospondin-4 Domains Involved in Intracellular Adaptive Endoplasmic Reticulum Stress-Responsive Signaling. Mol Cell Biol. 2016 Jan 01; 36(1):2-12.
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Mutation of ATF6 causes autosomal recessive achromatopsia. Hum Genet. 2015 Sep; 134(9):941-50.
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ATF6 Is Mutated in Early Onset Photoreceptor Degeneration With Macular Involvement. Invest Ophthalmol Vis Sci. 2015 Jun; 56(6):3889-95.
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Nelfinavir inhibits regulated intramembrane proteolysis of sterol regulatory element binding protein-1 and activating transcription factor 6 in castration-resistant prostate cancer. FEBS J. 2012 Jul; 279(13):2399-411.
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Nelfinavir induces liposarcoma apoptosis through inhibition of regulated intramembrane proteolysis of SREBP-1 and ATF6. Clin Cancer Res. 2011 Apr 01; 17(7):1796-806.
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Unfolded protein response suppresses CEBPA by induction of calreticulin in acute myeloid leukaemia. J Cell Mol Med. 2010 Jun; 14(6B):1509-19.
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CBF/NF-Y controls endoplasmic reticulum stress induced transcription through recruitment of both ATF6(N) and TBP. J Cell Biochem. 2008 Aug 01; 104(5):1708-23.