Valosin Containing Protein
"Valosin Containing Protein" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A highly-conserved AAA ATPase that functions in the biogenesis of the transitional ENDOPLASMIC RETICULUM and fragmentation and reassembly of the GOLGI APPARATUS during MITOSIS. It also functions in a complex with UFD1L and NPLOC4 proteins to export misfolded ubiquitinated proteins from the endoplasmic reticulum and outer mitochondrial membrane to the cytoplasm for degradation by the PROTEASOME and also plays a role in AUTOPHAGY of ubiquitinated proteins. It occurs in neuronal INCLUSION BODIES from patients with AMYOTROPHIC LATERAL SCLEROSIS and LEWY BODIES from PARKINSON DISEASE patients.
| Descriptor ID |
D000074405
|
| MeSH Number(s) |
D08.811.277.040.013.500.750 D08.811.277.040.025.024.750 D12.776.157.025.750.750 D12.776.167.800
|
| Concept/Terms |
Valosin Containing Protein- Valosin Containing Protein
- Cell Cycle Protein CDC48
- Valosine-Containing Protein
- Valosine Containing Protein
- p97 Valosin-Containing Protein
- Valosin-Containing Protein, p97
- p97 Valosin Containing Protein
- Valosin-Containing Protein
- CDC48 Protein
- Cell Cycle Protein CDC48p
|
Below are MeSH descriptors whose meaning is more general than "Valosin Containing Protein".
Below are MeSH descriptors whose meaning is more specific than "Valosin Containing Protein".
This graph shows the total number of publications written about "Valosin Containing Protein" by people in this website by year, and whether "Valosin Containing Protein" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2008 | 0 | 1 | 1 |
| 2011 | 0 | 1 | 1 |
| 2013 | 0 | 1 | 1 |
| 2014 | 0 | 1 | 1 |
| 2016 | 0 | 1 | 1 |
| 2018 | 1 | 0 | 1 |
| 2023 | 0 | 3 | 3 |
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Below are the most recent publications written about "Valosin Containing Protein" by people in Profiles.
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Analysis of muscle magnetic resonance imaging of a large cohort of patient with VCP-mediated disease reveals characteristic features useful for diagnosis. J Neurol. 2023 Dec; 270(12):5849-5865.
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Valosin-containing protein (VCP/p97) is prognostically unfavorable in pediatric AML, and negatively correlates with unfolded protein response proteins IRE1 and GRP78: A report from the Children's Oncology Group. Proteomics Clin Appl. 2023 11; 17(6):e2200109.
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Provisional practice recommendation for the management of myopathy in VCP-associated multisystem proteinopathy. Ann Clin Transl Neurol. 2023 05; 10(5):686-695.
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Novel valosin-containing protein mutations associated with multisystem proteinopathy. Neuromuscul Disord. 2018 06; 28(6):491-501.
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Pathogenic Mutations in the Valosin-containing Protein/p97(VCP) N-domain Inhibit the SUMOylation of VCP and Lead to Impaired Stress Response. J Biol Chem. 2016 Jul 01; 291(27):14373-14384.
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Interaction of amyotrophic lateral sclerosis/frontotemporal lobar degeneration-associated fused-in-sarcoma with proteins involved in metabolic and protein degradation pathways. Neurobiol Aging. 2015 Jan; 36(1):527-35.
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A tumorigenic factor interactome connected through tumor suppressor microRNA-198 in human pancreatic cancer. Clin Cancer Res. 2013 Nov 01; 19(21):5901-13.
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Pathogenic VCP/TER94 alleles are dominant actives and contribute to neurodegeneration by altering cellular ATP level in a Drosophila IBMPFD model. PLoS Genet. 2011 Feb 03; 7(2):e1001288.
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An Afg2/Spaf-related Cdc48-like AAA ATPase regulates the stability and activity of the C. elegans Aurora B kinase AIR-2. Dev Cell. 2008 Oct; 15(4):603-16.