3',5'-Cyclic-AMP Phosphodiesterases

"3',5'-Cyclic-AMP Phosphodiesterases" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

Enzymes that catalyze the hydrolysis of CYCLIC AMP to form adenosine 5'-phosphate. The enzymes are widely distributed in animal tissue and control the level of intracellular cyclic AMP. Many specific enzymes classified under this heading demonstrate additional spcificity for 3',5'-cyclic IMP and CYCLIC GMP.

Descriptor ID	D015105
MeSH Number(s)	D08.811.277.352.640.150 D12.644.360.008 D12.776.476.008
Concept/Terms	3',5'-Cyclic-AMP Phosphodiesterases 3',5'-Cyclic-AMP Phosphodiesterases 3',5' Cyclic AMP Phosphodiesterases Phosphodiesterases, 3',5'-Cyclic-AMP 3',5'-Cyclic AMP 5'-Nucleotidohydrolase 3',5' Cyclic AMP 5' Nucleotidohydrolase 5'-Nucleotidohydrolase, 3',5'-Cyclic AMP AMP 5'-Nucleotidohydrolase, 3',5'-Cyclic 3',5' Cyclic AMP Phosphodiesterase 3',5'-Cyclic AMP Phosphodiesterase AMP Phosphodiesterase, 3',5'-Cyclic Phosphodiesterase, 3',5'-Cyclic AMP 3,5-Cyclic AMP Phosphodiesterase 3,5 Cyclic AMP Phosphodiesterase AMP Phosphodiesterase, 3,5-Cyclic Phosphodiesterase, 3,5-Cyclic AMP 3',5'-Cyclic Nucleotide Phosphodiesterase 3',5' Cyclic Nucleotide Phosphodiesterase Nucleotide Phosphodiesterase, 3',5'-Cyclic Phosphodiesterase, 3',5'-Cyclic Nucleotide 3',5'-Cyclic-Nucleotide Phosphodiesterase Phosphodiesterase, 3',5'-Cyclic-Nucleotide 3',5'-Nucleotide Phosphodiesterase 3',5' Nucleotide Phosphodiesterase Phosphodiesterase, 3',5'-Nucleotide CAMP Phosphodiesterase Phosphodiesterase, CAMP 3,5-Cyclic AMP 5-Nucleotidohydrolase 3,5 Cyclic AMP 5 Nucleotidohydrolase 5-Nucleotidohydrolase, 3,5-Cyclic AMP AMP 5-Nucleotidohydrolase, 3,5-Cyclic 3',5'-Cyclic-AMP Phosphodiesterase Phosphodiesterase, 3',5'-Cyclic-AMP

Below are MeSH descriptors whose meaning is more general than "3',5'-Cyclic-AMP Phosphodiesterases".

Chemicals and Drugs [D]
Enzymes and Coenzymes [D08]
Enzymes [D08.811]
Hydrolases [D08.811.277]
Esterases [D08.811.277.352]
Phosphoric Diester Hydrolases [D08.811.277.352.640]
3',5'-Cyclic-AMP Phosphodiesterases [D08.811.277.352.640.150]
Amino Acids, Peptides, and Proteins [D12]
Peptides [D12.644]
Intracellular Signaling Peptides and Proteins [D12.644.360]
3',5'-Cyclic-AMP Phosphodiesterases [D12.644.360.008]
Proteins [D12.776]
Intracellular Signaling Peptides and Proteins [D12.776.476]
3',5'-Cyclic-AMP Phosphodiesterases [D12.776.476.008]

Below are MeSH descriptors whose meaning is related to "3',5'-Cyclic-AMP Phosphodiesterases".

Below are MeSH descriptors whose meaning is more specific than "3',5'-Cyclic-AMP Phosphodiesterases".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "3',5'-Cyclic-AMP Phosphodiesterases" by people in this website by year, and whether "3',5'-Cyclic-AMP Phosphodiesterases" was a major or minor topic of these publications.

Bar chart showing 14 publications over 10 distinct years, with a maximum of 4 publications in 2005

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1998	0	1	1
1999	1	0	1
2000	0	1	1
2001	0	1	1
2002	0	1	1
2003	1	0	1
2004	0	1	1
2005	4	0	4
2007	2	0	2
2014	1	0	1

Below are the most recent publications written about "3',5'-Cyclic-AMP Phosphodiesterases" by people in Profiles.

Integrated analysis of transcriptomes of cancer cell lines and patient samples reveals STK11/LKB1-driven regulation of cAMP phosphodiesterase-4D. Mol Cancer Ther. 2014 Oct; 13(10):2463-73.

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Regulation of phosphodiesterase 3 and inducible cAMP early repressor in the heart. Circ Res. 2007 Mar 02; 100(4):489-501.

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Activation of extracellular signal-regulated kinase 5 reduces cardiac apoptosis and dysfunction via inhibition of a phosphodiesterase 3A/inducible cAMP early repressor feedback loop. Circ Res. 2007 Mar 02; 100(4):510-9.

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Phosphodiesterase 4D deficiency in the ryanodine-receptor complex promotes heart failure and arrhythmias. Cell. 2005 Oct 07; 123(1):25-35.

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A positive feedback loop of phosphodiesterase 3 (PDE3) and inducible cAMP early repressor (ICER) leads to cardiomyocyte apoptosis. Proc Natl Acad Sci U S A. 2005 Oct 11; 102(41):14771-6.

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Functional role of phosphodiesterase 3 in cardiomyocyte apoptosis: implication in heart failure. Circulation. 2005 May 17; 111(19):2469-2476.

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Selective phosphodiesterase-4 inhibitors in chronic obstructive lung disease. Curr Opin Pulm Med. 2005 Mar; 11(2):129-34.

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Periodic signaling controlled by an oscillatory circuit that includes protein kinases ERK2 and PKA. Science. 2004 May 07; 304(5672):875-8.

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Role of phosphodiesterase 3 in NO/cGMP-mediated antiinflammatory effects in vascular smooth muscle cells. Circ Res. 2003 Sep 05; 93(5):406-13.

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Regulation of neurogenesis in adult mouse hippocampus by cAMP and the cAMP response element-binding protein. J Neurosci. 2002 May 01; 22(9):3673-82.

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