"beta Karyopherins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Nucleocytoplasmic transport molecules that bind to ALPHA KARYOPHERINS in the CYTOSOL and are involved in transport of molecules through the NUCLEAR PORE COMPLEX. Once inside the CELL NUCLEUS beta karyopherins interact with RAN GTP-BINDING PROTEIN and dissociate from alpha karyopherins. Beta karyopherins bound to RAN GTP-BINDING PROTEIN are then re-transported to the cytoplasm where hydrolysis of the GTP of RAN GTP-BINDING PROTEIN causes release of karyopherin beta.
| Descriptor ID |
D028961
|
| MeSH Number(s) |
D12.776.157.530.750.500.249 D12.776.543.585.750.500.249 D12.776.660.502.500
|
| Concept/Terms |
beta Karyopherins- beta Karyopherins
- Karyopherins, beta
- Kap95 protein
- p92 nuclear protein
- nuclear protein, p92
- beta Importins
- Importins, beta
- Karyopherin-beta
- Karyopherin-beta Subunit
- Karyopherin beta Subunit
- Importin-beta
- Importin beta
- Karyopherin beta
|
Below are MeSH descriptors whose meaning is more general than "beta Karyopherins".
Below are MeSH descriptors whose meaning is more specific than "beta Karyopherins".
This graph shows the total number of publications written about "beta Karyopherins" by people in this website by year, and whether "beta Karyopherins" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1999 | 0 | 1 | 1 |
| 2003 | 0 | 2 | 2 |
| 2005 | 1 | 1 | 2 |
| 2006 | 2 | 0 | 2 |
| 2010 | 0 | 1 | 1 |
| 2014 | 2 | 0 | 2 |
| 2015 | 1 | 0 | 1 |
| 2016 | 1 | 0 | 1 |
| 2017 | 1 | 0 | 1 |
| 2019 | 0 | 2 | 2 |
| 2021 | 1 | 0 | 1 |
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click here.
Below are the most recent publications written about "beta Karyopherins" by people in Profiles.
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TNPO2 variants associate with human developmental delays, neurologic deficits, and dysmorphic features and alter TNPO2 activity in Drosophila. Am J Hum Genet. 2021 09 02; 108(9):1669-1691.
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miRNA551b-3p Activates an Oncostatin Signaling Module for the Progression of Triple-Negative Breast Cancer. Cell Rep. 2019 12 24; 29(13):4389-4406.e10.
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Overlap of Genetic Risk between Interstitial Lung Abnormalities and Idiopathic Pulmonary Fibrosis. Am J Respir Crit Care Med. 2019 12 01; 200(11):1402-1413.
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Stress Granule Assembly Disrupts Nucleocytoplasmic Transport. Cell. 2018 05 03; 173(4):958-971.e17.
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Identification of optimal reference genes for transcriptomic analyses in normal and diseased human heart. Cardiovasc Res. 2018 02 01; 114(2):247-258.
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In vivo loss-of-function screens identify KPNB1 as a new druggable oncogene in epithelial ovarian cancer. Proc Natl Acad Sci U S A. 2017 08 29; 114(35):E7301-E7310.
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Stearoyl-CoA Desaturase Promotes Liver Fibrosis and Tumor Development in Mice via a Wnt Positive-Signaling Loop by Stabilization of Low-Density Lipoprotein-Receptor-Related Proteins 5 and 6. Gastroenterology. 2017 05; 152(6):1477-1491.
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Epac1 interacts with importin ?1 and controls neurite outgrowth independently of cAMP and Rap1. Sci Rep. 2016 11 03; 6:36370.
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Antitumor effects of pharmacological EZH2 inhibition on malignant peripheral nerve sheath tumor through the miR-30a and KPNB1 pathway. Mol Cancer. 2015 Mar 07; 14:55.
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The IRF5-TNPO3 association with systemic lupus erythematosus has two components that other autoimmune disorders variably share. Hum Mol Genet. 2015 Jan 15; 24(2):582-96.