"Karyopherins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A family of proteins involved in NUCLEOCYTOPLASMIC TRANSPORT. Karyopherins are heteromeric molecules composed two major types of components, ALPHA KARYOPHERINS and BETA KARYOPHERINS, that function together to transport molecules through the NUCLEAR PORE COMPLEX. Several other proteins such as RAN GTP BINDING PROTEIN and CELLULAR APOPTOSIS SUSCEPTIBILITY PROTEIN bind to karyopherins and participate in the transport process.
| Descriptor ID |
D028884
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| MeSH Number(s) |
D12.776.157.530.750.500 D12.776.543.585.750.500 D12.776.660.502
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "Karyopherins".
Below are MeSH descriptors whose meaning is more specific than "Karyopherins".
This graph shows the total number of publications written about "Karyopherins" by people in this website by year, and whether "Karyopherins" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1997 | 1 | 0 | 1 |
| 1998 | 1 | 0 | 1 |
| 1999 | 2 | 0 | 2 |
| 2000 | 1 | 0 | 1 |
| 2006 | 2 | 0 | 2 |
| 2009 | 1 | 0 | 1 |
| 2010 | 1 | 0 | 1 |
| 2015 | 1 | 0 | 1 |
| 2016 | 1 | 0 | 1 |
| 2017 | 2 | 0 | 2 |
| 2018 | 1 | 3 | 4 |
| 2019 | 0 | 2 | 2 |
| 2020 | 2 | 0 | 2 |
| 2021 | 1 | 1 | 2 |
| 2023 | 1 | 0 | 1 |
| 2025 | 1 | 0 | 1 |
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Below are the most recent publications written about "Karyopherins" by people in Profiles.
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Pathogenic XPO1 variants cause a dominant neurodevelopmental disorder. Genet Med. 2025 Nov; 27(11):101555.
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Take your mother's ferry: preimplantation embryo development requires maternal karyopherins for nuclear transport. J Clin Invest. 2023 01 17; 133(2).
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TNPO2 variants associate with human developmental delays, neurologic deficits, and dysmorphic features and alter TNPO2 activity in Drosophila. Am J Hum Genet. 2021 09 02; 108(9):1669-1691.
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A noncanonical microRNA derived from the snaR-A noncoding RNA targets a metastasis inhibitor. RNA. 2021 06; 27(6):694-709.
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XPO1 expression worsens the prognosis of unfavorable DLBCL that can be effectively targeted by selinexor in the absence of mutant p53. J Hematol Oncol. 2020 11 04; 13(1):148.
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Hypertrophic lichenoid dermatitis immune-related adverse event during combined immune checkpoint and exportin inhibitor therapy: A diagnostic pitfall for superficially invasive squamous cell carcinoma. J Cutan Pathol. 2020 Oct; 47(10):954-959.
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C9orf72-generated poly-GR and poly-PR do not directly interfere with nucleocytoplasmic transport. Sci Rep. 2019 10 31; 9(1):15728.
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PACS1 is an HIV-1 cofactor that functions in Rev-mediated nuclear export of viral RNA. Virology. 2020 01 15; 540:88-96.
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Mutant NPM1 Maintains the Leukemic State through HOX Expression. Cancer Cell. 2018 09 10; 34(3):499-512.e9.
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mTOR-dependent phosphorylation controls TFEB nuclear export. Nat Commun. 2018 08 17; 9(1):3312.