"Apoptosomes" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Multimeric protein complexes formed in the CYTOSOL that play a role in the activation of APOPTOSIS. They can occur when MITOCHONDRIA become damaged due to cell stress and release CYTOCHROME C. Cytosolic cytochrome C associates with APOPTOTIC PROTEASE-ACTIVATING FACTOR 1 to form the apoptosomal protein complex. The apoptosome signals apoptosis by binding to and activating specific INITIATOR CASPASES such as CASPASE 9.
| Descriptor ID |
D053478
|
| MeSH Number(s) |
D05.500.099
|
| Concept/Terms |
Apoptosomes- Apoptosomes
- Apoptosome
- Apoptosomal Protein Complex
- Complex, Apoptosomal Protein
- Protein Complex, Apoptosomal
|
Below are MeSH descriptors whose meaning is more general than "Apoptosomes".
Below are MeSH descriptors whose meaning is more specific than "Apoptosomes".
This graph shows the total number of publications written about "Apoptosomes" by people in this website by year, and whether "Apoptosomes" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2007 | 2 | 1 | 3 |
| 2009 | 1 | 0 | 1 |
| 2010 | 2 | 0 | 2 |
| 2011 | 4 | 0 | 4 |
| 2016 | 1 | 1 | 2 |
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Below are the most recent publications written about "Apoptosomes" by people in Profiles.
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A Near-Atomic Structure of the Dark Apoptosome Provides Insight into Assembly and Activation. Structure. 2017 01 03; 25(1):40-52.
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The Apaf-1 apoptosome induces formation of caspase-9 homo- and heterodimers with distinct activities. Nat Commun. 2016 11 24; 7:13565.
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The holo-apoptosome: activation of procaspase-9 and interactions with caspase-3. Structure. 2011 Aug 10; 19(8):1084-96.
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The frequency of 1,4-benzoquinone-lysine adducts in cytochrome c correlate with defects in apoptosome activation. Toxicol Sci. 2011 Jul; 122(1):64-72.
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Defective molecular timer in the absence of nucleotides leads to inefficient caspase activation. PLoS One. 2011 Jan 27; 6(1):e16379.
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Structure of the Drosophila apoptosome at 6.9?? resolution. Structure. 2011 Jan 12; 19(1):128-40.
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Regulation of the Apaf-1-caspase-9 apoptosome. J Cell Sci. 2010 Oct 01; 123(Pt 19):3209-14.
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Structure of an apoptosome-procaspase-9 CARD complex. Structure. 2010 May 12; 18(5):571-83.
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The Apaf-1*procaspase-9 apoptosome complex functions as a proteolytic-based molecular timer. EMBO J. 2009 Jul 08; 28(13):1916-25.
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Quinone electrophiles selectively adduct "electrophile binding motifs" within cytochrome c. Biochemistry. 2007 Oct 02; 46(39):11090-100.