Anaphase-Promoting Complex-Cyclosome
"Anaphase-Promoting Complex-Cyclosome" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An E3 ubiquitin ligase primarily involved in regulation of the metaphase-to-anaphase transition during MITOSIS through ubiquitination of specific CELL CYCLE PROTEINS. Enzyme activity is tightly regulated through subunits and cofactors, which modulate activation, inhibition, and substrate specificity. The anaphase-promoting complex, or APC-C, is also involved in tissue differentiation in the PLACENTA, CRYSTALLINE LENS, and SKELETAL MUSCLE, and in regulation of postmitotic NEURONAL PLASTICITY and excitability.
| Descriptor ID |
D064173
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| MeSH Number(s) |
D08.811.464.938.750.092 D12.776.167.024
|
| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Anaphase-Promoting Complex-Cyclosome".
Below are MeSH descriptors whose meaning is more specific than "Anaphase-Promoting Complex-Cyclosome".
- Anaphase-Promoting Complex-Cyclosome
- Apc1 Subunit, Anaphase-Promoting Complex-Cyclosome
- Apc10 Subunit, Anaphase-Promoting Complex-Cyclosome
- Apc11 Subunit, Anaphase-Promoting Complex-Cyclosome
- Apc2 Subunit, Anaphase-Promoting Complex-Cyclosome
- Apc3 Subunit, Anaphase-Promoting Complex-Cyclosome
- Apc4 Subunit, Anaphase-Promoting Complex-Cyclosome
- Apc5 Subunit, Anaphase-Promoting Complex-Cyclosome
- Apc6 Subunit, Anaphase-Promoting Complex-Cyclosome
- Apc7 Subunit, Anaphase-Promoting Complex-Cyclosome
- Apc8 Subunit, Anaphase-Promoting Complex-Cyclosome
- Cdc20 Proteins
- Cdh1 Proteins
This graph shows the total number of publications written about "Anaphase-Promoting Complex-Cyclosome" by people in this website by year, and whether "Anaphase-Promoting Complex-Cyclosome" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1997 | 0 | 1 | 1 |
| 1999 | 0 | 1 | 1 |
| 2001 | 0 | 1 | 1 |
| 2005 | 0 | 2 | 2 |
| 2006 | 0 | 2 | 2 |
| 2007 | 0 | 2 | 2 |
| 2008 | 0 | 1 | 1 |
| 2010 | 0 | 1 | 1 |
| 2012 | 0 | 1 | 1 |
| 2019 | 1 | 0 | 1 |
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Below are the most recent publications written about "Anaphase-Promoting Complex-Cyclosome" by people in Profiles.
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Mutations in ANAPC1, Encoding a Scaffold Subunit of the Anaphase-Promoting Complex, Cause Rothmund-Thomson Syndrome Type 1. Am J Hum Genet. 2019 09 05; 105(3):625-630.
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Precocious centriole disengagement and centrosome fragmentation induced by mitotic delay. Nat Commun. 2017 06 13; 8:15803.
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Regulation of E2F1 by APC/C Cdh1 via K11 linkage-specific ubiquitin chain formation. Cell Cycle. 2012 May 15; 11(10):2030-8.
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Proliferating cell nuclear antigen (PCNA)-associated KIAA0101/PAF15 protein is a cell cycle-regulated anaphase-promoting complex/cyclosome substrate. Proc Natl Acad Sci U S A. 2011 Jun 14; 108(24):9845-50.
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Nuclear PTEN regulates the APC-CDH1 tumor-suppressive complex in a phosphatase-independent manner. Cell. 2011 Jan 21; 144(2):187-99.
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Pharmacologic inhibition of the anaphase-promoting complex induces a spindle checkpoint-dependent mitotic arrest in the absence of spindle damage. Cancer Cell. 2010 Oct 19; 18(4):382-95.
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The adaptor protein of the anaphase promoting complex Cdh1 is essential in maintaining replicative lifespan and in learning and memory. Nat Cell Biol. 2008 Sep; 10(9):1083-9.
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Emi1 protein accumulation implicates misregulation of the anaphase promoting complex/cyclosome pathway in ovarian clear cell carcinoma. Mod Pathol. 2008 Apr; 21(4):445-54.
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Loss of Emi1-dependent anaphase-promoting complex/cyclosome inhibition deregulates E2F target expression and elicits DNA damage-induced senescence. Mol Cell Biol. 2007 Nov; 27(22):7955-65.
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Oncogenic regulators and substrates of the anaphase promoting complex/cyclosome are frequently overexpressed in malignant tumors. Am J Pathol. 2007 May; 170(5):1793-805.