"Hepcidins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Forms of hepcidin, a cationic amphipathic peptide synthesized in the liver as a prepropeptide which is first processed into prohepcidin and then into the biologically active hepcidin forms, including in human the 20-, 22-, and 25-amino acid residue peptide forms. Hepcidin acts as a homeostatic regulators of iron metabolism and also possesses antimicrobial activity.
| Descriptor ID |
D064451
|
| MeSH Number(s) |
D12.776.494.249 D12.776.543.695.054.425
|
| Concept/Terms |
Hepcidins- Hepcidins
- Liver-Expressed Antimicrobial Peptide
- Antimicrobial Peptide, Liver-Expressed
- Liver Expressed Antimicrobial Peptide
- Peptide, Liver-Expressed Antimicrobial
- Hepcidin
|
Below are MeSH descriptors whose meaning is more general than "Hepcidins".
Below are MeSH descriptors whose meaning is more specific than "Hepcidins".
This graph shows the total number of publications written about "Hepcidins" by people in this website by year, and whether "Hepcidins" was a major or minor topic of these publications.
To see the data from this visualization as text,
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2002 | 0 | 1 | 1 |
| 2006 | 0 | 1 | 1 |
| 2007 | 0 | 3 | 3 |
| 2009 | 0 | 4 | 4 |
| 2010 | 0 | 1 | 1 |
| 2011 | 0 | 1 | 1 |
| 2013 | 1 | 1 | 2 |
| 2014 | 1 | 0 | 1 |
| 2016 | 1 | 0 | 1 |
| 2019 | 1 | 2 | 3 |
| 2020 | 2 | 0 | 2 |
| 2021 | 1 | 0 | 1 |
| 2022 | 0 | 1 | 1 |
| 2023 | 0 | 2 | 2 |
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Below are the most recent publications written about "Hepcidins" by people in Profiles.
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Rusfertide for the treatment of iron overload in HFE-related haemochromatosis: an open-label, multicentre, proof-of-concept phase 2 trial. Lancet Gastroenterol Hepatol. 2023 12; 8(12):1118-1128.
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Structural basis of ferroportin inhibition by minihepcidin PR73. PLoS Biol. 2023 01; 21(1):e3001936.
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Erythropoietic effects of vadadustat in patients with anemia associated with chronic kidney disease. Am J Hematol. 2022 09; 97(9):1178-1188.
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Do Extremely Low Gestational Age Neonates Regulate Iron Absorption via Hepcidin? J Pediatr. 2022 02; 241:62-67.e1.
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Structural basis of ion transport and inhibition in ferroportin. Nat Commun. 2020 11 10; 11(1):5686.
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Iron supplementation in infants: a reflection on hepcidin and fractional iron absorption. Am J Clin Nutr. 2020 10 01; 112(4):909-910.
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A step toward an expanded iron toolkit: Hepcidin values in healthy Dutch children. Pediatr Blood Cancer. 2020 03; 67(3):e28122.
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Disorders of Iron Metabolism: New Diagnostic and Treatment Approaches to Iron Deficiency. Hematol Oncol Clin North Am. 2019 06; 33(3):393-408.
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Dietary restriction of iron availability attenuates UPEC pathogenesis in a mouse model of urinary tract infection. Am J Physiol Renal Physiol. 2019 05 01; 316(5):F814-F822.
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Increased serum hepcidin contributes to the anemia of chronic kidney disease in a murine model. Haematologica. 2017 03; 102(3):e85-e88.