"Retinoblastoma Protein" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Product of the retinoblastoma tumor suppressor gene. It is a nuclear phosphoprotein hypothesized to normally act as an inhibitor of cell proliferation. Rb protein is absent in retinoblastoma cell lines. It also has been shown to form complexes with the adenovirus E1A protein, the SV40 T antigen, and the human papilloma virus E7 protein.
| Descriptor ID |
D016160
|
| MeSH Number(s) |
D12.776.260.704 D12.776.624.776.745 D12.776.660.807 D12.776.744.770
|
| Concept/Terms |
p105-Rb Protein- p105-Rb Protein
- p105 Rb Protein
- Retinoblastoma Nuclear Phosphoprotein p105-Rb
- Retinoblastoma Nuclear Phosphoprotein p105 Rb
|
Below are MeSH descriptors whose meaning is more general than "Retinoblastoma Protein".
Below are MeSH descriptors whose meaning is more specific than "Retinoblastoma Protein".
This graph shows the total number of publications written about "Retinoblastoma Protein" by people in this website by year, and whether "Retinoblastoma Protein" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1995 | 3 | 5 | 8 |
| 1996 | 1 | 2 | 3 |
| 1997 | 7 | 3 | 10 |
| 1998 | 4 | 15 | 19 |
| 1999 | 8 | 7 | 15 |
| 2000 | 4 | 4 | 8 |
| 2001 | 5 | 10 | 15 |
| 2002 | 1 | 4 | 5 |
| 2003 | 5 | 7 | 12 |
| 2004 | 4 | 5 | 9 |
| 2005 | 4 | 6 | 10 |
| 2006 | 4 | 5 | 9 |
| 2007 | 9 | 3 | 12 |
| 2008 | 1 | 3 | 4 |
| 2009 | 4 | 5 | 9 |
| 2010 | 5 | 4 | 9 |
| 2011 | 4 | 5 | 9 |
| 2012 | 0 | 6 | 6 |
| 2013 | 2 | 5 | 7 |
| 2014 | 1 | 1 | 2 |
| 2015 | 2 | 3 | 5 |
| 2016 | 1 | 2 | 3 |
| 2017 | 4 | 1 | 5 |
| 2018 | 0 | 1 | 1 |
| 2019 | 0 | 1 | 1 |
| 2020 | 1 | 1 | 2 |
| 2022 | 0 | 1 | 1 |
| 2023 | 0 | 1 | 1 |
| 2024 | 0 | 1 | 1 |
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Below are the most recent publications written about "Retinoblastoma Protein" by people in Profiles.
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Integrative Multiomic Profiling of Triple-Negative Breast Cancer for Identifying Suitable Therapies. Clin Cancer Res. 2024 Oct 15; 30(20):4768-4779.
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Sequential Targeting of Retinoblastoma and DNA Synthesis Pathways Is a Therapeutic Strategy for Sarcomas That Can Be Monitored in Real Time. Cancer Res. 2023 03 15; 83(6):939-955.
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Combined TRIP13 and Aurora Kinase Inhibition Induces Apoptosis in Human Papillomavirus-Driven Cancers. Clin Cancer Res. 2022 10 14; 28(20):4479-4493.
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Proteogenomic Landscape of Breast Cancer Tumorigenesis and Targeted Therapy. Cell. 2020 11 25; 183(5):1436-1456.e31.
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The E2F1 transcription factor and RB tumor suppressor moonlight as DNA repair factors. Cell Cycle. 2020 09; 19(18):2260-2269.
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Proteogenomic Analysis of Human Colon Cancer Reveals New Therapeutic Opportunities. Cell. 2019 05 02; 177(4):1035-1049.e19.
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Cooperative p16 and p21 action protects female astrocytes from transformation. Acta Neuropathol Commun. 2018 02 20; 6(1):12.
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Reduced Retinoblastoma Protein Expression Is Associated with Decreased Patient Survival in Medullary Thyroid Cancer. Thyroid. 2017 12; 27(12):1523-1533.
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Surviving Ovarian Cancer: An Affair between Defective DNA Repair and RB1. Clin Cancer Res. 2018 02 01; 24(3):508-510.
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Tudor-domain protein PHF20L1 reads lysine methylated retinoblastoma tumour suppressor protein. Cell Death Differ. 2017 12; 24(12):2139-2149.