Cyclic Nucleotide Phosphodiesterases, Type 6
"Cyclic Nucleotide Phosphodiesterases, Type 6" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A cyclic nucleotide phosphodiesterase subfamily that is highly specific for CYCLIC GMP. It is found predominantly in the outer segment PHOTORECEPTOR CELLS of the RETINA. It is comprised of two catalytic subunits, referred to as alpha and beta, that form a dimer. In addition two regulatory subunits, referred to as gamma and delta, modulate the activity and localization of the enzyme.
| Descriptor ID |
D054707
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| MeSH Number(s) |
D08.811.277.352.640.150.600 D08.811.277.352.640.155.750 D12.644.360.008.600 D12.644.360.009.750 D12.776.476.008.600 D12.776.476.009.750
|
| Concept/Terms |
Cyclic Nucleotide Phosphodiesterases, Type 6- Cyclic Nucleotide Phosphodiesterases, Type 6
- Phosphodiesterase 6
- PDE6 Phosphodiesterases
- Phosphodiesterases, PDE6
- Retinal Phosphodiesterase 6
- Phosphodiesterase 6, Retinal
- Phosphodiesterase Type 6
|
Below are MeSH descriptors whose meaning is more general than "Cyclic Nucleotide Phosphodiesterases, Type 6".
- Chemicals and Drugs [D]
- Enzymes and Coenzymes [D08]
- Enzymes [D08.811]
- Hydrolases [D08.811.277]
- Esterases [D08.811.277.352]
- Phosphoric Diester Hydrolases [D08.811.277.352.640]
- 3',5'-Cyclic-AMP Phosphodiesterases [D08.811.277.352.640.150]
- Cyclic Nucleotide Phosphodiesterases, Type 6 [D08.811.277.352.640.150.600]
- 3',5'-Cyclic-GMP Phosphodiesterases [D08.811.277.352.640.155]
- Cyclic Nucleotide Phosphodiesterases, Type 6 [D08.811.277.352.640.155.750]
- Amino Acids, Peptides, and Proteins [D12]
- Peptides [D12.644]
- Intracellular Signaling Peptides and Proteins [D12.644.360]
- 3',5'-Cyclic-AMP Phosphodiesterases [D12.644.360.008]
- Cyclic Nucleotide Phosphodiesterases, Type 6 [D12.644.360.008.600]
- 3',5'-Cyclic-GMP Phosphodiesterases [D12.644.360.009]
- Cyclic Nucleotide Phosphodiesterases, Type 6 [D12.644.360.009.750]
- Proteins [D12.776]
- Intracellular Signaling Peptides and Proteins [D12.776.476]
- 3',5'-Cyclic-AMP Phosphodiesterases [D12.776.476.008]
- Cyclic Nucleotide Phosphodiesterases, Type 6 [D12.776.476.008.600]
- 3',5'-Cyclic-GMP Phosphodiesterases [D12.776.476.009]
- Cyclic Nucleotide Phosphodiesterases, Type 6 [D12.776.476.009.750]
Below are MeSH descriptors whose meaning is more specific than "Cyclic Nucleotide Phosphodiesterases, Type 6".
This graph shows the total number of publications written about "Cyclic Nucleotide Phosphodiesterases, Type 6" by people in this website by year, and whether "Cyclic Nucleotide Phosphodiesterases, Type 6" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2000 | 0 | 4 | 4 |
| 2001 | 0 | 1 | 1 |
| 2003 | 0 | 2 | 2 |
| 2008 | 1 | 0 | 1 |
| 2015 | 1 | 0 | 1 |
| 2021 | 1 | 0 | 1 |
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Below are the most recent publications written about "Cyclic Nucleotide Phosphodiesterases, Type 6" by people in Profiles.
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Development of PDE6D and CK1a Degraders through Chemical Derivatization of FPFT-2216. J Med Chem. 2022 01 13; 65(1):747-756.
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Domain organization and conformational plasticity of the G protein effector, PDE6. J Biol Chem. 2015 May 15; 290(20):12833-43.
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The GDI-like solubilizing factor PDEd sustains the spatial organization and signalling of Ras family proteins. Nat Cell Biol. 2011 Dec 18; 14(2):148-58.
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New mouse models for recessive retinitis pigmentosa caused by mutations in the Pde6a gene. Hum Mol Genet. 2009 Jan 01; 18(1):178-92.
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Sp4 is expressed in retinal neurons, activates transcription of photoreceptor-specific genes, and synergizes with Crx. J Biol Chem. 2005 May 27; 280(21):20642-50.
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Photoreceptor degeneration and rd1 mutation in the grizzled/mocha mouse strain. Vision Res. 2003 Apr; 43(8):859-65.
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GTPase regulators and photoresponses in cones of the eastern chipmunk. J Neurosci. 2003 Feb 15; 23(4):1287-97.
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Structural determinants for regulation of phosphodiesterase by a G protein at 2.0 A. Nature. 2001 Feb 22; 409(6823):1071-7.
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Modules in the photoreceptor RGS9-1.Gbeta 5L GTPase-accelerating protein complex control effector coupling, GTPase acceleration, protein folding, and stability. J Biol Chem. 2000 Nov 24; 275(47):37093-100.
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Multiple zinc binding sites in retinal rod cGMP phosphodiesterase, PDE6alpha beta. J Biol Chem. 2000 Jul 07; 275(27):20572-7.