"COP9 Signalosome Complex" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A multiprotein complex that functions as a peptide hydrolase, or isopeptidase to cleave NEDD8 PROTEIN from the CULLIN and UBIQUITIN-PROTEIN LIGASES, controlling the activity of the ligases. It is highly conserved in eukaryotes and typically consists of 8 subunits (CSN 1-8 proteins). The COP9 signalosome was originally identified in plants, where it controls gene transcription in response to light.
| Descriptor ID |
D000075686
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| MeSH Number(s) |
D05.500.139 D08.811.037.750.250 D08.811.277.656.300.887.375
|
| Concept/Terms |
COP9 Signalosome Complex- COP9 Signalosome Complex
- Signalosome Complex, COP9
- Constitutive Photomorphogenesis 9 Signalsome
- COP9 Signalsome
- Signalsome, COP9
- Constitutive Photomorphogenesis 9 Signalosome
- COP9 Signalosome (CSN)
|
Below are MeSH descriptors whose meaning is more general than "COP9 Signalosome Complex".
Below are MeSH descriptors whose meaning is more specific than "COP9 Signalosome Complex".
This graph shows the total number of publications written about "COP9 Signalosome Complex" by people in this website by year, and whether "COP9 Signalosome Complex" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1999 | 0 | 2 | 2 |
| 2000 | 0 | 1 | 1 |
| 2003 | 0 | 1 | 1 |
| 2004 | 0 | 1 | 1 |
| 2011 | 0 | 2 | 2 |
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Below are the most recent publications written about "COP9 Signalosome Complex" by people in Profiles.
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Differences in blastomere totipotency in 2-cell mouse embryos are a maternal trait mediated by asymmetric mRNA distribution. Mol Hum Reprod. 2019 11 30; 25(11):729-744.
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MicroRNA-17 acts as a tumor chemosensitizer by targeting JAB1/CSN5 in triple-negative breast cancer. Cancer Lett. 2019 11 28; 465:12-23.
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The novel Jab1 inhibitor CSN5i-3 suppresses cell proliferation and induces apoptosis in human breast cancer cells. Neoplasma. 2019 May 23; 66(3):481-486.
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Jab1/Cops5 contributes to chemoresistance in breast cancer by regulating Rad51. Cell Signal. 2019 01; 53:39-48.
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Jab1/Csn5-Thioredoxin Signaling in Relapsed Acute Monocytic Leukemia under Oxidative Stress. Clin Cancer Res. 2017 Aug 01; 23(15):4450-4461.
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Deubiquitination and Stabilization of PD-L1 by CSN5. Cancer Cell. 2016 Dec 12; 30(6):925-939.
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Stat3 contributes to cancer progression by regulating Jab1/Csn5 expression. Oncogene. 2017 02 23; 36(8):1069-1079.
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Role of Myeloma-Derived MIF in Myeloma Cell Adhesion to Bone Marrow and Chemotherapy Response. J Natl Cancer Inst. 2016 11; 108(11).
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Hsa-miR-24-3p increases nasopharyngeal carcinoma radiosensitivity by targeting both the 3'UTR and 5'UTR of Jab1/CSN5. Oncogene. 2016 11 24; 35(47):6096-6108.
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Down-regulation of the cyclin-dependent kinase inhibitor p57 is mediated by Jab1/Csn5 in hepatocarcinogenesis. Hepatology. 2016 Mar; 63(3):898-913.