Tumor Necrosis Factor alpha-Induced Protein 3
"Tumor Necrosis Factor alpha-Induced Protein 3" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A UBIQUITIN editing enzyme that functions as both a ubiquitin ligase and deubiquitinase. It contains several ZINC FINGERS and functions in the immune response and INFLAMMATION by modulating signals from TNF-ALPHA; IL1-BETA; or pathogens via TOLL-LIKE RECEPTORS to terminate NF-KAPPA B activity.
| Descriptor ID |
D000072598
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| MeSH Number(s) |
D08.811.037.750.500 D08.811.277.656.300.887.750 D08.811.464.938.750.813 D12.644.360.950 D12.776.476.938
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Tumor Necrosis Factor alpha-Induced Protein 3".
Below are MeSH descriptors whose meaning is more specific than "Tumor Necrosis Factor alpha-Induced Protein 3".
This graph shows the total number of publications written about "Tumor Necrosis Factor alpha-Induced Protein 3" by people in this website by year, and whether "Tumor Necrosis Factor alpha-Induced Protein 3" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2008 | 0 | 1 | 1 |
| 2011 | 0 | 1 | 1 |
| 2016 | 0 | 1 | 1 |
| 2021 | 1 | 1 | 2 |
| 2022 | 1 | 0 | 1 |
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Below are the most recent publications written about "Tumor Necrosis Factor alpha-Induced Protein 3" by people in Profiles.
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YAP9/A20 complex suppresses proinflammatory responses and provides novel anti-inflammatory therapeutic potentials. Front Immunol. 2022; 13:914381.
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A novel missense mutation in TNFAIP3 causes haploinsufficiency of A20. Cell Immunol. 2022 01; 371:104453.
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Complicated Diagnosis and Treatment of HA20 due to Contiguous Gene Deletions involving 6q23.3. J Clin Immunol. 2021 08; 41(6):1420-1423.
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Adaptive response to inflammation contributes to sustained myelopoiesis and confers a competitive advantage in myelodysplastic syndrome HSCs. Nat Immunol. 2020 05; 21(5):535-545.
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A20 restricts inflammation via ubiquitin binding. Nat Immunol. 2020 04; 21(4):362-364.
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E-cadherin expression on multiple myeloma cells activates tumor-promoting properties in plasmacytoid DCs. J Clin Invest. 2018 11 01; 128(11):4821-4831.
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Identification of an Association of TNFAIP3 Polymorphisms With Matrix Metalloproteinase Expression in Fibroblasts in an Integrative Study of Systemic Sclerosis-Associated Genetic and Environmental Factors. Arthritis Rheumatol. 2016 Mar; 68(3):749-60.
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Mucosal and systemic anti-HIV immunity controlled by A20 in mouse dendritic cells. J Clin Invest. 2011 Feb; 121(2):739-51.
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Most common single-nucleotide polymorphisms associated with rheumatoid arthritis in persons of European ancestry confer risk of rheumatoid arthritis in African Americans. Arthritis Rheum. 2010 Dec; 62(12):3547-53.
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CYLD: a tumor suppressor deubiquitinase regulating NF-kappaB activation and diverse biological processes. Cell Death Differ. 2010 Jan; 17(1):25-34.