Ubiquitin-Specific Proteases
"Ubiquitin-Specific Proteases" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Members of the peptidase C19 family which regulate signal transduction by removing UBIQUITIN from specific protein substrates via a process known as deubiquitination or deubiquitylation.
| Descriptor ID |
D064570
|
| MeSH Number(s) |
D08.811.037.750 D08.811.277.656.300.887
|
| Concept/Terms |
Ubiquitin-Specific Proteases- Ubiquitin-Specific Proteases
- Proteases, Ubiquitin-Specific
- Ubiquitin Specific Proteases
- Ubiquitin-Specific Peptidases
- Peptidases, Ubiquitin-Specific
- Ubiquitin Specific Peptidases
- Ubiquitin-Specific Protease Family
- Protease Family, Ubiquitin-Specific
- Ubiquitin Specific Protease Family
|
Below are MeSH descriptors whose meaning is more general than "Ubiquitin-Specific Proteases".
Below are MeSH descriptors whose meaning is more specific than "Ubiquitin-Specific Proteases".
This graph shows the total number of publications written about "Ubiquitin-Specific Proteases" by people in this website by year, and whether "Ubiquitin-Specific Proteases" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2006 | 0 | 1 | 1 |
| 2007 | 0 | 1 | 1 |
| 2010 | 0 | 1 | 1 |
| 2013 | 1 | 2 | 3 |
| 2014 | 1 | 1 | 2 |
| 2016 | 1 | 0 | 1 |
| 2018 | 1 | 0 | 1 |
| 2019 | 1 | 0 | 1 |
| 2021 | 0 | 1 | 1 |
| 2022 | 0 | 1 | 1 |
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Below are the most recent publications written about "Ubiquitin-Specific Proteases" by people in Profiles.
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Therapeutic targeting of the USP2-E2F4 axis inhibits autophagic machinery essential for zinc homeostasis in cancer progression. Autophagy. 2022 11; 18(11):2615-2635.
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Clonal Hematopoiesis Mutations in Patients with Lung Cancer Are Associated with Lung Cancer Risk Factors. Cancer Res. 2022 01 15; 82(2):199-209.
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Biallelic loss-of-function P4HTM gene variants cause hypotonia, hypoventilation, intellectual disability, dysautonomia, epilepsy, and eye abnormalities (HIDEA syndrome). Genet Med. 2019 10; 21(10):2355-2363.
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USP15-dependent lysosomal pathway controls p53-R175H turnover in ovarian cancer cells. Nat Commun. 2018 03 28; 9(1):1270.
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PDGF Engages an E2F-USP1 Signaling Pathway to Support ID2-Mediated Survival of Proneural Glioma Cells. Cancer Res. 2016 05 15; 76(10):2964-76.
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Higher-Order Assembly of BRCC36-KIAA0157 Is Required for DUB Activity and Biological Function. Mol Cell. 2015 Sep 17; 59(6):970-83.
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A fragment-based method to discover irreversible covalent inhibitors of cysteine proteases. J Med Chem. 2014 Jun 12; 57(11):4969-74.
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USP15 stabilizes MDM2 to mediate cancer-cell survival and inhibit antitumor T cell responses. Nat Immunol. 2014 Jun; 15(6):562-70.
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USP21 negatively regulates antiviral response by acting as a RIG-I deubiquitinase. J Exp Med. 2014 Feb 10; 211(2):313-28.
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Deubiquitylation and stabilization of PTEN by USP13. Nat Cell Biol. 2013 Dec; 15(12):1486-1494.