"Cdc20 Proteins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Highly conserved proteins that specifically bind to and activate the anaphase-promoting complex-cyclosome, promoting ubiquitination and proteolysis of cell-cycle-regulatory proteins. Cdc20 is essential for anaphase-promoting complex activity, initiation of anaphase, and cyclin proteolysis during mitosis.
| Descriptor ID |
D064199
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| MeSH Number(s) |
D08.811.464.938.750.092.998 D12.776.167.024.998
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "Cdc20 Proteins".
Below are MeSH descriptors whose meaning is more specific than "Cdc20 Proteins".
This graph shows the total number of publications written about "Cdc20 Proteins" by people in this website by year, and whether "Cdc20 Proteins" was a major or minor topic of these publications.
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click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2008 | 0 | 1 | 1 |
| 2016 | 0 | 1 | 1 |
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Below are the most recent publications written about "Cdc20 Proteins" by people in Profiles.
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Genomic and Transcriptomic Profiling of Digital Papillary Adenocarcinomas Reveals Alterations in Matrix?Remodeling and Metabolic Genes. J Cutan Pathol. 2025 Apr; 52(4):309-316.
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Prostate cancer-associated mutation in SPOP impairs its ability to target Cdc20 for poly-ubiquitination and degradation. Cancer Lett. 2017 01 28; 385:207-214.
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Histone H3K4 methylation regulates deactivation of the spindle assembly checkpoint through direct binding of Mad2. Genes Dev. 2016 05 15; 30(10):1187-97.
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Driver or passenger effects of augmented c-Myc and Cdc20 in gliomagenesis. Oncotarget. 2016 Apr 26; 7(17):23521-9.
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CDC20 maintains tumor initiating cells. Oncotarget. 2015 May 30; 6(15):13241-54.
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Role of the Mad2 dimerization interface in the spindle assembly checkpoint independent of kinetochores. Curr Biol. 2012 Oct 23; 22(20):1900-8.
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Increased CDC20 expression is associated with pancreatic ductal adenocarcinoma differentiation and progression. J Hematol Oncol. 2012 Apr 04; 5:15.
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Inhibition of gliomagenesis and attenuation of mitotic transition by MIIP. Oncogene. 2010 Jun 17; 29(24):3501-8.
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Aurora A regulates prometaphase progression by inhibiting the ability of RASSF1A to suppress APC-Cdc20 activity. Cancer Res. 2009 Mar 15; 69(6):2314-23.
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Insights into mad2 regulation in the spindle checkpoint revealed by the crystal structure of the symmetric mad2 dimer. PLoS Biol. 2008 Mar 04; 6(3):e50.