"Retinoblastoma Protein" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Product of the retinoblastoma tumor suppressor gene. It is a nuclear phosphoprotein hypothesized to normally act as an inhibitor of cell proliferation. Rb protein is absent in retinoblastoma cell lines. It also has been shown to form complexes with the adenovirus E1A protein, the SV40 T antigen, and the human papilloma virus E7 protein.
| Descriptor ID |
D016160
|
| MeSH Number(s) |
D12.776.260.704 D12.776.624.776.745 D12.776.660.807 D12.776.744.770
|
| Concept/Terms |
p105-Rb Protein- p105-Rb Protein
- p105 Rb Protein
- Retinoblastoma Nuclear Phosphoprotein p105-Rb
- Retinoblastoma Nuclear Phosphoprotein p105 Rb
|
Below are MeSH descriptors whose meaning is more general than "Retinoblastoma Protein".
Below are MeSH descriptors whose meaning is more specific than "Retinoblastoma Protein".
This graph shows the total number of publications written about "Retinoblastoma Protein" by people in this website by year, and whether "Retinoblastoma Protein" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1996 | 1 | 0 | 1 |
| 1998 | 0 | 1 | 1 |
| 1999 | 1 | 0 | 1 |
| 2000 | 0 | 1 | 1 |
| 2001 | 2 | 2 | 4 |
| 2002 | 0 | 1 | 1 |
| 2003 | 1 | 3 | 4 |
| 2004 | 3 | 2 | 5 |
| 2005 | 1 | 1 | 2 |
| 2006 | 2 | 1 | 3 |
| 2007 | 2 | 0 | 2 |
| 2008 | 0 | 3 | 3 |
| 2009 | 2 | 3 | 5 |
| 2010 | 2 | 1 | 3 |
| 2011 | 2 | 1 | 3 |
| 2012 | 0 | 2 | 2 |
| 2013 | 1 | 3 | 4 |
| 2014 | 1 | 0 | 1 |
| 2015 | 0 | 2 | 2 |
| 2017 | 1 | 0 | 1 |
| 2018 | 1 | 1 | 2 |
| 2019 | 0 | 1 | 1 |
| 2020 | 0 | 1 | 1 |
| 2022 | 0 | 2 | 2 |
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Below are the most recent publications written about "Retinoblastoma Protein" by people in Profiles.
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Frequent mutation of the major cartilage collagen gene COL2A1 in chondrosarcoma. Nat Genet. 2013 Aug; 45(8):923-6.
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Staurosporine is chemoprotective by inducing G1 arrest in a Chk1- and pRb-dependent manner. Carcinogenesis. 2013 Oct; 34(10):2244-52.
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The complex containing Drosophila Myb and RB/E2F2 regulates cytokinesis in a histone H2Av-dependent manner. Mol Cell Biol. 2013 May; 33(9):1809-18.
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Hepatocyte-specific deletion of farnesoid X receptor delays but does not inhibit liver regeneration after partial hepatectomy in mice. Hepatology. 2012 Dec; 56(6):2344-52.
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Comprehensive molecular portraits of human breast tumours. Nature. 2012 Oct 04; 490(7418):61-70.
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p53 negatively regulates Aurora A via both transcriptional and posttranslational regulation. Cell Cycle. 2012 Sep 15; 11(18):3433-42.
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The p44/wdr77-dependent cellular proliferation process during lung development is reactivated in lung cancer. Oncogene. 2013 Apr 11; 32(15):1888-900.
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Therapeutically activating RB: reestablishing cell cycle control in endocrine therapy-resistant breast cancer. Endocr Relat Cancer. 2011 Jun; 18(3):333-45.
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Demethylation of RB regulator MYPT1 by histone demethylase LSD1 promotes cell cycle progression in cancer cells. Cancer Res. 2011 Feb 01; 71(3):655-60.
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RB-E2F1: molecular rheostat for autophagy and apoptosis. Autophagy. 2010 Nov; 6(8):1216-7.