"Ataxin-2" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A Poly(A) RNA-binding protein that negatively regulates EGFR ENDOCYTOSIS. An increased risk for developing AMYOTROPHIC LATERAL SCLEROSIS 13 is observed in patients who have more than 23 CAG repeats in the ATXN2 gene coding sequence. Larger CAG expansions in the ATXN2 gene occur in SPINOCEREBELLAR ATAXIA 2 patients.
| Descriptor ID |
D000067698
|
| MeSH Number(s) |
D12.776.157.725.452.125 D12.776.631.069.750 D12.776.660.075.750 D12.776.664.962.452.125
|
| Concept/Terms |
Ataxin-2- Ataxin-2
- Ataxin 2
- Ataxin-2 Protein
- Ataxin 2 Protein
- Protein, Ataxin-2
- Spinocerebellar Ataxia Type 2 Protein
- ATXN2 Protein
- Protein, ATXN2
- Atx-2 Protein
- Atx 2 Protein
- Protein, Atx-2
- SCA2 Protein
- Protein, SCA2
|
Below are MeSH descriptors whose meaning is more general than "Ataxin-2".
Below are MeSH descriptors whose meaning is more specific than "Ataxin-2".
This graph shows the total number of publications written about "Ataxin-2" by people in this website by year, and whether "Ataxin-2" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2015 | 2 | 0 | 2 |
| 2016 | 1 | 0 | 1 |
| 2017 | 0 | 1 | 1 |
| 2020 | 0 | 1 | 1 |
| 2022 | 0 | 1 | 1 |
| 2023 | 1 | 0 | 1 |
To return to the timeline,
click here.
Below are the most recent publications written about "Ataxin-2" by people in Profiles.
-
Poly(A)-binding protein is an ataxin-2 chaperone that regulates biomolecular condensates. Mol Cell. 2023 Jun 15; 83(12):2020-2034.e6.
-
Genome-wide CRISPR screen reveals v-ATPase as a drug target to lower levels of ALS protein ataxin-2. Cell Rep. 2022 10 25; 41(4):111508.
-
Founder Effects of Spinocerebellar Ataxias in the American Continents and the Caribbean. Cerebellum. 2020 Jun; 19(3):446-458.
-
Stress Granule Assembly Disrupts Nucleocytoplasmic Transport. Cell. 2018 05 03; 173(4):958-971.e17.
-
The evolving genetic risk for sporadic ALS. Neurology. 2017 Jul 18; 89(3):226-233.
-
ATXN2-AS, a gene antisense to ATXN2, is associated with spinocerebellar ataxia type 2 and amyotrophic lateral sclerosis. Ann Neurol. 2016 10; 80(4):600-15.
-
Bolivian kindred with combined spinocerebellar ataxia types 2 and 10. Acta Neurol Scand. 2015 Aug; 132(2):139-42.
-
Genome-wide meta-analysis in alopecia areata resolves HLA associations and reveals two new susceptibility loci. Nat Commun. 2015 Jan 22; 6:5966.