Deubiquitinating Enzyme CYLD
"Deubiquitinating Enzyme CYLD" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A deubiquitinase and tumor-suppressor protein that specifically cleaves LYSINE-63-linked polyubiquitin chains and also has endodeubiquitinase activity. It functions to regulate NF-KAPPA B and WNT SIGNALING PATHWAY activity, contributing to cell survival, proliferation, and differentiation. Mutations in the CYLD gene are associated with cases of FAMILIAL CYLINDROMATOSIS.
| Descriptor ID |
D000074749
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| MeSH Number(s) |
D08.811.037.375 D12.776.624.776.482
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| Concept/Terms |
Deubiquitinating Enzyme CYLD- Deubiquitinating Enzyme CYLD
- CYLD, Deubiquitinating Enzyme
- Cylindromatosis Protein
- Deubiquitinating Enzyme Cylindromatosis
- Cylindromatosis, Deubiquitinating Enzyme
- CYLD Protein
|
Below are MeSH descriptors whose meaning is more general than "Deubiquitinating Enzyme CYLD".
Below are MeSH descriptors whose meaning is more specific than "Deubiquitinating Enzyme CYLD".
This graph shows the total number of publications written about "Deubiquitinating Enzyme CYLD" by people in this website by year, and whether "Deubiquitinating Enzyme CYLD" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2006 | 0 | 1 | 1 |
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Below are the most recent publications written about "Deubiquitinating Enzyme CYLD" by people in Profiles.
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The Notch/Hes1 pathway sustains NF-?B activation through CYLD repression in T cell leukemia. Cancer Cell. 2010 Sep 14; 18(3):268-81.
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CARMA1 regulation of regulatory T cell development involves modulation of interleukin-2 receptor signaling. J Biol Chem. 2010 May 21; 285(21):15696-703.
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Regulation of natural killer T-cell development by deubiquitinase CYLD. EMBO J. 2010 May 05; 29(9):1600-12.
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Regulation of IkappaB kinase-related kinases and antiviral responses by tumor suppressor CYLD. J Biol Chem. 2008 Jul 04; 283(27):18621-6.
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Regulation of early wave of germ cell apoptosis and spermatogenesis by deubiquitinating enzyme CYLD. Dev Cell. 2007 Nov; 13(5):705-716.
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Frequent engagement of the classical and alternative NF-kappaB pathways by diverse genetic abnormalities in multiple myeloma. Cancer Cell. 2007 Aug; 12(2):115-30.
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Deubiquitinating enzyme CYLD negatively regulates the ubiquitin-dependent kinase Tak1 and prevents abnormal T cell responses. J Exp Med. 2007 Jun 11; 204(6):1475-85.
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Deubiquitinating enzyme CYLD regulates the peripheral development and naive phenotype maintenance of B cells. J Biol Chem. 2007 May 25; 282(21):15884-93.
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CYLD mutations underlie Brooke-Spiegler, familial cylindromatosis, and multiple familial trichoepithelioma syndromes. Clin Genet. 2006 Sep; 70(3):246-9.
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Regulation of the deubiquitinating enzyme CYLD by IkappaB kinase gamma-dependent phosphorylation. Mol Cell Biol. 2005 May; 25(10):3886-95.