"Securin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Securin is involved in the control of the metaphase-anaphase transition during MITOSIS. It promotes the onset of anaphase by blocking SEPARASE function and preventing proteolysis of cohesin and separation of sister CHROMATIDS. Overexpression of securin is associated with NEOPLASTIC CELL TRANSFORMATION and tumor formation.
| Descriptor ID |
D064249
|
| MeSH Number(s) |
D12.776.167.504
|
| Concept/Terms |
Securin- Securin
- Pituitary Tumor-Transforming Proteins
- Pituitary Tumor Transforming Proteins
- PTTG Protein
- Pituitary Tumor-Transforming Gene Protein
|
Below are MeSH descriptors whose meaning is more general than "Securin".
Below are MeSH descriptors whose meaning is more specific than "Securin".
This graph shows the total number of publications written about "Securin" by people in this website by year, and whether "Securin" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2014 | 1 | 0 | 1 |
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Below are the most recent publications written about "Securin" by people in Profiles.
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ASO Author Reflections: PTTG1 Protein Expression in Adrenocortical Carcinoma. Ann Surg Oncol. 2019 Dec; 26(Suppl 3):533-534.
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Protein Expression of PTTG1 as a Diagnostic Biomarker in Adrenocortical Carcinoma. Ann Surg Oncol. 2018 Mar; 25(3):801-807.
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Pttg1/securin is required for the branching morphogenesis of the mammary gland and suppresses mammary tumorigenesis. Proc Natl Acad Sci U S A. 2014 Jan 21; 111(3):1008-13.
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Coordinated effects of microRNA-494 induce G2/M arrest in human cholangiocarcinoma. Cell Cycle. 2012 Jul 15; 11(14):2729-38.
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Inhibition of pituitary tumor-transforming gene-1 in thyroid cancer cells by drugs that decrease specificity proteins. Mol Carcinog. 2011 Sep; 50(9):655-67.
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Loss of Cdc20 causes a securin-dependent metaphase arrest in two-cell mouse embryos. Mol Cell Biol. 2007 May; 27(9):3481-8.
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Securin and separase phosphorylation act redundantly to maintain sister chromatid cohesion in mammalian cells. Mol Biol Cell. 2005 Oct; 16(10):4725-32.
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Towards genetic genome projects: genomic library screening and gene-targeting vector construction in a single step. Nat Genet. 2002 Jan; 30(1):31-9.
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Control of the DNA damage checkpoint by chk1 and rad53 protein kinases through distinct mechanisms. Science. 1999 Nov 05; 286(5442):1166-71.
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Mitotic arrest: Mad2 prevents sleepy from waking up the APC. Science. 1998 Feb 13; 279(5353):999-1000.