"Calreticulin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A multifunctional protein that is found primarily within membrane-bound organelles. In the ENDOPLASMIC RETICULUM it binds to specific N-linked oligosaccharides found on newly-synthesized proteins and functions as a MOLECULAR CHAPERONE that may play a role in PROTEIN FOLDING or retention and degradation of misfolded proteins. In addition calreticulin is a major storage form for CALCIUM and functions as a calcium-signaling molecule that can regulate intracellular calcium HOMEOSTASIS.
Descriptor ID |
D037282
|
MeSH Number(s) |
D12.644.360.372.374 D12.776.157.125.412.374 D12.776.476.387.374 D12.776.503.303
|
Concept/Terms |
Calreticulin- Calreticulin
- CAB-63
- CBP3 (Liver)
- ERp60
- cC1qR Protein
- Calcium-Binding Protein-3
- Calcium Binding Protein 3
- Calregulin
- 55-kDa High-Affinity Calcium Binding Protein
- 55 kDa High Affinity Calcium Binding Protein
- HACBP
|
Below are MeSH descriptors whose meaning is more general than "Calreticulin".
Below are MeSH descriptors whose meaning is more specific than "Calreticulin".
This graph shows the total number of publications written about "Calreticulin" by people in this website by year, and whether "Calreticulin" was a major or minor topic of these publications.
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Year | Major Topic | Minor Topic | Total |
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2000 | 0 | 1 | 1 |
2002 | 0 | 1 | 1 |
2003 | 1 | 0 | 1 |
2004 | 2 | 1 | 3 |
2012 | 1 | 0 | 1 |
2015 | 2 | 3 | 5 |
2016 | 4 | 2 | 6 |
2017 | 1 | 0 | 1 |
2018 | 0 | 2 | 2 |
2019 | 0 | 2 | 2 |
2020 | 2 | 2 | 4 |
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Below are the most recent publications written about "Calreticulin" by people in Profiles.
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Tipping the immunostimulatory and inhibitory DAMP balance to harness immunogenic cell death. Nat Commun. 2020 12 07; 11(1):6299.
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Trichinella spiralis Calreticulin S-Domain Binds to Human Complement C1q to Interfere With C1q-Mediated Immune Functions. Front Immunol. 2020; 11:572326.
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Chronic myeloid neoplasms harboring concomitant mutations in myeloproliferative neoplasm driver genes (JAK2/MPL/CALR) and SF3B1. Mod Pathol. 2021 01; 34(1):20-31.
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Sclerosing Extramedullary Hematopoietic Tumor: A Case Report. J Investig Med High Impact Case Rep. 2020 Jan-Dec; 8:2324709620956463.
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Mutational profiling in myelofibrosis: implications for management. Int J Hematol. 2020 Feb; 111(2):192-199.
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Myelofibrosis osteoclasts are clonal and functionally impaired. Blood. 2019 05 23; 133(21):2320-2324.
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Recent advances in the genomics and therapy of BCR/ABL1-positive and -negative chronic myeloproliferative neoplasms. Leuk Res. 2018 04; 67:67-74.
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Significance of thrombocytopenia in patients with primary and postessential thrombocythemia/polycythemia vera myelofibrosis. Eur J Haematol. 2018 Mar; 100(3):257-263.
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Calreticulin as a novel B-cell receptor antigen in chronic lymphocytic leukemia. Haematologica. 2017 10; 102(10):e394-e396.
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Myeloproliferative Neoplasms, Version 2.2017, NCCN Clinical Practice Guidelines in Oncology. J Natl Compr Canc Netw. 2016 12; 14(12):1572-1611.