Deubiquitinating Enzyme CYLD
"Deubiquitinating Enzyme CYLD" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A deubiquitinase and tumor-suppressor protein that specifically cleaves LYSINE-63-linked polyubiquitin chains and also has endodeubiquitinase activity. It functions to regulate NF-KAPPA B and WNT SIGNALING PATHWAY activity, contributing to cell survival, proliferation, and differentiation. Mutations in the CYLD gene are associated with cases of FAMILIAL CYLINDROMATOSIS.
| Descriptor ID |
D000074749
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| MeSH Number(s) |
D08.811.037.375 D12.776.624.776.482
|
| Concept/Terms |
Deubiquitinating Enzyme CYLD- Deubiquitinating Enzyme CYLD
- CYLD, Deubiquitinating Enzyme
- Cylindromatosis Protein
- Deubiquitinating Enzyme Cylindromatosis
- Cylindromatosis, Deubiquitinating Enzyme
- CYLD Protein
|
Below are MeSH descriptors whose meaning is more general than "Deubiquitinating Enzyme CYLD".
Below are MeSH descriptors whose meaning is more specific than "Deubiquitinating Enzyme CYLD".
This graph shows the total number of publications written about "Deubiquitinating Enzyme CYLD" by people in this website by year, and whether "Deubiquitinating Enzyme CYLD" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2006 | 0 | 1 | 1 |
| 2013 | 0 | 1 | 1 |
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Below are the most recent publications written about "Deubiquitinating Enzyme CYLD" by people in Profiles.
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CRISPR-based gene knockout screens reveal deubiquitinases involved in HIV-1 latency in two Jurkat cell models. Sci Rep. 2020 03 24; 10(1):5350.
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Frequent and differential mutations of the CYLD gene in basal cell salivary neoplasms: linkage to tumor development and progression. Mod Pathol. 2018 07; 31(7):1064-1072.
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The deubiquitinating enzyme cylindromatosis mitigates nonalcoholic steatohepatitis. Nat Med. 2018 02; 24(2):213-223.
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High LEF1 expression predicts adverse prognosis in chronic lymphocytic leukemia and may be targeted by ethacrynic acid. Oncotarget. 2016 Apr 19; 7(16):21631-43.
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Cycles of ubiquitination and deubiquitination critically regulate growth factor-mediated activation of Akt signaling. Sci Signal. 2013 Jan 08; 6(257):ra3.
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Regulation of antiviral innate immunity by deubiquitinase CYLD. Cell Mol Immunol. 2011 Nov; 8(6):502-4.
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The Notch/Hes1 pathway sustains NF-?B activation through CYLD repression in T cell leukemia. Cancer Cell. 2010 Sep 14; 18(3):268-81.
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CARMA1 regulation of regulatory T cell development involves modulation of interleukin-2 receptor signaling. J Biol Chem. 2010 May 21; 285(21):15696-703.
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Regulation of natural killer T-cell development by deubiquitinase CYLD. EMBO J. 2010 May 05; 29(9):1600-12.
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CYLD: a tumor suppressor deubiquitinase regulating NF-kappaB activation and diverse biological processes. Cell Death Differ. 2010 Jan; 17(1):25-34.