Ubiquitin-Specific Peptidase 7
"Ubiquitin-Specific Peptidase 7" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A ubiquitinyl hydrolase that deubiquitinates several proteins with critical roles in DNA REPAIR, cell growth, and survival, including TUMOR SUPPRESSOR PROTEIN P53; MDM-2 PROTEIN; and PTEN PHOSPHOHYDROLASE. It also stabilizes herpesvirus 1 trans-acting transcriptional protein VMW110 during HSV-1 infection, contributing to its function as a TRANS-ACTIVATOR.
| Descriptor ID |
D000076084
|
| MeSH Number(s) |
D08.811.037.500.500 D08.811.037.750.750 D08.811.277.352.897.850.500 D08.811.277.656.300.887.875
|
| Concept/Terms |
Ubiquitin-Specific Peptidase 7- Ubiquitin-Specific Peptidase 7
- Peptidase 7, Ubiquitin-Specific
- Ubiquitin Specific Peptidase 7
- HAUSP Protein
- Herpesvirus-Associated Ubiquitin-Specific Peptidase
- Herpesvirus Associated Ubiquitin Specific Peptidase
- Peptidase, Herpesvirus-Associated Ubiquitin-Specific
- Ubiquitin-Specific Peptidase, Herpesvirus-Associated
- USP7 Protein
|
Below are MeSH descriptors whose meaning is more general than "Ubiquitin-Specific Peptidase 7".
Below are MeSH descriptors whose meaning is more specific than "Ubiquitin-Specific Peptidase 7".
This graph shows the total number of publications written about "Ubiquitin-Specific Peptidase 7" by people in this website by year, and whether "Ubiquitin-Specific Peptidase 7" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2006 | 0 | 1 | 1 |
| 2007 | 0 | 1 | 1 |
| 2008 | 0 | 2 | 2 |
| 2011 | 0 | 1 | 1 |
| 2012 | 0 | 2 | 2 |
| 2013 | 0 | 2 | 2 |
| 2014 | 0 | 1 | 1 |
| 2018 | 1 | 0 | 1 |
| 2019 | 1 | 0 | 1 |
| 2022 | 0 | 2 | 2 |
| 2023 | 0 | 1 | 1 |
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Below are the most recent publications written about "Ubiquitin-Specific Peptidase 7" by people in Profiles.
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Evolutionarily conserved regulators of tau identify targets for new therapies. Neuron. 2023 03 15; 111(6):824-838.e7.
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USP7 substrates identified by proteomics analysis reveal the specificity of USP7. Genes Dev. 2022 09 01; 36(17-18):1016-1030.
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p16 Represses DNA Damage Repair via a Novel Ubiquitin-Dependent Signaling Cascade. Cancer Res. 2022 03 01; 82(5):916-928.
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Response to Briuglia et al. Genet Med. 2021 02; 23(2):423-424.
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Genome-Wide Association Study of Susceptibility Loci for T-Cell Acute Lymphoblastic Leukemia in Children. J Natl Cancer Inst. 2019 12 01; 111(12):1350-1357.
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Targeting USP7 Identifies a Metastasis-Competent State within Bone Marrow-Resident Melanoma CTCs. Cancer Res. 2018 09 15; 78(18):5349-5362.
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USP7 Acts as a Molecular Rheostat to Promote WASH-Dependent Endosomal Protein Recycling and Is Mutated in a Human Neurodevelopmental Disorder. Mol Cell. 2015 Sep 17; 59(6):956-69.
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ATM-mediated stabilization of ZEB1 promotes DNA damage response and radioresistance through CHK1. Nat Cell Biol. 2014 Sep; 16(9):864-75.
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USP7 inhibitor P22077 inhibits neuroblastoma growth via inducing p53-mediated apoptosis. Cell Death Dis. 2013 Oct 17; 4:e867.
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SRC-3 coactivator regulates cell resistance to cytotoxic stress via TRAF4-mediated p53 destabilization. Genes Dev. 2013 Feb 01; 27(3):274-87.