Proliferating Cell Nuclear Antigen
"Proliferating Cell Nuclear Antigen" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Nuclear antigen with a role in DNA synthesis, DNA repair, and cell cycle progression. PCNA is required for the coordinated synthesis of both leading and lagging strands at the replication fork during DNA replication. PCNA expression correlates with the proliferation activity of several malignant and non-malignant cell types.
| Descriptor ID |
D018809
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| MeSH Number(s) |
D12.776.660.740 D23.050.290.750 D23.101.140.600
|
| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Proliferating Cell Nuclear Antigen".
Below are MeSH descriptors whose meaning is more specific than "Proliferating Cell Nuclear Antigen".
This graph shows the total number of publications written about "Proliferating Cell Nuclear Antigen" by people in this website by year, and whether "Proliferating Cell Nuclear Antigen" was a major or minor topic of these publications.
To see the data from this visualization as text,
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1994 | 6 | 4 | 10 |
| 1995 | 7 | 10 | 17 |
| 1996 | 5 | 5 | 10 |
| 1997 | 2 | 6 | 8 |
| 1998 | 4 | 7 | 11 |
| 1999 | 0 | 2 | 2 |
| 2000 | 3 | 5 | 8 |
| 2001 | 1 | 1 | 2 |
| 2002 | 1 | 10 | 11 |
| 2003 | 0 | 6 | 6 |
| 2004 | 2 | 4 | 6 |
| 2005 | 0 | 1 | 1 |
| 2006 | 9 | 5 | 14 |
| 2007 | 1 | 4 | 5 |
| 2008 | 3 | 4 | 7 |
| 2009 | 1 | 3 | 4 |
| 2010 | 2 | 3 | 5 |
| 2011 | 2 | 0 | 2 |
| 2012 | 5 | 3 | 8 |
| 2013 | 4 | 2 | 6 |
| 2014 | 0 | 1 | 1 |
| 2015 | 4 | 0 | 4 |
| 2016 | 1 | 2 | 3 |
| 2017 | 1 | 0 | 1 |
| 2019 | 0 | 2 | 2 |
| 2021 | 1 | 1 | 2 |
| 2023 | 0 | 3 | 3 |
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Below are the most recent publications written about "Proliferating Cell Nuclear Antigen" by people in Profiles.
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Lysosome-dependent FOXA1 ubiquitination contributes to luminal lineage of advanced prostate cancer. Mol Oncol. 2023 10; 17(10):2126-2146.
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2023 AHA/ACC/ACCP/ASPC/NLA/PCNA Guideline for the Management of Patients With Chronic Coronary Disease: A Report of the American Heart Association/American College of Cardiology Joint Committee on Clinical Practice Guidelines. Circulation. 2023 08 29; 148(9):e9-e119.
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2023 AHA/ACC/ACCP/ASPC/NLA/PCNA Guideline for the Management of Patients With Chronic?Coronary Disease: A Report of the American Heart Association/American College of Cardiology Joint Committee on Clinical Practice Guidelines. J Am Coll Cardiol. 2023 08 29; 82(9):833-955.
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Translesion polymerase eta both facilitates DNA replication and promotes increased human genetic variation at common fragile sites. Proc Natl Acad Sci U S A. 2021 11 30; 118(48).
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Evading immune surveillance via tyrosine phosphorylation of nuclear PCNA. Cell Rep. 2021 08 24; 36(8):109537.
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Nuclear receptors regulate alternative lengthening of telomeres through a novel noncanonical FANCD2 pathway. Sci Adv. 2019 10; 5(10):eaax6366.
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The DNA repair protein SHPRH is a nucleosome-stimulated ATPase and a nucleosome-E3 ubiquitin ligase. Epigenetics Chromatin. 2019 08 21; 12(1):52.
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Potential implications of redefining the hypertriglyceridemia of metabolic syndrome. Horm Mol Biol Clin Investig. 2019 06 20; 40(1).
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Small Molecule Docking of DNA Repair Proteins Associated with Cancer Survival Following PCNA Metagene Adjustment: A Potential Novel Class of Repair Inhibitors. Molecules. 2019 Feb 12; 24(3).
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Genetic Screens Reveal FEN1 and APEX2 as BRCA2 Synthetic Lethal Targets. Mol Cell. 2019 03 07; 73(5):885-899.e6.