"Calmodulin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A heat-stable, low-molecular-weight activator protein found mainly in the brain and heart. The binding of calcium ions to this protein allows this protein to bind to cyclic nucleotide phosphodiesterases and to adenyl cyclase with subsequent activation. Thereby this protein modulates cyclic AMP and cyclic GMP levels.
| Descriptor ID |
D002147
|
| MeSH Number(s) |
D12.644.360.372.249 D12.776.157.125.412.249 D12.776.476.387.249
|
| Concept/Terms |
Calmodulin- Calmodulin
- Calcium-Dependent Regulator
- Calcium Dependent Regulator
- Calcium-Dependent Activator Protein
- Activator Protein, Calcium-Dependent
- Calcium Dependent Activator Protein
- Protein, Calcium-Dependent Activator
- Phosphodiesterase Protein Activator
- Activator, Phosphodiesterase Protein
- Protein Activator, Phosphodiesterase
- Phosphodiesterase Activating Factor
- Activating Factor, Phosphodiesterase
- Factor, Phosphodiesterase Activating
- Phosphodiesterase Activator Protein
- Activator Protein, Phosphodiesterase
- Protein, Phosphodiesterase Activator
- Regulator, Calcium-Dependent
- Regulator, Calcium Dependent
Cyclic AMP-Phosphodiesterase Activator- Cyclic AMP-Phosphodiesterase Activator
- AMP-Phosphodiesterase Activator, Cyclic
- Activator, Cyclic AMP-Phosphodiesterase
- Cyclic AMP Phosphodiesterase Activator
|
Below are MeSH descriptors whose meaning is more general than "Calmodulin".
Below are MeSH descriptors whose meaning is more specific than "Calmodulin".
This graph shows the total number of publications written about "Calmodulin" by people in this website by year, and whether "Calmodulin" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1996 | 3 | 1 | 4 |
| 1997 | 4 | 0 | 4 |
| 1998 | 0 | 1 | 1 |
| 1999 | 3 | 1 | 4 |
| 2000 | 7 | 1 | 8 |
| 2001 | 2 | 1 | 3 |
| 2002 | 7 | 0 | 7 |
| 2003 | 4 | 0 | 4 |
| 2004 | 1 | 1 | 2 |
| 2005 | 2 | 2 | 4 |
| 2006 | 1 | 0 | 1 |
| 2007 | 1 | 1 | 2 |
| 2009 | 3 | 1 | 4 |
| 2010 | 1 | 1 | 2 |
| 2011 | 1 | 1 | 2 |
| 2012 | 0 | 3 | 3 |
| 2013 | 1 | 0 | 1 |
| 2014 | 2 | 0 | 2 |
| 2016 | 2 | 1 | 3 |
| 2017 | 3 | 1 | 4 |
| 2019 | 1 | 0 | 1 |
| 2022 | 0 | 1 | 1 |
| 2025 | 1 | 1 | 2 |
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Below are the most recent publications written about "Calmodulin" by people in Profiles.
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Unconventional binding of calmodulin to CHK2 kinase inhibits catalytic activity. Biochem J. 2025 Dec 03; 482(23).
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PSKH1 kinase activity is differentially modulated via allosteric binding of Ca2+ sensor proteins. Proc Natl Acad Sci U S A. 2025 Feb 25; 122(8):e2420961122.
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Loss of Activity-Induced Mitochondrial ATP Production Underlies the Synaptic Defects in a Drosophila Model of ALS. J Neurosci. 2022 10 19; 42(42):8019-8037.
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Assessing predictions on fitness effects of missense variants in calmodulin. Hum Mutat. 2019 09; 40(9):1463-1473.
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EL20, a potent antiarrhythmic compound, selectively inhibits calmodulin-deficient ryanodine receptor type 2. Heart Rhythm. 2018 04; 15(4):578-586.
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Calcium-calmodulin-dependent protein kinase mediates the intracellular signalling pathways of cardiac apoptosis in mice with impaired glucose tolerance. J Physiol. 2017 06 15; 595(12):4089-4108.
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Impact of Genetic Variation on Human CaMKK2 Regulation by Ca2+-Calmodulin and Multisite Phosphorylation. Sci Rep. 2017 02 23; 7:43264.
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In vivo three-photon imaging of activity of GCaMP6-labeled neurons deep in intact mouse brain. Nat Methods. 2017 Apr; 14(4):388-390.
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The Ca(2+)/Calmodulin/CaMKK2 Axis: Nature's Metabolic CaMshaft. Trends Endocrinol Metab. 2016 10; 27(10):706-718.
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CaMKII-dependent phosphorylation of RyR2 promotes targetable pathological RyR2 conformational shift. J Mol Cell Cardiol. 2016 09; 98:62-72.