Phosphoric Diester Hydrolases
"Phosphoric Diester Hydrolases" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A class of enzymes that catalyze the hydrolysis of one of the two ester bonds in a phosphodiester compound. EC 3.1.4.
| Descriptor ID |
D010727
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| MeSH Number(s) |
D08.811.277.352.640
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "Phosphoric Diester Hydrolases".
Below are MeSH descriptors whose meaning is more specific than "Phosphoric Diester Hydrolases".
This graph shows the total number of publications written about "Phosphoric Diester Hydrolases" by people in this website by year, and whether "Phosphoric Diester Hydrolases" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1996 | 0 | 1 | 1 |
| 2001 | 0 | 1 | 1 |
| 2002 | 2 | 0 | 2 |
| 2003 | 1 | 2 | 3 |
| 2005 | 2 | 4 | 6 |
| 2006 | 0 | 2 | 2 |
| 2008 | 2 | 0 | 2 |
| 2009 | 2 | 5 | 7 |
| 2010 | 1 | 4 | 5 |
| 2011 | 1 | 5 | 6 |
| 2012 | 5 | 2 | 7 |
| 2013 | 3 | 1 | 4 |
| 2014 | 0 | 3 | 3 |
| 2015 | 1 | 0 | 1 |
| 2016 | 0 | 2 | 2 |
| 2017 | 1 | 0 | 1 |
| 2018 | 2 | 0 | 2 |
| 2019 | 1 | 1 | 2 |
| 2020 | 0 | 1 | 1 |
| 2021 | 1 | 0 | 1 |
| 2023 | 0 | 1 | 1 |
| 2024 | 1 | 1 | 2 |
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Below are the most recent publications written about "Phosphoric Diester Hydrolases" by people in Profiles.
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ASCC1 structures and bioinformatics reveal a novel helix-clasp-helix RNA-binding motif linked to a two-histidine phosphodiesterase. J Biol Chem. 2024 Jun; 300(6):107368.
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Haploinsufficiency of phosphodiesterase 10A activates PI3K/AKT signaling independent of PTEN to induce an aggressive glioma phenotype. Genes Dev. 2024 04 17; 38(5-6):273-288.
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High throughput single cell long-read sequencing analyses of same-cell genotypes and phenotypes in human tumors. Nat Commun. 2023 07 11; 14(1):4124.
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Direct interaction of DNA repair protein tyrosyl DNA phosphodiesterase 1 and the DNA ligase III catalytic domain is regulated by phosphorylation of its flexible N-terminus. J Biol Chem. 2021 Aug; 297(2):100921.
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Preclinical Studies of the Off-Target Reactivity of AFP158-Specific TCR Engineered T Cells. Front Immunol. 2020; 11:607.
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Identification of multiple male reproductive tract-specific proteins that regulate sperm migration through the oviduct in mice. Proc Natl Acad Sci U S A. 2019 09 10; 116(37):18498-18506.
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A Stromal Lysolipid-Autotaxin Signaling Axis Promotes Pancreatic Tumor Progression. Cancer Discov. 2019 05; 9(5):617-627.
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Autotaxin exacerbates tumor progression by enhancing MEK1 and overriding the function of miR-489-3p. Cancer Lett. 2018 09 28; 432:84-92.
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Preclinical evaluation of NUDT15-guided thiopurine therapy and its effects on toxicity and antileukemic efficacy. Blood. 2018 05 31; 131(22):2466-2474.
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Common TDP1 Polymorphisms in Relation to Survival among Small Cell Lung Cancer Patients: A Multicenter Study from the International Lung Cancer Consortium. Clin Cancer Res. 2017 Dec 15; 23(24):7550-7557.