"COP9 Signalosome Complex" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A multiprotein complex that functions as a peptide hydrolase, or isopeptidase to cleave NEDD8 PROTEIN from the CULLIN and UBIQUITIN-PROTEIN LIGASES, controlling the activity of the ligases. It is highly conserved in eukaryotes and typically consists of 8 subunits (CSN 1-8 proteins). The COP9 signalosome was originally identified in plants, where it controls gene transcription in response to light.
| Descriptor ID |
D000075686
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| MeSH Number(s) |
D05.500.139 D08.811.037.750.250 D08.811.277.656.300.887.375
|
| Concept/Terms |
COP9 Signalosome Complex- COP9 Signalosome Complex
- Signalosome Complex, COP9
- Constitutive Photomorphogenesis 9 Signalsome
- COP9 Signalsome
- Signalsome, COP9
- Constitutive Photomorphogenesis 9 Signalosome
- COP9 Signalosome (CSN)
|
Below are MeSH descriptors whose meaning is more general than "COP9 Signalosome Complex".
Below are MeSH descriptors whose meaning is more specific than "COP9 Signalosome Complex".
This graph shows the total number of publications written about "COP9 Signalosome Complex" by people in this website by year, and whether "COP9 Signalosome Complex" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1999 | 0 | 2 | 2 |
| 2000 | 0 | 1 | 1 |
| 2003 | 0 | 2 | 2 |
| 2004 | 0 | 2 | 2 |
| 2011 | 0 | 2 | 2 |
| 2016 | 0 | 1 | 1 |
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Below are the most recent publications written about "COP9 Signalosome Complex" by people in Profiles.
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ERK2-Dependent Phosphorylation of CSN6 Is Critical in Colorectal Cancer Development. Cancer Cell. 2015 Aug 10; 28(2):183-97.
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CSN6 drives carcinogenesis by positively regulating Myc stability. Nat Commun. 2014 Nov 14; 5:5384.
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HER2-Akt signaling in regulating COP9 signalsome subunit 6 and p53. Cell Cycle. 2012 Nov 15; 11(22):4181-90.
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COP9 signalosome subunit 6 stabilizes COP1, which functions as an E3 ubiquitin ligase for 14-3-3s. Oncogene. 2011 Dec 01; 30(48):4791-801.
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Subunit 6 of the COP9 signalosome promotes tumorigenesis in mice through stabilization of MDM2 and is upregulated in human cancers. J Clin Invest. 2011 Mar; 121(3):851-65.
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Essential roles of Jab1 in cell survival, spontaneous DNA damage and DNA repair. Oncogene. 2010 Nov 18; 29(46):6125-37.
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Roles for CSN5 in control of p53/MDM2 activities. J Cell Biochem. 2008 Mar 01; 103(4):1219-30.
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Potential role of Jun activation domain-binding protein 1 as a negative regulator of p27kip1 in pancreatic adenocarcinoma. Cancer Res. 2006 Sep 01; 66(17):8581-9.
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Modified p27 Kip1 is efficient in suppressing HER2-mediated tumorigenicity. J Cell Biochem. 2006 May 01; 98(1):128-38.
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The S100A7-c-Jun activation domain binding protein 1 pathway enhances prosurvival pathways in breast cancer. Cancer Res. 2005 Jul 01; 65(13):5696-702.