"Mad2 Proteins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Mad2 is a component of the spindle-assembly checkpoint apparatus. It binds to and inhibits the Cdc20 activator subunit of the anaphase-promoting complex, preventing the onset of anaphase until all chromosomes are properly aligned at the metaphase plate. Mad2 is required for proper microtubule capture at KINETOCHORES.
| Descriptor ID |
D064246
|
| MeSH Number(s) |
D12.776.167.313 D12.776.660.526
|
| Concept/Terms |
Mad2 Proteins- Mad2 Proteins
- Mad2 Mitotic Arrest Deficient-like 1 Proteins
|
Below are MeSH descriptors whose meaning is more general than "Mad2 Proteins".
Below are MeSH descriptors whose meaning is more specific than "Mad2 Proteins".
This graph shows the total number of publications written about "Mad2 Proteins" by people in this website by year, and whether "Mad2 Proteins" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1997 | 0 | 1 | 1 |
| 1998 | 0 | 1 | 1 |
| 2002 | 0 | 1 | 1 |
| 2004 | 0 | 1 | 1 |
| 2016 | 1 | 0 | 1 |
| 2017 | 1 | 0 | 1 |
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Below are the most recent publications written about "Mad2 Proteins" by people in Profiles.
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HNF1B Loss Exacerbates the Development of Chromophobe Renal Cell Carcinomas. Cancer Res. 2017 10 01; 77(19):5313-5326.
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Histone H3K4 methylation regulates deactivation of the spindle assembly checkpoint through direct binding of Mad2. Genes Dev. 2016 05 15; 30(10):1187-97.
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DNA polymerase zeta (pol zeta) in higher eukaryotes. Cell Res. 2008 Jan; 18(1):174-83.
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Hormone-induced chromosomal instability in p53-null mammary epithelium. Cancer Res. 2004 Aug 15; 64(16):5608-16.
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Damaged DNA and miscounted chromosomes: human T cell leukemia virus type I tax oncoprotein and genetic lesions in transformed cells. J Biomed Sci. 2002 Jul-Aug; 9(4):292-8.
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Mph1, a member of the Mps1-like family of dual specificity protein kinases, is required for the spindle checkpoint in S. pombe. J Cell Sci. 1998 Jun; 111 ( Pt 12):1635-47.
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The Schizosaccharomyces pombe spindle checkpoint protein mad2p blocks anaphase and genetically interacts with the anaphase-promoting complex. Proc Natl Acad Sci U S A. 1997 Jul 22; 94(15):7965-70.