Ubiquitin-Specific Proteases
"Ubiquitin-Specific Proteases" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Members of the peptidase C19 family which regulate signal transduction by removing UBIQUITIN from specific protein substrates via a process known as deubiquitination or deubiquitylation.
| Descriptor ID |
D064570
|
| MeSH Number(s) |
D08.811.037.750 D08.811.277.656.300.887
|
| Concept/Terms |
Ubiquitin-Specific Proteases- Ubiquitin-Specific Proteases
- Proteases, Ubiquitin-Specific
- Ubiquitin Specific Proteases
- Ubiquitin-Specific Peptidases
- Peptidases, Ubiquitin-Specific
- Ubiquitin Specific Peptidases
- Ubiquitin-Specific Protease Family
- Protease Family, Ubiquitin-Specific
- Ubiquitin Specific Protease Family
|
Below are MeSH descriptors whose meaning is more general than "Ubiquitin-Specific Proteases".
Below are MeSH descriptors whose meaning is more specific than "Ubiquitin-Specific Proteases".
This graph shows the total number of publications written about "Ubiquitin-Specific Proteases" by people in this website by year, and whether "Ubiquitin-Specific Proteases" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2006 | 0 | 1 | 1 |
| 2007 | 0 | 1 | 1 |
| 2008 | 0 | 1 | 1 |
| 2010 | 0 | 1 | 1 |
| 2011 | 0 | 2 | 2 |
| 2012 | 0 | 1 | 1 |
| 2013 | 1 | 3 | 4 |
| 2014 | 3 | 1 | 4 |
| 2015 | 3 | 0 | 3 |
| 2016 | 2 | 1 | 3 |
| 2017 | 1 | 1 | 2 |
| 2018 | 5 | 0 | 5 |
| 2019 | 1 | 0 | 1 |
| 2021 | 1 | 1 | 2 |
| 2022 | 0 | 2 | 2 |
| 2023 | 1 | 0 | 1 |
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Below are the most recent publications written about "Ubiquitin-Specific Proteases" by people in Profiles.
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USP1 promotes cholangiocarcinoma progression by deubiquitinating PARP1 to prevent its proteasomal degradation. Cell Death Dis. 2023 10 11; 14(10):669.
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Loss of ubiquitin-specific peptidase 18 destabilizes 14-3-3? protein and represses lung cancer metastasis. Cancer Biol Ther. 2022 12 31; 23(1):265-280.
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Regulation of Cyclin D1 Degradation by Ubiquitin-Specific Protease 27X Is Critical for Cancer Cell Proliferation and Tumor Growth. Mol Cancer Res. 2022 12 02; 20(12):1751-1762.
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Clonal Hematopoiesis Mutations in Patients with Lung Cancer Are Associated with Lung Cancer Risk Factors. Cancer Res. 2022 01 15; 82(2):199-209.
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Non-canonical function of DGCR8 in DNA double-strand break repair signaling and tumor radioresistance. Nat Commun. 2021 06 29; 12(1):4033.
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Biallelic loss-of-function P4HTM gene variants cause hypotonia, hypoventilation, intellectual disability, dysautonomia, epilepsy, and eye abnormalities (HIDEA syndrome). Genet Med. 2019 10; 21(10):2355-2363.
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Aberrant Activation of ?-Catenin Signaling Drives Glioma Tumorigenesis via USP1-Mediated Stabilization of EZH2. Cancer Res. 2019 01 01; 79(1):72-85.
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TGF?-Activated USP27X Deubiquitinase Regulates Cell Migration and Chemoresistance via Stabilization of Snail1. Cancer Res. 2019 01 01; 79(1):33-46.
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SKP2- and OTUD1-regulated non-proteolytic ubiquitination of YAP promotes YAP nuclear localization and activity. Nat Commun. 2018 06 11; 9(1):2269.
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C-Terminal End-Directed Protein Elimination by CRL2?Ubiquitin Ligases. Mol Cell. 2018 05 17; 70(4):602-613.e3.