Proliferating Cell Nuclear Antigen
"Proliferating Cell Nuclear Antigen" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Nuclear antigen with a role in DNA synthesis, DNA repair, and cell cycle progression. PCNA is required for the coordinated synthesis of both leading and lagging strands at the replication fork during DNA replication. PCNA expression correlates with the proliferation activity of several malignant and non-malignant cell types.
| Descriptor ID |
D018809
|
| MeSH Number(s) |
D12.776.660.740 D23.050.290.750 D23.101.140.600
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "Proliferating Cell Nuclear Antigen".
Below are MeSH descriptors whose meaning is more specific than "Proliferating Cell Nuclear Antigen".
This graph shows the total number of publications written about "Proliferating Cell Nuclear Antigen" by people in this website by year, and whether "Proliferating Cell Nuclear Antigen" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1996 | 0 | 1 | 1 |
| 1997 | 1 | 2 | 3 |
| 1999 | 1 | 1 | 2 |
| 2000 | 1 | 2 | 3 |
| 2002 | 0 | 2 | 2 |
| 2003 | 1 | 0 | 1 |
| 2004 | 0 | 2 | 2 |
| 2006 | 1 | 1 | 2 |
| 2007 | 0 | 1 | 1 |
| 2008 | 2 | 2 | 4 |
| 2009 | 1 | 0 | 1 |
| 2010 | 0 | 1 | 1 |
| 2012 | 0 | 1 | 1 |
| 2014 | 0 | 1 | 1 |
| 2016 | 0 | 1 | 1 |
| 2017 | 1 | 0 | 1 |
| 2019 | 0 | 2 | 2 |
| 2023 | 0 | 3 | 3 |
To return to the timeline,
click here.
Below are the most recent publications written about "Proliferating Cell Nuclear Antigen" by people in Profiles.
-
Nuclear receptors regulate alternative lengthening of telomeres through a novel noncanonical FANCD2 pathway. Sci Adv. 2019 10; 5(10):eaax6366.
-
Induction of cell death by the novel proteasome inhibitor marizomib in glioblastoma in vitro and in vivo. Sci Rep. 2016 Jan 25; 6:18953.
-
Overexpression of membrane metalloendopeptidase inhibits substance P stimulation of cholangiocarcinoma growth. Am J Physiol Gastrointest Liver Physiol. 2014 May 01; 306(9):G759-68.
-
BRCA1 promotes the ubiquitination of PCNA and recruitment of translesion polymerases in response to replication blockade. Proc Natl Acad Sci U S A. 2013 Aug 13; 110(33):13558-63.
-
Impaired replication elongation in Tetrahymena mutants deficient in histone H3 Lys 27 monomethylation. Genes Dev. 2013 Aug 01; 27(15):1662-79.
-
Changes in the biological characteristics of glioma cancer stem cells after serial in vivo subtransplantation. Childs Nerv Syst. 2013 Jan; 29(1):55-64.
-
Proliferating cell nuclear antigen (PCNA)-binding protein C1orf124 is a regulator of translesion synthesis. J Biol Chem. 2012 Oct 05; 287(41):34225-33.
-
The HARP-like domain-containing protein AH2/ZRANB3 binds to PCNA and participates in cellular response to replication stress. Mol Cell. 2012 Aug 10; 47(3):410-21.
-
RAD18 lives a double life: Its implication in DNA double-strand break repair. DNA Repair (Amst). 2010 Dec 10; 9(12):1241-8.
-
Rapid and transient recruitment of DNMT1 to DNA double-strand breaks is mediated by its interaction with multiple components of the DNA damage response machinery. Hum Mol Genet. 2011 Jan 01; 20(1):126-40.