Immunoglobulin Class Switching
"Immunoglobulin Class Switching" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Gene rearrangement of the B-lymphocyte which results in a substitution in the type of heavy-chain constant region that is expressed. This allows the effector response to change while the antigen binding specificity (variable region) remains the same. The majority of class switching occurs by a DNA recombination event but it also can take place at the level of RNA processing.
| Descriptor ID |
D017578
|
| MeSH Number(s) |
G05.344.401.501.450 G12.500.274.501.450
|
| Concept/Terms |
Immunoglobulin Class Switching- Immunoglobulin Class Switching
- Class Switching, Immunoglobulin
- Class Switchings, Immunoglobulin
- Immunoglobulin Class Switchings
- Switching, Immunoglobulin Class
- Switchings, Immunoglobulin Class
- Class Switching
- Class Switchings
- Switching, Class
- Switchings, Class
- Isotype Switching
- Isotype Switchings
- Switching, Isotype
- Switchings, Isotype
|
Below are MeSH descriptors whose meaning is more general than "Immunoglobulin Class Switching".
Below are MeSH descriptors whose meaning is more specific than "Immunoglobulin Class Switching".
This graph shows the total number of publications written about "Immunoglobulin Class Switching" by people in this website by year, and whether "Immunoglobulin Class Switching" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1995 | 0 | 1 | 1 |
| 2004 | 1 | 0 | 1 |
| 2005 | 0 | 2 | 2 |
| 2007 | 1 | 1 | 2 |
| 2008 | 0 | 1 | 1 |
| 2009 | 0 | 1 | 1 |
| 2017 | 1 | 1 | 2 |
| 2020 | 1 | 0 | 1 |
| 2021 | 0 | 1 | 1 |
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Below are the most recent publications written about "Immunoglobulin Class Switching" by people in Profiles.
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Durable SARS-CoV-2 B cell immunity after mild or severe disease. J Clin Invest. 2021 04 01; 131(7).
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Dangerous Liaisons: Gammaherpesvirus Subversion of the Immunoglobulin Repertoire. Viruses. 2020 07 23; 12(8).
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Persistent hypogammaglobulinemia due to immunoglobulin class switch impairment by peri-transplant rituximab therapy. Int J Hematol. 2020 Sep; 112(3):422-426.
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Phosphorylation promotes activation-induced cytidine deaminase activity at the Myc oncogene. J Exp Med. 2017 Dec 04; 214(12):3543-3552.
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Analysis of DNA polymerase ? function in meiotic recombination, immunoglobulin class-switching, and DNA damage tolerance. PLoS Genet. 2017 Jun; 13(6):e1006818.
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Smith-Magenis Syndrome Patients Often Display Antibody Deficiency but Not Other Immune Pathologies. J Allergy Clin Immunol Pract. 2017 Sep - Oct; 5(5):1344-1350.e3.
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RASGRP1 deficiency causes immunodeficiency with impaired cytoskeletal dynamics. Nat Immunol. 2016 Dec; 17(12):1352-1360.
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CCAAT/enhancer-binding protein a negatively regulates IFN-? expression in T cells. J Immunol. 2014 Dec 15; 193(12):6152-60.
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An inherited immunoglobulin class-switch recombination deficiency associated with a defect in the INO80 chromatin remodeling complex. J Allergy Clin Immunol. 2015 Apr; 135(4):998-1007.e6.
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Mechanism of suppression of chromosomal instability by DNA polymerase POLQ. PLoS Genet. 2014 Oct; 10(10):e1004654.