"Mad2 Proteins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Mad2 is a component of the spindle-assembly checkpoint apparatus. It binds to and inhibits the Cdc20 activator subunit of the anaphase-promoting complex, preventing the onset of anaphase until all chromosomes are properly aligned at the metaphase plate. Mad2 is required for proper microtubule capture at KINETOCHORES.
| Descriptor ID |
D064246
|
| MeSH Number(s) |
D12.776.167.313 D12.776.660.526
|
| Concept/Terms |
Mad2 Proteins- Mad2 Proteins
- Mad2 Mitotic Arrest Deficient-like 1 Proteins
|
Below are MeSH descriptors whose meaning is more general than "Mad2 Proteins".
Below are MeSH descriptors whose meaning is more specific than "Mad2 Proteins".
This graph shows the total number of publications written about "Mad2 Proteins" by people in this website by year, and whether "Mad2 Proteins" was a major or minor topic of these publications.
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click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1997 | 0 | 1 | 1 |
| 1998 | 0 | 1 | 1 |
| 2002 | 0 | 1 | 1 |
| 2004 | 0 | 2 | 2 |
| 2005 | 0 | 1 | 1 |
| 2006 | 0 | 2 | 2 |
| 2008 | 0 | 3 | 3 |
| 2010 | 1 | 0 | 1 |
| 2012 | 0 | 1 | 1 |
| 2015 | 1 | 0 | 1 |
| 2016 | 1 | 0 | 1 |
| 2017 | 1 | 0 | 1 |
| 2018 | 1 | 0 | 1 |
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Below are the most recent publications written about "Mad2 Proteins" by people in Profiles.
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FAM35A associates with REV7 and modulates DNA?damage responses of normal and BRCA1-defective cells. EMBO J. 2018 06 15; 37(12).
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HNF1B Loss Exacerbates the Development of Chromophobe Renal Cell Carcinomas. Cancer Res. 2017 10 01; 77(19):5313-5326.
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Histone H3K4 methylation regulates deactivation of the spindle assembly checkpoint through direct binding of Mad2. Genes Dev. 2016 05 15; 30(10):1187-97.
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REV7 is essential for DNA damage tolerance via two REV3L binding sites in mammalian DNA polymerase ?. Nucleic Acids Res. 2015 Jan; 43(2):1000-11.
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Role of the Mad2 dimerization interface in the spindle assembly checkpoint independent of kinetochores. Curr Biol. 2012 Oct 23; 22(20):1900-8.
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Overlapping in short motif sequences for binding to human REV7 and MAD2 proteins. Genes Cells. 2010 Mar; 15(3):281-96.
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Control of chromosome stability by the beta-TrCP-REST-Mad2 axis. Nature. 2008 Mar 20; 452(7185):365-9.
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Insights into mad2 regulation in the spindle checkpoint revealed by the crystal structure of the symmetric mad2 dimer. PLoS Biol. 2008 Mar 04; 6(3):e50.
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DNA polymerase zeta (pol zeta) in higher eukaryotes. Cell Res. 2008 Jan; 18(1):174-83.
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Anaphase initiation is regulated by antagonistic ubiquitination and deubiquitination activities. Nature. 2007 Apr 19; 446(7138):876-81.