"alpha Karyopherins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Nucleocytoplasmic transport molecules that bind to the NUCLEAR LOCALIZATION SIGNALS of cytoplasmic molecules destined to be imported into the CELL NUCLEUS. Once attached to their cargo they bind to BETA KARYOPHERINS and are transported through the NUCLEAR PORE COMPLEX. Inside the CELL NUCLEUS alpha karyopherins dissociate from beta karypherins and their cargo. They then form a complex with CELLULAR APOPTOSIS SUSCEPTIBILITY PROTEIN and RAN GTP-BINDING PROTEIN which is exported to the CYTOPLASM.
| Descriptor ID |
D028901
|
| MeSH Number(s) |
D12.776.157.530.750.500.100 D12.776.543.585.750.500.100 D12.776.660.502.100
|
| Concept/Terms |
alpha Karyopherins- alpha Karyopherins
- Karyopherins, alpha
- Karyopherin alpha
- Nuclear Localization Signal-Binding Protein
- NLS-Binding Protein
- NLSBP
- Nuclear Localization Sequence Receptor
- Importin-alpha
- NLS Receptor
- receptor, NLS
|
Below are MeSH descriptors whose meaning is more general than "alpha Karyopherins".
Below are MeSH descriptors whose meaning is more specific than "alpha Karyopherins".
This graph shows the total number of publications written about "alpha Karyopherins" by people in this website by year, and whether "alpha Karyopherins" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2003 | 0 | 1 | 1 |
| 2005 | 1 | 0 | 1 |
| 2011 | 0 | 1 | 1 |
| 2015 | 1 | 0 | 1 |
| 2020 | 0 | 1 | 1 |
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Below are the most recent publications written about "alpha Karyopherins" by people in Profiles.
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Inherited causes of clonal haematopoiesis in 97,691 whole genomes. Nature. 2020 10; 586(7831):763-768.
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Stress Granule Assembly Disrupts Nucleocytoplasmic Transport. Cell. 2018 05 03; 173(4):958-971.e17.
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Nucleus-Translocated ACSS2 Promotes Gene Transcription for Lysosomal Biogenesis and Autophagy. Mol Cell. 2017 Jun 01; 66(5):684-697.e9.
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Karyopherin a 3 and karyopherin a 4 proteins mediate the nuclear import of methyl-CpG binding protein 2. J Biol Chem. 2015 Sep 11; 290(37):22485-93.
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KPNA6 (Importin {alpha}7)-mediated nuclear import of Keap1 represses the Nrf2-dependent antioxidant response. Mol Cell Biol. 2011 May; 31(9):1800-11.
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Importin-alpha-16 is a translocon-associated protein involved in sorting membrane proteins to the nuclear envelope. Nat Struct Mol Biol. 2006 Jun; 13(6):500-8.
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Tissue transglutaminase: from biological glue to cell survival cues. Front Biosci. 2006 Jan 01; 11:173-85.
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The fission yeast Schizosaccharomyces pombe has two importin-alpha proteins, Imp1p and Cut15p, which have common and unique functions in nucleocytoplasmic transport and cell cycle progression. Genetics. 2005 Sep; 171(1):7-21.
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Catalytic activity is required for calcium/calmodulin-dependent protein kinase IV to enter the nucleus. J Biol Chem. 2004 Mar 19; 279(12):11664-71.
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Nuclear entry of high-risk human papillomavirus type 16 E6 oncoprotein occurs via several pathways. J Virol. 2003 Feb; 77(4):2330-7.