"Ataxin-7" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A component of the STAGA transcription coactivator-HAT complex that functions in Cone Rod Homeobox Protein (CRX)-dependent gene activation. It also stabilizes MICROTUBULES. CAG repeat expansion in the ATXN-7 coding region is associated with the development of SPINOCEREBELLAR ATAXIA 7.
| Descriptor ID |
D000067719
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| MeSH Number(s) |
D12.776.631.069.901 D12.776.660.075.900
|
| Concept/Terms |
Ataxin-7- Ataxin-7
- Ataxin 7
- SCA7 Protein
- Protein, SCA7
- Atxn-7 Protein
- Atxn 7 Protein
- Protein, Atxn-7
- Spinocerebellar Ataxia 7 Protein
- ATXN7 Protein
- Protein, ATXN7
|
Below are MeSH descriptors whose meaning is more general than "Ataxin-7".
Below are MeSH descriptors whose meaning is more specific than "Ataxin-7".
This graph shows the total number of publications written about "Ataxin-7" by people in this website by year, and whether "Ataxin-7" was a major or minor topic of these publications.
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click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1998 | 0 | 1 | 1 |
| 1999 | 0 | 1 | 1 |
| 2003 | 0 | 1 | 1 |
| 2005 | 0 | 2 | 2 |
| 2006 | 0 | 1 | 1 |
| 2008 | 0 | 1 | 1 |
| 2010 | 0 | 1 | 1 |
| 2011 | 0 | 1 | 1 |
| 2012 | 0 | 1 | 1 |
| 2015 | 0 | 1 | 1 |
| 2021 | 0 | 1 | 1 |
| 2024 | 0 | 1 | 1 |
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Below are the most recent publications written about "Ataxin-7" by people in Profiles.
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Respiratory neuropathology in spinocerebellar ataxia type 7. JCI Insight. 2024 Jul 18; 9(18).
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A novel ubiquitin-proteasome system regulation of Sgf73/ataxin-7 that maintains the integrity of the coactivator SAGA in orchestrating transcription. Genetics. 2023 07 06; 224(3).
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Respiratory dysfunction in a mouse model of spinocerebellar ataxia type 7. Dis Model Mech. 2021 07 01; 14(7).
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X-linked ADGRG2 mutation and obstructive azoospermia in a large Pakistani family. Sci Rep. 2018 11 02; 8(1):16280.
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Poly(Q) Expansions in ATXN7 Affect Solubility but Not Activity of the SAGA Deubiquitinating Module. Mol Cell Biol. 2015 May; 35(10):1777-87.
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Direct inhibition of Gcn5 protein catalytic activity by polyglutamine-expanded ataxin-7. J Biol Chem. 2013 Nov 22; 288(47):34266-34275.
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Reelin is a target of polyglutamine expanded ataxin-7 in human spinocerebellar ataxia type 7 (SCA7) astrocytes. Proc Natl Acad Sci U S A. 2012 Dec 26; 109(52):21319-24.
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Gcn5 loss-of-function accelerates cerebellar and retinal degeneration in a SCA7 mouse model. Hum Mol Genet. 2012 Jan 15; 21(2):394-405.
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Comparison of an expanded ataxia interactome with patient medical records reveals a relationship between macular degeneration and ataxia. Hum Mol Genet. 2011 Feb 01; 20(3):510-27.
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The insulin-like growth factor pathway is altered in spinocerebellar ataxia type 1 and type 7. Proc Natl Acad Sci U S A. 2008 Jan 29; 105(4):1291-6.